Antiretroviral Therapy Initiation Alters the Redox System of Asymptomatic HIV-Infected Individuals: A Longitudinal Study

• Published in: Oxidative medicine and cellular longevity Vol. 2017; no. 2017; pp. 1 - 10
• Main Authors: Souza, Lenice do Rosário de, Biasin, Mara, Camargo, Caio Cavassan de, Tavares, Francilene Capel, Gatto, Mariana, Correa, C. R., Caleffi, Juliana Trindade, Tasca, Karen Ingrid, Sartori, Alexandrina
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2017; Hindawi; John Wiley & Sons, Inc
• Subjects: Acquired immune deficiency syndrome; Adult; AIDS; alpha-Tocopherol - metabolism; Analysis; Anti-Retroviral Agents - therapeutic use; Antioxidants; Antioxidants - metabolism; Antiviral agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes - cytology; Chromatography, High Pressure Liquid; Diabetes; Dinoprost - analogs & derivatives; Dinoprost - analysis; DNA Damage; Dosage and administration; Drug therapy; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; HIV; HIV Infections - drug therapy; HIV patients; Human immunodeficiency virus; Humans; Longitudinal Studies; Male; Malondialdehyde - analysis; Middle Aged; Oxidation-Reduction; Oxidation-reduction reaction; Oxidative stress; Population; Reverse Transcriptase Inhibitors - therapeutic use; Statistical analysis; Studies; Tropical diseases; Young Adult; Brazil

Background. The combination antiretroviral therapy (cART) increases the oxidative stress in HIV-infected people, which in turn favors the onset and aggravation of non-AIDS comorbidities, a common situation affecting these individuals. We aimed to evaluate the influence of cART initiation on oxidativ...