Impact of Early Versus Late Antiretroviral Treatment Initiation on Naive T Lymphocytes in HIV-1-Infected Children and Adolescents – The-ANRS-EP59-CLEAC Study

• Published in: Frontiers in immunology Vol. 12; p. 662894
• Main Authors: Frange, Pierre, Montange, Thomas, Le Chenadec, Jérôme, Batalie, Damien, Fert, Ingrid, Dollfus, Catherine, Faye, Albert, Blanche, Stéphane, Chacé, Anne, Fourcade, Corine, Hau, Isabelle, Levine, Martine, Mahlaoui, Nizar, Marcou, Valérie, Tabone, Marie-Dominique, Veber, Florence, Hoctin, Alexandre, Wack, Thierry, Avettand-Fenoël, Véronique, Warszawski, Josiane, Buseyne, Florence
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 22.04.2021; Frontiers Media S.A
• Subjects: Adolescent; adolescents; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes - drug effects; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; Child; Child, Preschool; children; early ART; Female; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV-1; HIV-1 - drug effects; Humans; Immunology; Life Sciences; Lymphocyte Activation; Lymphocyte Count; Male; naive T lymphocyte; T lymphocyte; Time-to-Treatment; HIV-1; early ART; naive T lymphocyte; T lymphocyte; adolescents; children

The early initiation of antiretroviral therapy (ART) in HIV-1-infected infants reduces mortality and prevents early CD4 T-cell loss. However, the impact of early ART on the immune system has not been thoroughly investigated in children over five years of age or adolescents. Here, we describe the lev...