Differential Effect of Tacrolimus on Dermal and Intestinal Wound Healing

• Published in: Journal of investigative surgery Vol. 18; no. 2; pp. 71 - 79
• Main Authors: Schäffer, Michael, Fuchs, Nico, Völker, Julia, Schulz, Tim, Kapischke, Matthias, Viebahn, Richard
• Format: Journal Article
• Language: English
• Published: United States Informa UK Ltd 2005; Taylor & Francis
• Subjects: Animals; dermal; Dermis - immunology; Dermis - metabolism; Dermis - surgery; Dose-Response Relationship, Drug; Immunosuppressive Agents - pharmacology; Interferon-gamma - metabolism; intestinal; Intestinal Mucosa - metabolism; Intestines - immunology; Intestines - surgery; Postoperative Complications; rat; Rats; Rats, Sprague-Dawley; Surgical Wound Infection; tacrolimus; Tacrolimus - pharmacology; Transforming Growth Factor beta - metabolism; Tumor Necrosis Factor-alpha - metabolism; wound healing; Wound Healing - drug effects; Wound Healing - immunology

Tacrolimus, used in organ transplantation, inhibits cellular immune function. Little is known about the effect on dermal and colonic healing. Groups of 10 rats underwent dorsal skin incision, and polyvinyl alcohol sponges were implanted subcutaneously. Beginning at the day of wounding, rats were tre...