GBP5 Repression Suppresses the Metastatic Potential and PD-L1 Expression in Triple-Negative Breast Cancer

• Published in: Biomedicines Vol. 9; no. 4; p. 371
• Main Authors: Cheng, Shun-Wen, Chen, Po-Chih, Lin, Min-Hsuan, Ger, Tzong-Rong, Chiu, Hui-Wen, Lin, Yuan-Feng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.04.2021; MDPI
• Subjects: Apoptosis; Biomarkers; Breast cancer; Cell death; Cell migration; Computational neuroscience; Experiments; GBP5; Gene expression; Gene set enrichment analysis; IFN-γ; Kinases; Medical prognosis; Membranes; Metastases; Metastasis; NF-κB; NF-κB protein; PD-L1; PD-L1 protein; Stat1 protein; triple-negative breast cancer; Tumor necrosis factor-α; γ-Interferon; United States > US; Taiwan; PD-L1; GBP5; NF-κB; IFN-γ; triple-negative breast cancer; metastasis

Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype because of its high metastatic potential. Immune evasion due to aberrant expression of programmed cell death ligand 1 (PD-L1) has also been reported recently in metastatic TNBC. However, the mechanism underlying metast...