Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects

• Published in: Frontiers in immunology Vol. 12; p. 676627
• Main Authors: Mazziotta, Chiara, Lanzillotti, Carmen, Torreggiani, Elena, Oton-Gonzalez, Lucia, Iaquinta, Maria Rosa, Mazzoni, Elisa, Gaboriaud, Pauline, Touzé, Antoine, Silvagni, Ettore, Govoni, Marcello, Martini, Fernanda, Tognon, Mauro, Rotondo, John Charles
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 08.06.2021; Frontiers Media S.A
• Subjects: Adult; antibodies; Antibodies, Viral - blood; Antibodies, Viral - immunology; Asymptomatic Infections; Cancer; Capsid Proteins - immunology; Computer Simulation; Data Accuracy; Diagnosis, Computer-Assisted; Enzyme Assays - methods; Enzyme-Linked Immunosorbent Assay - methods; Epitopes - immunology; Female; Healthy Volunteers; Humans; IgGs; Immunoglobulin G - blood; Immunoglobulin G - immunology; Immunology; indirect ELISA; Life Sciences; Male; MCPyV; Merkel cell polyomavirus; Merkel cell polyomavirus - immunology; Microbiology and Parasitology; Middle Aged; Oncogenic Viruses - immunology; Polyomavirus Infections - blood; Polyomavirus Infections - diagnosis; Polyomavirus Infections - virology; Sensitivity and Specificity; Seroepidemiologic Studies; serology; Tumor Virus Infections - blood; Tumor Virus Infections - diagnosis; Tumor Virus Infections - virology; Virology; polyomavirus; indirect ELISA; Merkel cell carcinoma; serology; IgGs; antibodies; MCPyV; Merkel cell polyomavirus

Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays for detecting antibodies (abs) against MCPyV are required....