Effect of the Abnormal Expression of BMP-4 in the Blood of Diabetic Patients on the Osteogenic Differentiation Potential of Alveolar BMSCs and the Rescue Effect of Metformin: A Bioinformatics-Based Study

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 19
• Main Authors: Geng, Wei, Xu, Yifan, Sun, Rongxin, Liang, Chao, Li, Jun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Antidiabetics; Bioinformatics; Biomedical materials; Blood; Bone marrow; Bone morphogenetic protein 4; Bone Morphogenetic Protein 4 - blood; Bone Morphogenetic Protein 4 - genetics; Bone Morphogenetic Protein 4 - metabolism; Bone morphogenetic proteins; Care and treatment; Cbfa-1 protein; Cells, Cultured; Computational Biology - methods; Cytokines; Dental prosthetics; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - metabolism; Diabetics; Differentiation (biology); DNA microarrays; Encyclopedias; Gene expression; Genes; Genomes; Growth factors; Humans; Mathematical analysis; Medical research; Medicine, Experimental; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mesenchyme; Metformin; Metformin - pharmacology; Ontology; Osseointegration; Osteogenesis - drug effects; Osteogenesis - physiology; Patients; Proteins; Signal transduction; Signaling; Smad protein; Software; Stem cells; Surgery; Surgical implants; Transcriptome - drug effects; Transcriptome - physiology; Transplants & implants; Type 2 diabetes; Values; China; United States > US

The success rate of oral implants is lower in type 2 diabetes mellitus (T2DM) patients than in nondiabetic subjects; functional impairment of bone marrow-derived mesenchymal stem cells (BMSCs) is an important underlying cause. Many factors in the blood can act on BMSCs to regulate their biological f...