Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model

• Published in: Viruses Vol. 17; no. 6; p. 762
• Main Authors: Jaeger, Hannah K., Smith, Jessica L., Parkins, Christopher J., Haese, Nicole N., Kreklywich, Craig N., Denton, Michael, Labriola, Caralyn S., Axthelm, Michael K., Barber-Axthelm, Aaron, Chun, Kim, Swanson, Tonya, D’Mello, Rahul J., Morgan, Terry K., Smith, Duncan R., Lo, Jamie O., Hirsch, Alec J., Roberts, Victoria H. J., Streblow, Daniel N.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.05.2025; MDPI
• Subjects: Analysis; Animals; Asian Americans; Autopsies; Birth defects; Brain research; Comparative analysis; Congenital defects; congenital Zika syndrome; Disease Models, Animal; Enzymes; Epidemics; Female; Females; Fetuses; Health aspects; Immune response; immunology; Infections; Laboratory animals; Macaca mulatta; Mutation; Necropsy; non-human primate; Pathogenesis; Pathology; Phylogeny; placenta; Placenta - pathology; Placenta - virology; Pregnancy; Pregnancy Complications, Infectious - pathology; Pregnancy Complications, Infectious - virology; Pregnant women; Prevention; Risk factors; RNA, Viral; Thailand; Ultrasonic imaging; Vasculitis; Veins & arteries; Viremia; Viremia - virology; Zika virus; Zika Virus - classification; Zika Virus - genetics; Zika Virus - isolation & purification; Zika Virus Infection - pathology; Zika Virus Infection - virology; Thailand; United States; United States > US; Southeast Asia; placenta; Zika virus; non-human primate; congenital Zika syndrome; Thailand; immunology

Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to...