Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model

Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to...

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Published inViruses Vol. 17; no. 6; p. 762
Main Authors Jaeger, Hannah K., Smith, Jessica L., Parkins, Christopher J., Haese, Nicole N., Kreklywich, Craig N., Denton, Michael, Labriola, Caralyn S., Axthelm, Michael K., Barber-Axthelm, Aaron, Chun, Kim, Swanson, Tonya, D’Mello, Rahul J., Morgan, Terry K., Smith, Duncan R., Lo, Jamie O., Hirsch, Alec J., Roberts, Victoria H. J., Streblow, Daniel N.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.05.2025
MDPI
Subjects
Analysis
Animals
Asian Americans
Autopsies
Birth defects
Brain research
Comparative analysis
Congenital defects
congenital Zika syndrome
Disease Models, Animal
Enzymes
Epidemics
Female
Females
Fetuses
Health aspects
Immune response
immunology
Infections
Laboratory animals
Macaca mulatta
Mutation
Necropsy
non-human primate
Pathogenesis
Pathology
Phylogeny
placenta
Placenta - pathology
Placenta - virology
Pregnancy
Pregnancy Complications, Infectious - pathology
Pregnancy Complications, Infectious - virology
Pregnant women
Prevention
Risk factors
RNA, Viral
Thailand
Ultrasonic imaging
Vasculitis
Veins & arteries
Viremia
Viremia - virology
Zika virus
Zika Virus - classification
Zika Virus - genetics
Zika Virus - isolation & purification
Zika Virus Infection - pathology
Zika Virus Infection - virology
Thailand
United States
United States > US
Southeast Asia
placenta
Zika virus
non-human primate
congenital Zika syndrome
Thailand
immunology
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Abstract Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
AbstractList Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals ( n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals ( = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have previously shown that infection with the Puerto Rican isolate PRVABC59 (ZIKV-PR) results in abnormal oxygen transport in the placenta due to villous damage and uterine vasculitis in a nonhuman primate model. To investigate whether this type of damage occurs with endemically circulating strains in Thailand, we investigated a CZS case isolate, MU1-2017 (ZIKV-TH), in pregnant rhesus macaques. Pregnant animals (n = 3 per group) were infected subcutaneously with either ZIKV-PR or ZIKV-TH at ~50 days gestation (GD) and monitored for 40 days post-infection (GD90). Similar courses of viremia and immune activation were observed for both viruses when compared to uninfected controls. In addition, both viruses induced changes to the placental architecture, including spiral artery remodeling and the development of infarctions. Similar levels of viral RNA were detected at necropsy in maternal and fetal tissues. Overall, our results show that the ZIKV-TH strain MU1-2017 behaves similarly to the ZIKV-PR strain, and, importantly, provide evidence of in-utero infection with an additional contemporary strain of ZIKV.
Audience Academic
Author Hirsch, Alec J.
Smith, Duncan R.
Denton, Michael
Smith, Jessica L.
Morgan, Terry K.
Haese, Nicole N.
Labriola, Caralyn S.
Chun, Kim
Roberts, Victoria H. J.
Parkins, Christopher J.
Kreklywich, Craig N.
Streblow, Daniel N.
D’Mello, Rahul J.
Swanson, Tonya
Jaeger, Hannah K.
Lo, Jamie O.
Barber-Axthelm, Aaron
Axthelm, Michael K.
AuthorAffiliation 6 Institute of Molecular Biosciences, Mahidol University, Salaya Campus, 25/25 Phuttamonthol Sai 4, Nakhon Pathom 73170, Thailand; duncan_r_smith@hotmail.com
4 Department of Obstetrics & Gynecology, Oregon Health & Science University, Portland, OR 97239, USA
3 Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA robertsv@ohsu.edu (V.H.J.R.)
2 Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
5 Division of Pathology, Oregon Health & Science University, Portland, OR 97239, USA
1 The Vaccine & Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR 97006, USA; jaegerh@ohsu.edu (H.K.J.); hirschal@ohsu.edu (A.J.H.)
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Issue 6
Keywords placenta
Zika virus
non-human primate
congenital Zika syndrome
Thailand
immunology
Language English
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Snippet Zika virus (ZIKV) infection during pregnancy can cause a broad range of neurological birth defects, collectively named Congenital Zika Syndrome (CZS). We have...
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SubjectTerms Analysis
Animals
Asian Americans
Autopsies
Birth defects
Brain research
Comparative analysis
Congenital defects
congenital Zika syndrome
Disease Models, Animal
Enzymes
Epidemics
Female
Females
Fetuses
Health aspects
Immune response
immunology
Infections
Laboratory animals
Macaca mulatta
Mutation
Necropsy
non-human primate
Pathogenesis
Pathology
Phylogeny
placenta
Placenta - pathology
Placenta - virology
Pregnancy
Pregnancy Complications, Infectious - pathology
Pregnancy Complications, Infectious - virology
Pregnant women
Prevention
Risk factors
RNA, Viral
Thailand
Ultrasonic imaging
Vasculitis
Veins & arteries
Viremia
Viremia - virology
Zika virus
Zika Virus - classification
Zika Virus - genetics
Zika Virus - isolation & purification
Zika Virus Infection - pathology
Zika Virus Infection - virology
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Title Comparative Analysis of Two Zika Virus Isolates in a Rhesus Macaque Pregnancy Model
URI https://www.ncbi.nlm.nih.gov/pubmed/40573353
https://www.proquest.com/docview/3223945823
https://www.proquest.com/docview/3224643661
https://pubmed.ncbi.nlm.nih.gov/PMC12197658
https://doaj.org/article/5b20035b5e33499e8da8766a551e07d9
Volume 17
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