Infiltration Profile of Regulatory T Cells in Osteoarthritis-Related Pain and Disability

• Published in: Biomedicines Vol. 10; no. 9; p. 2111
• Main Authors: Nees, Timo Albert, Zhang, Jiji Alexander, Platzer, Hadrian, Walker, Tilman, Reiner, Tobias, Tripel, Elena, Moradi, Babak, Rosshirt, Nils
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.08.2022; MDPI
• Subjects: Arthritis; Arthroplasty (knee); Cartilage; CD25 antigen; CD4 antigen; Cloning; Flow cytometry; Health aspects; Immunoregulation; Infiltration; Inflammation; knee pain; Lymphocytes; Lymphocytes T; Osteoarthritis; Pain; Patients; Peripheral blood; Physiological aspects; regulatory T cells; Surgery; Synovial fluid; Synovial membrane; T cells; Tumor necrosis factor-TNF; Germany; United States > US; regulatory T cells; knee pain; lymphocytes; inflammation; osteoarthritis; synovial fluid; peripheral blood; synovial membrane; T cells

Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disabil...