Infiltration Profile of Regulatory T Cells in Osteoarthritis-Related Pain and Disability
Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disabil...
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| Published in | Biomedicines Vol. 10; no. 9; p. 2111 |
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| Main Authors | , , , , , , , |
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| Language | English |
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| Abstract | Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4
CD25
CD127
) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions-especially in the SM-are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. |
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| AbstractList | Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4+CD25+/high CD127low/−) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions—especially in the SM—are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4[sup.+]CD25[sup.+/high] CD127[sup.low/−]) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions—especially in the SM—are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4 CD25 CD127 ) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions-especially in the SM-are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4+CD25+/high CD127low/-) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions-especially in the SM-are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms.Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4+CD25+/high CD127low/-) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions-especially in the SM-are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. Emerging evidence indicates that regulatory T cells (Treg) intervene in the inflammatory processes that drive osteoarthritis (OA). However, whether polarized Tregs affect clinical features of the disease in the short- or long-term, and if so, what their role in OA-related pain and functional disability really is, remains elusive. Thus, the aim of the current study was to characterize the infiltration profile of Tregs in systemic (peripheral blood) and joint-derived (synovial fluid and synovial membrane) samples from patients with knee OA in relation to OA-induced symptoms. To this end, Treg infiltration (CD4 + CD25 +/high CD127 low/− ) was analyzed in matched samples of peripheral blood (PB), synovial fluid (SF) and synovial membrane (SM) from a total of 47 patients undergoing elective knee arthroplasty using flow cytometry. At the same time, knee pain and function were assessed and correlated with Treg proportions in different compartments (PB, SF, SM). Interestingly, matched-pair analysis revealed significantly higher Treg proportions in joint-derived samples than in PB, which was mainly attributed to the high Treg frequency in SF. Moreover, we found significant associations between infiltrating Tregs and OA-related symptoms which indicate that lower Treg proportions—especially in the SM—are related to increased pain and functional disability in knee OA. In conclusion, this study highlights the importance of local cellular inflammatory processes in OA pathology. Intra-articular Treg infiltration might play an important role not only in OA pathogenesis but also in the development of OA-related symptoms. |
| Audience | Academic |
| Author | Walker, Tilman Reiner, Tobias Tripel, Elena Zhang, Jiji Alexander Rosshirt, Nils Nees, Timo Albert Moradi, Babak Platzer, Hadrian |
| AuthorAffiliation | 2 Clinic for Orthopedics and Trauma Surgery, University Hospital Kiel, 24105 Kiel, Germany 1 Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany |
| AuthorAffiliation_xml | – name: 2 Clinic for Orthopedics and Trauma Surgery, University Hospital Kiel, 24105 Kiel, Germany – name: 1 Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany |
| Author_xml | – sequence: 1 givenname: Timo Albert orcidid: 0000-0003-4292-604X surname: Nees fullname: Nees, Timo Albert organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 2 givenname: Jiji Alexander orcidid: 0000-0002-4430-7413 surname: Zhang fullname: Zhang, Jiji Alexander organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 3 givenname: Hadrian orcidid: 0000-0001-9805-3810 surname: Platzer fullname: Platzer, Hadrian organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 4 givenname: Tilman surname: Walker fullname: Walker, Tilman organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 5 givenname: Tobias surname: Reiner fullname: Reiner, Tobias organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 6 givenname: Elena surname: Tripel fullname: Tripel, Elena organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany – sequence: 7 givenname: Babak surname: Moradi fullname: Moradi, Babak organization: Clinic for Orthopedics and Trauma Surgery, University Hospital Kiel, 24105 Kiel, Germany – sequence: 8 givenname: Nils orcidid: 0000-0002-8672-1938 surname: Rosshirt fullname: Rosshirt, Nils organization: Department of Orthopedics, Heidelberg University Hospital, 69118 Heidelberg, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36140212$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_molimm_2023_10_002 crossref_primary_10_1016_S2665_9913_23_00190_X crossref_primary_10_3389_fimmu_2023_1247710 crossref_primary_10_1136_ard_2023_224907 crossref_primary_10_1016_j_joca_2024_06_011 crossref_primary_10_1186_s12891_022_06098_8 crossref_primary_10_1002_adma_202311646 |
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| Keywords | regulatory T cells knee pain lymphocytes inflammation osteoarthritis synovial fluid peripheral blood synovial membrane T cells |
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| SubjectTerms | Arthritis Arthroplasty (knee) Cartilage CD25 antigen CD4 antigen Cloning Flow cytometry Health aspects Immunoregulation Infiltration Inflammation knee pain Lymphocytes Lymphocytes T Osteoarthritis Pain Patients Peripheral blood Physiological aspects regulatory T cells Surgery Synovial fluid Synovial membrane T cells Tumor necrosis factor-TNF |
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| Title | Infiltration Profile of Regulatory T Cells in Osteoarthritis-Related Pain and Disability |
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