Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

• Published in: Cell Vol. 183; no. 1; pp. 76 - 93.e22
• Main Authors: Zhao, Qiyi, Liu, Jiayu, Deng, Hong, Ma, Ruiying, Liao, Jian-You, Liang, Huixin, Hu, Jingxiong, Li, Jiaqian, Guo, Zhiyong, Cai, Junchao, Xu, Xiaoding, Gao, Zhiliang, Su, Shicheng
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2020
• Subjects: circular RNA; endoplasmic reticulum; fatty liver; fibroblasts; genome; insulin resistance; lipids; liver; mitochondria; therapeutics

Mitochondria, which play central roles in immunometabolic diseases, have their own genome. However, the functions of mitochondria-located noncoding RNAs are largely unknown due to the absence of a specific delivery system. By circular RNA (circRNA) expression profile analysis of liver fibroblasts fr...