Case Report: Acquired Disseminated BCG in the Context of a Delayed Immune Reconstitution After Hematological Malignancy

• Published in: Frontiers in immunology Vol. 12; p. 696268
• Main Authors: Gies, Vincent, Dieudonné, Yannick, Morel, Florence, Sougakoff, Wladimir, Carapito, Raphaël, Martin, Aurélie, Weingertner, Noëlle, Jacquel, Léa, Hubele, Fabrice, Kuhnert, Cornelia, Jung, Sophie, Schramm, Frederic, Boyer, Pierre, Hansmann, Yves, Danion, François, Korganow, Anne-Sophie, Guffroy, Aurélien
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 03.08.2021; Frontiers Media S.A
• Subjects: Administration, Intravesical; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Antitubercular Agents - therapeutic use; BCG; BCG Vaccine - administration & dosage; BCG Vaccine - adverse effects; BCGosis-susceptible PIDs; case report; contamination; Hematologic Neoplasms - drug therapy; hematological malignancies; Host-Pathogen Interactions; Human health and pathology; Humans; Immune Reconstitution; Immunocompromised Host; Immunodeficiency; Immunology; Life Sciences; Male; Middle Aged; Mycobacterium bovis - drug effects; Mycobacterium bovis - immunology; Mycobacterium bovis - pathogenicity; Opportunistic Infections - drug therapy; Opportunistic Infections - immunology; Opportunistic Infections - microbiology; Risk Factors; Treatment Outcome; Tuberculosis, Pulmonary - diagnosis; Tuberculosis, Pulmonary - drug therapy; Tuberculosis, Pulmonary - immunology; Tuberculosis, Pulmonary - microbiology; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - immunology; hematological malignancies; case report; BCGosis-susceptible PIDs; BCG; Immunodeficiency; contamination

Disseminated infections due to Bacillus Calmette-Guérin (BCG) are unusual and occur mostly in patients with inborn error of immunity (IEI) or acquired immunodeficiency. However, cases of secondary BCGosis due to intravesical BCG instillation have been described. Herein, we present a case of severe B...