Susceptibility to Astrocytoma in Mice Mutant for Nf1 and Trp53 Is Linked to Chromosome 11 and Subject to Epigenetic Effects

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 101; no. 35; pp. 13008 - 13013
• Main Authors: Reilly, Karlyne M., Tuskan, Robert G., Christy, Emily, Loisel, Dagan A., Ledger, Jeremy, Bronson, Roderick T., Smith, C. Dahlem, Tsang, Shirley, Munroe, David J., Jacks, Tyler, Vogelstein, Bert
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 31.08.2004; National Acad Sciences
• Subjects: Alleles; Animals; Apoptosis Regulatory Proteins; Astrocytoma; Astrocytoma - genetics; Astrocytoma - pathology; Biological Sciences; Carrier Proteins - genetics; Crosses, Genetic; Cytoplasmic inheritance; Female; Genetic inheritance; Genetic Linkage; Genetic mutation; Genetic Predisposition to Disease; Heat-Shock Proteins - genetics; Inbred strains; Inbreeding; Male; Medical genetics; Mice; Models, Genetic; Neurofibromin 1 - genetics; Tumors

Astrocytoma is the most common malignant brain tumor in humans. Loss of the p53 signaling pathway and up-regulation of the ras signaling pathway are common during tumor progression. We have shown previously that mice mutant for Trp53 and Nf1 develop astrocytoma, progressing to glioblastoma, on a C57...