Defensins and Sepsis

Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicid...

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Published inBioMed research international Vol. 2014; no. 2014; pp. 1 - 5
Main Authors Fang, Xiang-Ming, Cheng, Bao-Li, Chen, Qi-Xing, Xie, Guo-Hao
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Puplishing Corporation 01.01.2014
Hindawi Publishing Corporation
Hindawi Limited
Subjects
Adaptive Immunity
Adenoviruses
Antimicrobial agents
Bacteria
Biomedical research
Defensins - genetics
Defensins - immunology
Defensins - metabolism
Dendritic Cells - immunology
Dendritic Cells - metabolism
Dendritic Cells - pathology
E coli
Genes
Gram-negative bacteria
Humans
Immune system
Immunity, Innate
Infections
Interleukin-1beta - immunology
Interleukin-1beta - metabolism
Mortality
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - pathology
Peptides
Phagocytosis - immunology
Review
Sepsis
Sepsis - drug therapy
Sepsis - immunology
Sepsis - pathology
Studies
T-Lymphocytes - immunology
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Abstract Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity against various infections. Defensins can recruit neutrophils, enhance phagocytosis, chemoattract T cells and dendritic cells, promote complement activation, and induce IL-1β production and pyrotosis. Previous publications have documented that defensins play important roles in a series of immune inflammatory diseases including sepsis. This review aims to briefly summarize in vitro, in vivo, and genetic studies on defensins’ effects as well as corresponding mechanisms within sepsis and highlights their promising findings which may be potential targets in future therapies of sepsis.
AbstractList Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity against various infections. Defensins can recruit neutrophils, enhance phagocytosis, chemoattract T cells and dendritic cells, promote complement activation, and induce IL-1β production and pyrotosis. Previous publications have documented that defensins play important roles in a series of immune inflammatory diseases including sepsis. This review aims to briefly summarize in vitro, in vivo, and genetic studies on defensins’ effects as well as corresponding mechanisms within sepsis and highlights their promising findings which may be potential targets in future therapies of sepsis.
Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity against various infections. Defensins can recruit neutrophils, enhance phagocytosis, chemoattract T cells and dendritic cells, promote complement activation, and induce IL-1 β production and pyrotosis. Previous publications have documented that defensins play important roles in a series of immune inflammatory diseases including sepsis. This review aims to briefly summarize in vitro, in vivo, and genetic studies on defensins' effects as well as corresponding mechanisms within sepsis and highlights their promising findings which may be potential targets in future therapies of sepsis.
Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis. Defensins are endogenous antimicrobial peptides with three disulphide bonds created by six cysteine residues. Besides the intrinsic microbicidal properties, defensins are active players which modulate both innate and adaptive immunity against various infections. Defensins can recruit neutrophils, enhance phagocytosis, chemoattract T cells and dendritic cells, promote complement activation, and induce IL-1 beta production and pyrotosis. Previous publications have documented that defensins play important roles in a series of immune inflammatory diseases including sepsis. This review aims to briefly summarize in vitro, in vivo, and genetic studies on defensins' effects as well as corresponding mechanisms within sepsis and highlights their promising findings which may be potential targets in future therapies of sepsis.
Author Xie, Guo-Hao
Fang, Xiang-Ming
Cheng, Bao-Li
Chen, Qi-Xing
AuthorAffiliation Department of Anesthesiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou 31003, China
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Fang, Xiang-Ming
Cheng, Bao-Li
Chen, Qi-Xing
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Copyright Copyright © 2014 Guo-Hao Xie et al.
Copyright © 2014 Guo-Hao Xie et al. Guo-Hao Xie et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright © 2014 Guo-Hao Xie et al. 2014
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Snippet Sepsis is a leading cause of mortality and morbidity in the critical illness. Multiple immune inflammatory processes take part in the pathogenesis of sepsis....
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SubjectTerms Adaptive Immunity
Adenoviruses
Antimicrobial agents
Bacteria
Biomedical research
Defensins - genetics
Defensins - immunology
Defensins - metabolism
Dendritic Cells - immunology
Dendritic Cells - metabolism
Dendritic Cells - pathology
E coli
Genes
Gram-negative bacteria
Humans
Immune system
Immunity, Innate
Infections
Interleukin-1beta - immunology
Interleukin-1beta - metabolism
Mortality
Neutrophils - immunology
Neutrophils - metabolism
Neutrophils - pathology
Peptides
Phagocytosis - immunology
Review
Sepsis
Sepsis - drug therapy
Sepsis - immunology
Sepsis - pathology
Studies
T-Lymphocytes - immunology
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Title Defensins and Sepsis
URI https://search.emarefa.net/detail/BIM-452284
https://dx.doi.org/10.1155/2014/180109
https://www.ncbi.nlm.nih.gov/pubmed/25210703
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https://pubmed.ncbi.nlm.nih.gov/PMC4151856
Volume 2014
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