Sleep propensity at daytime as assessed by Multiple Sleep Latency Tests (MSLT) in patients with schizophrenia increases with clozapine and olanzapine

• Published in: Schizophrenia research Vol. 135; no. 1-3; pp. 123 - 127
• Main Authors: Kluge, Michael, Himmerich, Hubertus, Wehmeier, Peter M., Rummel-Kluge, Christine, Dalal, Mira, Hinze-Selch, Dunja, Kraus, Thomas, Dittmann, Ralf W., Pollmächer, Thomas, Schuld, Andreas
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.2012; Elsevier
• Subjects: Adolescent; Adult; Adult and adolescent clinical studies; Aged; Analysis of Variance; Antipsychotic Agents - therapeutic use; Atypical antipsychotics; Benzodiazepines - therapeutic use; Biological and medical sciences; Clozapine - therapeutic use; Disorders of Excessive Somnolence - drug therapy; Disorders of Excessive Somnolence - etiology; Double-Blind Method; Female; Humans; Male; Medical sciences; Middle Aged; Neuropharmacology; Pharmacology. Drug treatments; Polysomnography; Psychiatric Status Rating Scales; Psychiatry; Psycholeptics: tranquillizer, neuroleptic; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Psychoses; Reaction Time - drug effects; Schizophrenia; Schizophrenia - complications; Schizophrenia - drug therapy; Sedation; Sleep Stages - drug effects; Sleepiness; Statistics as Topic; Time Factors; Young Adult; Schizophrenia; Atypical antipsychotics; Sedation; Sleepiness; Human; Dibenzodiazepine derivatives; Atypical antipsychotic; Olanzapine; Neuroleptic; Psychotropic; Dopamine antagonist; Serotonin antagonist; Asleeping; Serotonine receptor; Clozapine; Waiting time; Thienobenzodiazepine derivatives; Psychosis; Somnolence; D2 Dopamine receptor; Sleep; Sleep wake cycle

Sleep propensity at daytime has not been investigated in untreated patients with schizophrenia. Furthermore, while the antipsychotics clozapine and olanzapine are considered to frequently cause ‘sleepiness’ or ‘sedation’, this has not been objectified yet. Therefore, 30 patients with schizophrenia w...