Novel Viral Sequences in a Patient with Cryptogenic Liver Cirrhosis Revealed by Serum Virome Sequencing

• Published in: Viruses Vol. 17; no. 6; p. 812
• Main Authors: Zhang, Xiaoan, Fan, Ida X., Xu, Yanjuan, Rule, Jody, Tse, Long Ping Victor, Pourkarim, Mahmoud Reza, Lee, William M., Di Bisceglie, Adrian M., Fan, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.06.2025; MDPI
• Subjects: Adult; Aged; Analysis; Blood & organ donations; Blood donors; Cirrhosis; Contaminants; Copy number; cryptogenic cirrhosis; cryptogenic liver disease; DNA polymerase; DNA sequencing; Enzymes; Etiology; Female; Gene mapping; Genetic aspects; Genetic testing; Genome, Viral; Genomes; Health aspects; Hepatitis; Hepatitis A; hepatitis virus; Humans; Hypothesis testing; Infections; Liver cirrhosis; Liver Cirrhosis - virology; Liver diseases; Liver transplants; Male; Metagenomics; Middle Aged; Nucleotide sequencing; Patients; Polymerase chain reaction; Prevention; Reverse transcription; Risk factors; Sequence Analysis, DNA; Serum - virology; Single-stranded DNA; Testing; Testing laboratories; virome; Virome - genetics; Viruses; Viruses - classification; Viruses - genetics; Viruses - isolation & purification; China; United Kingdom > UK; England; United States > US; virome; cryptogenic cirrhosis; hepatitis virus; cryptogenic liver disease; etiology

Clinical studies indicate the etiology of liver disease to be unknown in 5% to 30% of patients. A long-standing hypothesis is the existence of unknown viruses beyond hepatitis A through E virus. We conducted serum virome sequencing in nine patients with cryptogenic liver disease and identified eight...