Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases

• Published in: Biomedicines Vol. 9; no. 4; p. 396
• Main Authors: Vaneev, Alexander N., Kost, Olga A., Eremeev, Nikolay L., Beznos, Olga V., Alova, Anna V., Gorelkin, Peter V., Erofeev, Alexander S., Chesnokova, Natalia B., Kabanov, Alexander V., Klyachko, Natalia L.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 07.04.2021; MDPI
• Subjects: Acids; Allergenicity; Antioxidants; Blindness; Cornea; Degeneration; double-layered polyelectrolyte complex; Edema; Enzymatic activity; Enzymes; Eye diseases; Fibrin; Hyperemia; Immunogenicity; Inflammation; Inflammatory diseases; Irritation; Ischemia; Molecular weight; Mutagenicity; Nano-SOD1; Nanoparticles; Oxidative stress; Proteins; Reactive oxygen species; Shelf life; Side reactions; Statistical analysis; Superoxide dismutase; Toxicity; Uveitis; United States > US; eye diseases; nanoparticles; inflammation; Nano-SOD1; drug delivery; uveitis; double-layered polyelectrolyte complex

Inflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurri...