Leukocyte-derived MMP9 is crucial for the recruitment of proinflammatory macrophages in experimental glomerulonephritis

• Published in: Kidney international Vol. 83; no. 5; pp. 865 - 877
• Main Authors: Kluger, Malte A, Zahner, Gunther, Paust, Hans-Joachim, Schaper, Melanie, Magnus, Tim, Panzer, Ulf, Stahl, Rolf A K
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2013; Elsevier Limited
• Subjects: Animals; Bone Marrow Transplantation; Cells, Cultured; Chemokines - metabolism; Chemotaxis; cytokines; Disease Models, Animal; Disease Progression; extracellular matrix; glomerular disease; Glomerulonephritis - enzymology; Glomerulonephritis - immunology; Glomerulonephritis - pathology; Glomerulonephritis - prevention & control; immunology and pathology; inflammation; Inflammation Mediators - metabolism; Leukocytes - enzymology; Leukocytes - immunology; Macrophages, Peritoneal - enzymology; Macrophages, Peritoneal - immunology; Male; Matrix Metalloproteinase 9 - deficiency; Matrix Metalloproteinase 9 - genetics; Matrix Metalloproteinase 9 - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephrons - enzymology; Nephrons - immunology; Nephrons - pathology; Phenotype; Time Factors; immunology and pathology; cytokines; glomerular disease; inflammation; extracellular matrix

Matrix metalloproteinase 9 (MMP9) is a conditionally expressed enzyme and is upregulated in glomerulonephritis. Its function in these diseases, however, remains to be fully elucidated. The induction of nephrotoxic serum nephritis (NTN) in wild-type mice resulted in an upregulation of MMP9, followed...