Expression of SASH1 in Preeclampsia and Its Effects on Human Trophoblast

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 8
• Main Authors: Yu, Yanhong, Huang, Liping, Jiang, Sijia, Liu, Shisan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Adapter proteins; Adult; Antibodies; Apoptosis; Apoptosis - genetics; Assaying; Biopsy; Biotechnology; Cancer; Cell adhesion & migration; Cell Line; Cell migration; Cell Movement - genetics; Cell proliferation; Cell Proliferation - genetics; Cholecystokinin; Development and progression; Female; Flow cytometry; Gene expression; Genetic aspects; Gestational age; Health aspects; Humans; Hypertension; Immunohistochemistry; Obstetrical research; Placenta; Placenta - metabolism; Pre-eclampsia; Pre-Eclampsia - genetics; Pre-Eclampsia - metabolism; Preeclampsia; Pregnancy; Risk factors; Software; Statistical analysis; Transfection; Trophoblast; Trophoblasts - metabolism; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Up-Regulation - genetics; Womens health; China; United States > US; Japan

Aim. To explore the involvement of SASH1 in preeclampsia. Methods. Expression of SASH1 was determined by qPCR, WB, and immunohistochemistry in the placenta of both normal and preeclamptic pregnancies. The SASH1 gene of human HTR-8/SVneo cells was overexpressed by transfection of pEZ-Lv206-SASH1. Aft...