The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery

Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We d...

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Published inNatural product reports Vol. 36; no. 5; pp. 698 - 713
Main Authors Jamieson, Cooper S, Ohashi, Masao, Liu, Fang, Tang, Yi, Houk, K. N
Format Journal Article
LanguageEnglish
Published England 22.05.2019
Subjects
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
biosynthesis
Catalysis
catalytic activity
chemical reactions
Cyclization
enzymes
Enzymes - chemistry
Enzymes - metabolism
Naphthalenes - chemistry
Naphthalenes - metabolism
Protein Conformation
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Abstract Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review. The pericyclases are Nature's route to spirotetronates, statins, myceliothermophins, leporins and more.
AbstractList Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the “pericyclases,” are the subject of this review.
Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in Nature that catalyze pericyclic reactions. These enzymes, the “pericyclases,” are the subject of this review.
Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review.Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review.
Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the “pericyclases,” are the subject of this review.
Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review, enzyme-catalyzed pericyclic reactions were not widely known to be involved in biosynthesis. This situation is changing rapidly. We define the scope of pericyclic reactions, give a historical account of their discoveries as biosynthetic reactions, and provide evidence that there are many enzymes in nature that catalyze pericyclic reactions. These enzymes, the "pericyclases," are the subject of this review. The pericyclases are Nature's route to spirotetronates, statins, myceliothermophins, leporins and more.
Author Houk, K. N
Ohashi, Masao
Liu, Fang
Tang, Yi
Jamieson, Cooper S
AuthorAffiliation Department of Chemistry and Biochemistry
Department of Chemical and Biomolecular Engineering
University of California
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  givenname: Cooper S
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  fullname: Houk, K. N
BackLink https://www.ncbi.nlm.nih.gov/pubmed/30311924$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1021/bi00742a022
10.1016/j.cbpa.2016.01.020
10.1021/jacs.6b00232
10.1039/b911516c
10.1021/jacs.6b00017
10.1021/jacs.5b00940
10.1039/B305068H
10.1038/nature09981
10.1016/j.fgb.2015.05.010
10.1021/ja00011a048
10.1021/jo952053i
10.1021/acs.orglett.5b02149
10.1002/asia.201700442
10.1073/pnas.1401073111
10.1021/ja9615278
10.1039/b901177n
10.1021/cr300436a
10.1021/ja9005332
10.1002/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO;2-Z
10.1016/S0969-2126(01)00618-9
10.1039/c2ob25827g
10.1038/ja.2016.67
10.1002/cbic.201500386
10.1021/ol302265z
10.1021/bi2009739
10.1038/nature01454
10.1002/chem.200700038
10.1021/ja00312a058
10.1021/jacs.7b05060
10.1039/C5OB01771H
10.1002/anie.196905561
10.1038/nbt.2109
10.1021/acs.accounts.6b00375
10.1021/acs.joc.5b01951
10.1038/nchem.1843
10.1021/jacs.8b01681
10.1073/pnas.1719368115
10.1016/S0167-4838(98)00040-5
10.1016/j.bbrc.2015.03.011
10.1002/cbic.201402373
10.1021/cr00061a001
10.1074/jbc.M003119200
10.1039/c0ob00167h
10.1021/ar50001a003
10.1021/ja055871t
10.1126/science.1190239
10.1038/nchembio.1769
10.1073/pnas.1209316109
10.1021/jacs.5b10136
10.1055/s-0036-1590870
10.1021/acs.chemrev.6b00578
10.1021/ja9643331
10.1021/ja2034969
10.1021/ja003216+
10.1002/anie.201302406
10.1515/pac-2017-0104
10.1021/acs.biochem.7b01161
10.1021/jacs.7b13562
10.1021/ja510711x
10.1021/jo011180d
10.1021/cr00013a014
10.1038/nature14560
10.1021/jacs.6b10452
10.1002/anie.200200534
10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L
10.1021/cen-v083n019.p038
10.1021/ja016622h
10.1126/science.8211138
10.1038/nchembio.1385
10.1055/s-2003-39171
10.1021/ja043905b
10.1002/anie.196907811
10.1002/anie.200800918
10.1002/anie.201703932
10.1021/ja00263a059
10.1021/ja01592a102
10.1002/anie.201711482
10.1039/C4NP00031E
10.1021/acs.orglett.7b02434
10.1038/nature23882
10.1038/nchembio.2327
10.1021/ja01590a079
10.1021/ja01859a055
10.1016/0040-4020(58)88022-9
10.1038/nchem.1694
10.1021/cr0503097
10.1039/C39950001321
10.1021/ja409928z
10.1002/1439-7633(20001117)1:4<255::AID-CBIC255>3.0.CO;2-S
10.1021/cr60298a001
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Notes Masao Ohashi was born in 1986 in Ibaraki, Japan. He received his Ph.D. in 2015 in Medicinal Chemistry from Okayama University, Japan. From 2015 to 2016, he joined the Department of Pharmaceutical Sciences at the University of Shizuoka as a designated assistant professor. In 2016, he joined Prof. Yi Tang's lab at the University of California, Los Angeles, as a postdoctoral scholar. His current research interests focus on the identification of new enzymes that catalyze unusual reactions, such as pericyclic reactions, in nature.
Kendall N. Houk received his PhD at Harvard with R. B. Woodward in 1968, for experimental work on pericyclic reactions. He was at Louisiana State University, the University of Pittsburgh, and the National Science Foundation before joining the University of California Los Angeles (UCLA) where he is the Saul Winstein Chair in Organic Chemistry. He is a Fellow of the American Academy of Arts and Sciences and a Member of the US National Academy of Sciences and the International Academy of Quantum Molecular Sciences.
Yi Tang received his undergraduate degree in Chemical Engineering and Material Science from Penn State University. He received his Ph.D. in Chemical Engineering from California Institute of Technology in 2002. After NIH postdoctoral training in Chemical Biology at Stanford University, he started his independent career at the University of California Los Angeles in 2004. He is currently the Chancellor Professor in the Department of Chemical and Biomolecular Engineering at UCLA, and holds joint appointments in the Department of Chemistry and Biochemistry; and Department of Bioengineering. His lab is interested in natural product biosynthesis, biocatalysis and protein engineering.
Cooper S. Jamieson was born in New York, New York and raised in San Luis Obispo, CA. In 2016, he received a B.A. in Chemistry and a B.A. in Art from Lewis & Clark College in Portland, OR. Cooper worked in art conservation at the Chinati Foundation in far-West Marfa, Texas before beginning a PhD under the direction of K. N. Houk and Y. Tang at UCLA.
Fang Liu received her B.S. in Chemistry from Nankai University, China, in 2009 and her Ph.D. with K. N. Houk at UCLA in 2014, from studying gating in container molecules and the factors controlling reactivity in bioorthogonal cycloadditions. She continued as a postdoctoral fellow in the Houk group at UCLA and the Liang group at Nanjing University. She is a Professor at Nanjing Agricultural University and principal designer/artist of DesignOne, a scientific design studio.
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References Misale (C8NP00075A-(cit15)/*[position()=2]) 2016; 49
Preiswerk (C8NP00075A-(cit21)/*[position()=1]) 2014; 111
Zhu (C8NP00075A-(cit72)/*[position()=1]) 2017; 56
Woodward (C8NP00075A-(cit8)/*[position()=2]) 1956; 78
Kim (C8NP00075A-(cit31)/*[position()=1]) 2011; 473
Lamb (C8NP00075A-(cit43)/*[position()=1]) 2011; 50
Ose (C8NP00075A-(cit28a)/*[position()=1]) 2003; 422
Watanabe (C8NP00075A-(cit27)/*[position()=1]) 2000; 49
Kato (C8NP00075A-(cit53)/*[position()=1]) 2015; 460
Ohashi (C8NP00075A-(cit66)/*[position()=1]) 2017; 549
Jeon (C8NP00075A-(cit37)/*[position()=1]) 2017; 117
Siegel (C8NP00075A-(cit16)/*[position()=1]) 2010; 329
Woodward (C8NP00075A-(cit8)/*[position()=3]) 1958; 2
Ilardi (C8NP00075A-(cit82)/*[position()=1]) 2009; 38
Ilardi (C8NP00075A-(cit68)/*[position()=1]) 2009; 38
Oikawa (C8NP00075A-(cit22a)/*[position()=1]) 2004; 21
Li (C8NP00075A-(cit54)/*[position()=1]) 2016; 138
Luk (C8NP00075A-(cit45)/*[position()=1]) 2011; 133
Eiben (C8NP00075A-(cit20)/*[position()=1]) 2012; 30
Diedrich (C8NP00075A-(cit50)/*[position()=1]) 1997; 119
Nicolaou (C8NP00075A-(cit75)/*[position()=1]) 2000; 39
Li (C8NP00075A-(cit69)/*[position()=1]) 2015; 137
Ferguson (C8NP00075A-(cit46c)/*[position()=1]) 2017; 139
Shipman (C8NP00075A-(cit44)/*[position()=1]) 2001; 9
Xu (C8NP00075A-(cit26)/*[position()=1]) 2013; 52
Ilardi (C8NP00075A-(cit11)/*[position()=1]) 2009; 38
Li (C8NP00075A-(cit70)/*[position()=1]) 2017; 13
Houk (C8NP00075A-(cit3)/*[position()=1]) 1986; 108
Auclair (C8NP00075A-(cit23)/*[position()=1]) 2000; 122
Oikawa (C8NP00075A-(cit63)/*[position()=1]) 2004; 21
Healy (C8NP00075A-(cit51)/*[position()=1]) 2015; 13
Nubbemeyer (C8NP00075A-(cit81)/*[position()=1]) 2003; 2003
Mikami (C8NP00075A-(cit80)/*[position()=1]) 1992; 92
Sato (C8NP00075A-(cit52)/*[position()=1]) 2015; 16
Cope (C8NP00075A-(cit67)/*[position()=1]) 1940; 62
Hoffmann (C8NP00075A-(cit78)/*[position()=1]) 1969; 8
Hare (C8NP00075A-(cit47b)/*[position()=1]) 2017; 89
Zheng (C8NP00075A-(cit39)/*[position()=1]) 2016; 31
Yang (C8NP00075A-(cit86)/*[position()=1]) 2018; 140
Getty (C8NP00075A-(cit5)/*[position()=1]) 1991; 113
Chen (C8NP00075A-(cit13b)/*[position()=1]) 2018; 57
Byrne (C8NP00075A-(cit34)/*[position()=1]) 2016; 138
Katayama (C8NP00075A-(cit25)/*[position()=1]) 1998; 1384
Wever (C8NP00075A-(cit35)/*[position()=1]) 2015; 137
Woodward (C8NP00075A-(cit1)/*[position()=3]) 1970
Ose (C8NP00075A-(cit28b)/*[position()=1]) 2004; D60
Tian (C8NP00075A-(cit32)/*[position()=1]) 2015; 11
Stocking (C8NP00075A-(cit62)/*[position()=1]) 2003; 42
Beno (C8NP00075A-(cit4)/*[position()=1]) 1996; 118
Gouverneur (C8NP00075A-(cit17)/*[position()=1]) 1993; 262
Hashimoto (C8NP00075A-(cit33)/*[position()=1]) 2015; 137
Desimoni (C8NP00075A-(cit60)/*[position()=1]) 1975; 75
Oikawa (C8NP00075A-(cit24)/*[position()=1]) 1995
Yang (C8NP00075A-(cit55)/*[position()=1]) 2007; 13
Hoffmann (C8NP00075A-(cit1a)/*[position()=1]) 1968; 1
DeClue (C8NP00075A-(cit42)/*[position()=1]) 2005; 127
Hess (C8NP00075A-(cit56)/*[position()=1]) 2012; 10
Jiang (C8NP00075A-(cit76)/*[position()=1]) 2013; 113
Kim (C8NP00075A-(cit19)/*[position()=1]) 2002; 67
Newmister (C8NP00075A-(cit71)/*[position()=1]) 2017
Zhang (C8NP00075A-(cit14)/*[position()=1]) 2018; 140
Ess (C8NP00075A-(cit47a)/*[position()=1]) 2008; 47
Hong (C8NP00075A-(cit41c)/*[position()=1]) 2014; 6
Li (C8NP00075A-(cit48)/*[position()=1]) 2014; 31
Hong (C8NP00075A-(cit41b)/*[position()=1]) 2010; 8
Klas (C8NP00075A-(cit38)/*[position()=1]) 2015; 80
Barcan (C8NP00075A-(cit12)/*[position()=1]) 2012; 14
Andrews (C8NP00075A-(cit40)/*[position()=1]) 1973; 12
Nicolaou (C8NP00075A-(cit9)/*[position()=3]) 2002; 41
Nicolaou (C8NP00075A-(cit74)/*[position()=1]) 2002; 41
Souris (C8NP00075A-(cit15)/*[position()=1]) 2015; 17
Hong (C8NP00075A-(cit41a)/*[position()=1]) 2009; 131
Cary (C8NP00075A-(cit61)/*[position()=1]) 2015; 81
Stork (C8NP00075A-(cit10)/*[position()=1]) 2017; 19
Wilson (C8NP00075A-(cit30)/*[position()=1]) 2005; 83
Lutz (C8NP00075A-(cit73)/*[position()=1]) 1984; 84
Krenske (C8NP00075A-(cit46a)/*[position()=1]) 2013; 135
Woodward (C8NP00075A-(cit8)/*[position()=1]) 1956; 78
Minami (C8NP00075A-(cit36)/*[position()=1]) 2016; 69
Chen (C8NP00075A-(cit18)/*[position()=1]) 2000; 1
Payne (C8NP00075A-(cit46b)/*[position()=1]) 2017; 522
Caramella (C8NP00075A-(cit59)/*[position()=1]) 2002; 124
Patel (C8NP00075A-(cit57)/*[position()=1]) 2016; 138
Jessen (C8NP00075A-(cit64)/*[position()=1]) 2010; 27
Nicolaou (C8NP00075A-(cit9)/*[position()=1]) 1996
Snider (C8NP00075A-(cit79)/*[position()=1]) 1985; 107
Rosenthal (C8NP00075A-(cit84)/*[position()=1]) 2014; 10
(C8NP00075A-(cit22b)/*[position()=1]) 2010
Black (C8NP00075A-(cit7)/*[position()=1]) 2012; 109
Baldwin (C8NP00075A-(cit6)/*[position()=1]) 1970
Katsuyama (C8NP00075A-(cit85)/*[position()=1]) 2014; 15
Bian (C8NP00075A-(cit83)/*[position()=1]) 2017; 28
Walsh (C8NP00075A-(cit87)/*[position()=1]) 2018; 57
Snider (C8NP00075A-(cit65)/*[position()=1]) 1996; 61
Png (C8NP00075A-(cit77)/*[position()=1]) 2017; 12
Fischbach (C8NP00075A-(cit49)/*[position()=1]) 2006; 106
Lu (C8NP00075A-(cit13a)/*[position()=1]) 2013; 5
Woodward (C8NP00075A-(cit1b)/*[position()=1]) 1969; 8
Guimarães (C8NP00075A-(cit29)/*[position()=1]) 2005; 127
Yang (C8NP00075A-(cit58)/*[position()=1]) 2018; 115
References_xml – issn: 1970
  publication-title: The Conservation of Orbital Symmetry
  doi: Woodward Hoffmann
– issn: 1970
  end-page: p 281-310
  publication-title: Dynamic Stereochemistry
  doi: Baldwin Fleming
– issn: 1996
  publication-title: Classics in Total Synthesis: Targets, Strategies, Mechanisms
  doi: Nicolaou Sorensen
– issn: 2010
  publication-title: Comprehensive Natural Products II
– volume: 12
  start-page: 3492
  year: 1973
  ident: C8NP00075A-(cit40)/*[position()=1]
  publication-title: Biochemistry
  doi: 10.1021/bi00742a022
– volume: 31
  start-page: 95
  year: 2016
  ident: C8NP00075A-(cit39)/*[position()=1]
  publication-title: Curr. Opin. Chem. Biol.
  doi: 10.1016/j.cbpa.2016.01.020
– volume: 138
  start-page: 6095
  year: 2016
  ident: C8NP00075A-(cit34)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b00232
– volume: 27
  start-page: 1168
  year: 2010
  ident: C8NP00075A-(cit64)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/b911516c
– volume: 138
  start-page: 3631
  year: 2016
  ident: C8NP00075A-(cit57)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b00017
– volume: 137
  start-page: 3494
  year: 2015
  ident: C8NP00075A-(cit35)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.5b00940
– volume: 21
  start-page: 321
  year: 2004
  ident: C8NP00075A-(cit63)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/B305068H
– volume: 473
  start-page: 109
  year: 2011
  ident: C8NP00075A-(cit31)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/nature09981
– volume: 81
  start-page: 88
  year: 2015
  ident: C8NP00075A-(cit61)/*[position()=1]
  publication-title: Fungal Genet. Biol.
  doi: 10.1016/j.fgb.2015.05.010
– volume: 113
  start-page: 4334
  year: 1991
  ident: C8NP00075A-(cit5)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00011a048
– volume: 61
  start-page: 2839
  year: 1996
  ident: C8NP00075A-(cit65)/*[position()=1]
  publication-title: J. Org. Chem.
  doi: 10.1021/jo952053i
– volume: 17
  start-page: 4486
  year: 2015
  ident: C8NP00075A-(cit15)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.5b02149
– volume: 12
  start-page: 2142
  year: 2017
  ident: C8NP00075A-(cit77)/*[position()=1]
  publication-title: Chem.–Asian J.
  doi: 10.1002/asia.201700442
– volume: 111
  start-page: 8013
  year: 2014
  ident: C8NP00075A-(cit21)/*[position()=1]
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1401073111
– volume: 118
  start-page: 9984
  year: 1996
  ident: C8NP00075A-(cit4)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja9615278
– volume: 38
  start-page: 3133
  year: 2009
  ident: C8NP00075A-(cit68)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/b901177n
– start-page: 173674
  year: 2017
  ident: C8NP00075A-(cit71)/*[position()=1]
  publication-title: bioRxiv
– volume: 113
  start-page: 5515
  year: 2013
  ident: C8NP00075A-(cit76)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr300436a
– volume: 131
  start-page: 7999
  year: 2009
  ident: C8NP00075A-(cit41a)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja9005332
– volume: 41
  start-page: 1668
  year: 2002
  ident: C8NP00075A-(cit74)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO;2-Z
– volume: 9
  start-page: 587
  year: 2001
  ident: C8NP00075A-(cit44)/*[position()=1]
  publication-title: Structure
  doi: 10.1016/S0969-2126(01)00618-9
– volume: 10
  start-page: 7503
  year: 2012
  ident: C8NP00075A-(cit56)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/c2ob25827g
– volume: 69
  start-page: 500
  year: 2016
  ident: C8NP00075A-(cit36)/*[position()=1]
  publication-title: J. Antibiot.
  doi: 10.1038/ja.2016.67
– volume: 16
  start-page: 2294
  year: 2015
  ident: C8NP00075A-(cit52)/*[position()=1]
  publication-title: ChemBioChem
  doi: 10.1002/cbic.201500386
– volume: 14
  start-page: 5388
  year: 2012
  ident: C8NP00075A-(cit12)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/ol302265z
– volume: 50
  start-page: 7476
  year: 2011
  ident: C8NP00075A-(cit43)/*[position()=1]
  publication-title: Biochemistry
  doi: 10.1021/bi2009739
– volume: 422
  start-page: 185
  year: 2003
  ident: C8NP00075A-(cit28a)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/nature01454
– volume: 13
  start-page: 6985
  year: 2007
  ident: C8NP00075A-(cit55)/*[position()=1]
  publication-title: Chem.–Eur. J.
  doi: 10.1002/chem.200700038
– volume: 107
  start-page: 8160
  year: 1985
  ident: C8NP00075A-(cit79)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00312a058
– volume: 139
  start-page: 10972
  year: 2017
  ident: C8NP00075A-(cit46c)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.7b05060
– volume: 13
  start-page: 10527
  year: 2015
  ident: C8NP00075A-(cit51)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/C5OB01771H
– volume: 8
  start-page: 556
  year: 1969
  ident: C8NP00075A-(cit78)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed. Engl.
  doi: 10.1002/anie.196905561
– volume: 38
  start-page: 3133
  year: 2009
  ident: C8NP00075A-(cit82)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/b901177n
– volume: 30
  start-page: 190
  year: 2012
  ident: C8NP00075A-(cit20)/*[position()=1]
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2109
– volume: 49
  start-page: 2444
  year: 2016
  ident: C8NP00075A-(cit15)/*[position()=2]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/acs.accounts.6b00375
– volume: 80
  start-page: 11672
  year: 2015
  ident: C8NP00075A-(cit38)/*[position()=1]
  publication-title: J. Org. Chem.
  doi: 10.1021/acs.joc.5b01951
– volume: 6
  start-page: 104
  year: 2014
  ident: C8NP00075A-(cit41c)/*[position()=1]
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.1843
– volume: 140
  start-page: 4227
  year: 2018
  ident: C8NP00075A-(cit14)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.8b01681
– volume: 115
  start-page: E848
  year: 2018
  ident: C8NP00075A-(cit58)/*[position()=1]
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1719368115
– volume-title: Dynamic Stereochemistry
  year: 1970
  ident: C8NP00075A-(cit6)/*[position()=1]
– volume: 1384
  start-page: 387
  year: 1998
  ident: C8NP00075A-(cit25)/*[position()=1]
  publication-title: Biochim. Biophys. Acta, Protein Struct. Biochim. Biophys. Acta, Protein Struct. Mol. Enzymol.
  doi: 10.1016/S0167-4838(98)00040-5
– volume: 460
  start-page: 210
  year: 2015
  ident: C8NP00075A-(cit53)/*[position()=1]
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2015.03.011
– volume: 15
  start-page: 2349
  year: 2014
  ident: C8NP00075A-(cit85)/*[position()=1]
  publication-title: ChemBioChem
  doi: 10.1002/cbic.201402373
– volume: 38
  start-page: 3133
  year: 2009
  ident: C8NP00075A-(cit11)/*[position()=1]
  publication-title: Chem. Soc. Rev.
  doi: 10.1039/b901177n
– volume-title: Comprehensive Natural Products II
  year: 2010
  ident: C8NP00075A-(cit22b)/*[position()=1]
– volume: 84
  start-page: 205
  year: 1984
  ident: C8NP00075A-(cit73)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr00061a001
– volume: 49
  start-page: 38393
  year: 2000
  ident: C8NP00075A-(cit27)/*[position()=1]
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M003119200
– volume: 8
  start-page: 4589
  year: 2010
  ident: C8NP00075A-(cit41b)/*[position()=1]
  publication-title: Org. Biomol. Chem.
  doi: 10.1039/c0ob00167h
– volume: 1
  start-page: 17
  year: 1968
  ident: C8NP00075A-(cit1a)/*[position()=1]
  publication-title: Acc. Chem. Res.
  doi: 10.1021/ar50001a003
– volume: 127
  start-page: 15002
  year: 2005
  ident: C8NP00075A-(cit42)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja055871t
– volume: 329
  start-page: 309
  year: 2010
  ident: C8NP00075A-(cit16)/*[position()=1]
  publication-title: Science
  doi: 10.1126/science.1190239
– volume: D60
  start-page: 1187
  year: 2004
  ident: C8NP00075A-(cit28b)/*[position()=1]
  publication-title: Acta Crystallogr.
– volume: 21
  start-page: 321
  year: 2004
  ident: C8NP00075A-(cit22a)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/B305068H
– volume: 11
  start-page: 259
  year: 2015
  ident: C8NP00075A-(cit32)/*[position()=1]
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1769
– volume: 109
  start-page: 12860
  year: 2012
  ident: C8NP00075A-(cit7)/*[position()=1]
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1209316109
– volume: 137
  start-page: 15366
  year: 2015
  ident: C8NP00075A-(cit69)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.5b10136
– volume: 28
  start-page: 4383
  year: 2017
  ident: C8NP00075A-(cit83)/*[position()=1]
  publication-title: Synthesis
  doi: 10.1055/s-0036-1590870
– volume-title: The Conservation of Orbital Symmetry
  year: 1970
  ident: C8NP00075A-(cit1)/*[position()=3]
– volume: 117
  start-page: 5367
  year: 2017
  ident: C8NP00075A-(cit37)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/acs.chemrev.6b00578
– volume: 119
  start-page: 10255
  year: 1997
  ident: C8NP00075A-(cit50)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja9643331
– volume-title: Classics in Total Synthesis: Targets, Strategies, Mechanisms
  year: 1996
  ident: C8NP00075A-(cit9)/*[position()=1]
– volume: 133
  start-page: 12342
  year: 2011
  ident: C8NP00075A-(cit45)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja2034969
– volume: 122
  start-page: 11519
  year: 2000
  ident: C8NP00075A-(cit23)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja003216+
– volume: 41
  start-page: 1668
  year: 2002
  ident: C8NP00075A-(cit9)/*[position()=3]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO;2-Z
– volume: 52
  start-page: 6472
  year: 2013
  ident: C8NP00075A-(cit26)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201302406
– volume: 89
  start-page: 679
  year: 2017
  ident: C8NP00075A-(cit47b)/*[position()=1]
  publication-title: Pure Appl. Chem.
  doi: 10.1515/pac-2017-0104
– volume: 57
  start-page: 3087
  year: 2018
  ident: C8NP00075A-(cit87)/*[position()=1]
  publication-title: Biochemistry
  doi: 10.1021/acs.biochem.7b01161
– volume: 140
  start-page: 3061
  year: 2018
  ident: C8NP00075A-(cit86)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.7b13562
– volume: 137
  start-page: 572
  year: 2015
  ident: C8NP00075A-(cit33)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja510711x
– volume: 67
  start-page: 4250
  year: 2002
  ident: C8NP00075A-(cit19)/*[position()=1]
  publication-title: J. Org. Chem.
  doi: 10.1021/jo011180d
– volume: 92
  start-page: 1021
  year: 1992
  ident: C8NP00075A-(cit80)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr00013a014
– volume: 522
  start-page: 497
  year: 2017
  ident: C8NP00075A-(cit46b)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/nature14560
– volume: 138
  start-page: 15837
  year: 2016
  ident: C8NP00075A-(cit54)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/jacs.6b10452
– volume: 42
  start-page: 3078
  year: 2003
  ident: C8NP00075A-(cit62)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.200200534
– volume: 39
  start-page: 44
  year: 2000
  ident: C8NP00075A-(cit75)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L
– volume: 83
  start-page: 38
  year: 2005
  ident: C8NP00075A-(cit30)/*[position()=1]
  publication-title: Chem. Eng. News
  doi: 10.1021/cen-v083n019.p038
– volume: 124
  start-page: 1130
  year: 2002
  ident: C8NP00075A-(cit59)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja016622h
– volume: 262
  start-page: 204
  year: 1993
  ident: C8NP00075A-(cit17)/*[position()=1]
  publication-title: Science
  doi: 10.1126/science.8211138
– volume: 10
  start-page: 50
  year: 2014
  ident: C8NP00075A-(cit84)/*[position()=1]
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.1385
– volume: 2003
  start-page: 0961
  year: 2003
  ident: C8NP00075A-(cit81)/*[position()=1]
  publication-title: Synthesis
  doi: 10.1055/s-2003-39171
– volume: 127
  start-page: 3577
  year: 2005
  ident: C8NP00075A-(cit29)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja043905b
– volume: 8
  start-page: 781
  year: 1969
  ident: C8NP00075A-(cit1b)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed. Engl.
  doi: 10.1002/anie.196907811
– volume: 47
  start-page: 7592
  year: 2008
  ident: C8NP00075A-(cit47a)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.200800918
– volume: 56
  start-page: 9062
  year: 2017
  ident: C8NP00075A-(cit72)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201703932
– volume: 108
  start-page: 554
  year: 1986
  ident: C8NP00075A-(cit3)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja00263a059
– volume: 78
  start-page: 2657
  year: 1956
  ident: C8NP00075A-(cit8)/*[position()=2]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01592a102
– volume: 57
  start-page: 952
  year: 2018
  ident: C8NP00075A-(cit13b)/*[position()=1]
  publication-title: Angew. Chem., Int. Ed.
  doi: 10.1002/anie.201711482
– volume: 31
  start-page: 1175
  year: 2014
  ident: C8NP00075A-(cit48)/*[position()=1]
  publication-title: Nat. Prod. Rep.
  doi: 10.1039/C4NP00031E
– volume: 19
  start-page: 5150
  year: 2017
  ident: C8NP00075A-(cit10)/*[position()=1]
  publication-title: Org. Lett.
  doi: 10.1021/acs.orglett.7b02434
– volume: 549
  start-page: 502
  year: 2017
  ident: C8NP00075A-(cit66)/*[position()=1]
  publication-title: Nature
  doi: 10.1038/nature23882
– volume: 13
  start-page: 467
  year: 2017
  ident: C8NP00075A-(cit70)/*[position()=1]
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2327
– volume: 78
  start-page: 2023
  year: 1956
  ident: C8NP00075A-(cit8)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01590a079
– volume: 62
  start-page: 441
  year: 1940
  ident: C8NP00075A-(cit67)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja01859a055
– volume: 2
  start-page: 1
  year: 1958
  ident: C8NP00075A-(cit8)/*[position()=3]
  publication-title: Tetrahedron
  doi: 10.1016/0040-4020(58)88022-9
– volume: 5
  start-page: 679
  year: 2013
  ident: C8NP00075A-(cit13a)/*[position()=1]
  publication-title: Nat. Chem.
  doi: 10.1038/nchem.1694
– volume: 106
  start-page: 3468
  year: 2006
  ident: C8NP00075A-(cit49)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr0503097
– start-page: 1321
  year: 1995
  ident: C8NP00075A-(cit24)/*[position()=1]
  publication-title: J. Chem. Soc., Chem. Commun.
  doi: 10.1039/C39950001321
– volume: 135
  start-page: 17638
  year: 2013
  ident: C8NP00075A-(cit46a)/*[position()=1]
  publication-title: J. Am. Chem. Soc.
  doi: 10.1021/ja409928z
– volume: 1
  start-page: 255
  year: 2000
  ident: C8NP00075A-(cit18)/*[position()=1]
  publication-title: ChemBioChem
  doi: 10.1002/1439-7633(20001117)1:4<255::AID-CBIC255>3.0.CO;2-S
– volume: 75
  start-page: 651
  year: 1975
  ident: C8NP00075A-(cit60)/*[position()=1]
  publication-title: Chem. Rev.
  doi: 10.1021/cr60298a001
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Snippet Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this...
Covering: 2000 to 2018 Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this...
Pericyclic reactions are a distinct class of reactions that have wide synthetic utility. Before the recent discoveries described in this review,...
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SubjectTerms Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
biosynthesis
Catalysis
catalytic activity
chemical reactions
Cyclization
enzymes
Enzymes - chemistry
Enzymes - metabolism
Naphthalenes - chemistry
Naphthalenes - metabolism
Protein Conformation
Title The expanding world of biosynthetic pericyclases: cooperation of experiment and theory for discovery
URI https://www.ncbi.nlm.nih.gov/pubmed/30311924
https://www.proquest.com/docview/2119935322
https://www.proquest.com/docview/2271800206
https://pubmed.ncbi.nlm.nih.gov/PMC6461539
Volume 36
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