Fast calculation of nanodosimetric quantities in treatment planning of proton and ion therapy

• Published in: Physics in medicine & biology Vol. 63; no. 23; p. 235015
• Main Authors: Ramos-Méndez, José, Burigo, Lucas N, Schulte, Reinhard, Chuang, Cynthia, Faddegon, Bruce
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 28.11.2018
• Subjects: carbon-ion therapy; efficient computation; Humans; Monte Carlo Method; Monte Carlo track-structure; nanodosimetry; Phantoms, Imaging; proton therapy; Proton Therapy - methods; Radiotherapy Dosage; Radiotherapy Planning, Computer-Assisted - methods; TOPAS-nBio; treatment planning

Details of the pattern of ionization formed by particle tracks extends knowledge of dose effects on the nanometer scale. Ionization detail (ID), frequently characterized by ionization cluster size distributions (ICSD), is obtained through time-consuming Monte Carlo (MC) track-structure simulations....