The Kinetics of L-Selectin Tethers and the Mechanics of Selectin-Mediated Rolling

• Published in: The Journal of cell biology Vol. 138; no. 5; pp. 1169 - 1180
• Main Authors: Alon, Ronen, Chen, Shuqi, Puri, Kamal D., Finger, Erik B., Springer, Timothy A.
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 08.09.1997; The Rockefeller University Press
• Subjects: Adhesive bonding; Antigens, Surface - isolation & purification; Antigens, Surface - physiology; Cell Adhesion; Cell Communication; Cellular biology; Chemotaxis, Leukocyte; E-Selectin - physiology; Elasticity; Flow velocity; Humans; Kinetics; L-Selectin - physiology; Leukocytes; Ligands; Membrane Proteins; Models, Biological; Neutrophils; Neutrophils - physiology; P-Selectin - physiology; Palatine Tonsil; Receptors, Lymphocyte Homing - physiology; Selectins; Shear stress; Stress, Mechanical; Time Factors; Tin; Velocity

Two mechanisms have been proposed for regulating rolling velocities on selectins. These are (a) the intrinsic kinetics of bond dissociation, and (b) the reactive compliance, i.e., the susceptibility of the bond dissociation reaction to applied force. To determine which of these mechanisms explains t...