The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

• Published in: Evidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Shang, Xuejun, Yan, Zechen, Zhang, Guowei, Cai, Hongcai
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Apoptosis; Benign; Cancer therapies; Caspase; Caspase-3; Cell growth; Drug dosages; Dutasteride; Finasteride; Geriatrics; Health aspects; Herbal medicine; Hyperplasia; Hypertrophy; Inflammation; Interleukin 8; Laboratory animals; Medical research; Medicine; Medicine, Botanic; Medicine, Herbal; Older people; Oxidative stress; Pharmaceuticals; Proliferating cell nuclear antigen; Propionic acid; Prostate; Rats; Rodents; Testosterone; Testosterone propionate; Tumor necrosis factor-α; Urology; China
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2018/5367814

Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.