Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity

• Published in: Function (Oxford, England) Vol. 4; no. 1; p. zqac065
• Main Authors: Pearson, Adam, Haenni, Dominik, Bouitbir, Jamal, Hunt, Matthew, Payne, Brendan A I, Sachdeva, Ashwin, Hung, Rachel K Y, Post, Frank A, Connolly, John, Nlandu-Khodo, Stellor, Jankovic, Nevena, Bugarski, Milica, Hall, Andrew M
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 2023
• Subjects: Antiviral Agents - metabolism; Humans; Kidney; Metabolomics; Mitochondria; Renal Insufficiency - drug therapy; Tenofovir - adverse effects; kidney; tenofovir; drug toxicity; imaging; mitochondria

Abstract Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting the need for better experimental models and methodological approaches. Most nephrotoxins damage the proximal tubule (PT), causing functional i...