Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil?

• Published in: Biomedicines Vol. 9; no. 1; p. 74
• Main Authors: Popova, Tatyana V., Pyshnaya, Inna A., Zakharova, Olga D., Akulov, Andrey E., Shevelev, Oleg B., Poletaeva, Julia, Zavjalov, Evgenii L., Silnikov, Vladimir N., Ryabchikova, Elena I., Godovikova, Tatyana S.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.01.2021; MDPI
• Subjects: Albumin; albumin theranostic conjugates; Antitumor agents; Boron; boronated albumin conjugate; Brain cancer; Cancer therapies; Chemotherapy; Cytotoxicity; Drug delivery systems; Drug development; fluorescence-based molecular imaging; gold nanoparticles; Human serum albumin; Labeling; Magnetic resonance imaging; Nanoparticles; Spatial distribution; trifluorothymidine-albumin conjugate; St Louis Missouri; United Kingdom > UK; United States > US; Japan; Germany; Russia; trifluorothymidine-albumin conjugate; albumin theranostic conjugates; fluorescence-based molecular imaging; boronated albumin conjugate; gold nanoparticles

Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained...