Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil?

Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained...

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Published inBiomedicines Vol. 9; no. 1; p. 74
Main Authors Popova, Tatyana V., Pyshnaya, Inna A., Zakharova, Olga D., Akulov, Andrey E., Shevelev, Oleg B., Poletaeva, Julia, Zavjalov, Evgenii L., Silnikov, Vladimir N., Ryabchikova, Elena I., Godovikova, Tatyana S.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 13.01.2021
MDPI
Subjects
Albumin
albumin theranostic conjugates
Antitumor agents
Boron
boronated albumin conjugate
Brain cancer
Cancer therapies
Chemotherapy
Cytotoxicity
Drug delivery systems
Drug development
fluorescence-based molecular imaging
gold nanoparticles
Human serum albumin
Labeling
Magnetic resonance imaging
Nanoparticles
Spatial distribution
trifluorothymidine-albumin conjugate
St Louis Missouri
United Kingdom > UK
United States > US
Japan
Germany
Russia
trifluorothymidine-albumin conjugate
albumin theranostic conjugates
fluorescence-based molecular imaging
boronated albumin conjugate
gold nanoparticles
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Abstract Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
AbstractList Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro- -dodecaborate (B H ) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro-closo-dodecaborate (B12H12) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. Herein, albumin-AuNP theranostic agents have been obtained by conjugation of an anticancer nucleotide trifluorothymidine (TFT) or a boron-neutron capture therapy drug undecahydro- closo -dodecaborate (B 12 H 12 ) to bimodal human serum albumin (HSA) followed by reacting of the albumin conjugates with AuNPs. In vitro studies have revealed a stronger cytotoxicity by the AuNPs decorated with the TFT-tagged bimodal HSA than by the boronated albumin conjugates. Despite long circulation time, lack of the significant accumulation in the tumor was observed for the AuNP theranostic conjugates. Our unique labelling strategy allows for monitoring of spatial distribution of the AuNPs theranostic in vivo in real time with high sensitivity, thus reducing the number of animals required for testing and optimizing new nanosystems as chemotherapeutic agents and boron-neutron capture therapy drug candidates.
Author Popova, Tatyana V.
Pyshnaya, Inna A.
Poletaeva, Julia
Ryabchikova, Elena I.
Godovikova, Tatyana S.
Silnikov, Vladimir N.
Zavjalov, Evgenii L.
Zakharova, Olga D.
Shevelev, Oleg B.
Akulov, Andrey E.
AuthorAffiliation 2 Institute of Cytology and Genetics, SB RAS, Lavrentiev ave. 10, 630090 Novosibirsk, Russia; akulov@bionet.nsc.ru (A.E.A.); shevelev@bionet.nsc.ru (O.B.S.); zavjalov@bionet.nsc.ru (E.L.Z.)
1 Institute of Chemical Biology and Fundamental Medicine, The Siberian Branch of the Russian Academy of Sciences, Lavrentiev ave. 8, 630090 Novosibirsk, Russia; io197724@gmail.com (T.V.P.); pyshnaya@niboch.nsc.ru (I.A.P.); garonna3@mail.ru (O.D.Z.); fabaceae@yandex.ru (J.P.); silnik@niboch.nsc.ru (V.N.S.); lenryab@niboch.nsc.ru (E.I.R.)
AuthorAffiliation_xml – name: 2 Institute of Cytology and Genetics, SB RAS, Lavrentiev ave. 10, 630090 Novosibirsk, Russia; akulov@bionet.nsc.ru (A.E.A.); shevelev@bionet.nsc.ru (O.B.S.); zavjalov@bionet.nsc.ru (E.L.Z.)
– name: 1 Institute of Chemical Biology and Fundamental Medicine, The Siberian Branch of the Russian Academy of Sciences, Lavrentiev ave. 8, 630090 Novosibirsk, Russia; io197724@gmail.com (T.V.P.); pyshnaya@niboch.nsc.ru (I.A.P.); garonna3@mail.ru (O.D.Z.); fabaceae@yandex.ru (J.P.); silnik@niboch.nsc.ru (V.N.S.); lenryab@niboch.nsc.ru (E.I.R.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33451058$$D View this record in MEDLINE/PubMed
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Keywords trifluorothymidine-albumin conjugate
albumin theranostic conjugates
fluorescence-based molecular imaging
boronated albumin conjugate
gold nanoparticles
Language English
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Snippet Multifunctional gold nanoparticles (AuNPs) may serve as a scaffold to integrate diagnostic and therapeutic functions into one theranostic system, thereby...
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StartPage 74
SubjectTerms Albumin
albumin theranostic conjugates
Antitumor agents
Boron
boronated albumin conjugate
Brain cancer
Cancer therapies
Chemotherapy
Cytotoxicity
Drug delivery systems
Drug development
fluorescence-based molecular imaging
gold nanoparticles
Human serum albumin
Labeling
Magnetic resonance imaging
Nanoparticles
Spatial distribution
trifluorothymidine-albumin conjugate
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Title Rational Design of Albumin Theranostic Conjugates for Gold Nanoparticles Anticancer Drugs: Where the Seed Meets the Soil?
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