Protective Effect of Pemafibrate Treatment against Diabetic Retinopathy in Spontaneously Diabetic Torii Fatty Rats

• Published in: Biological & pharmaceutical bulletin Vol. 47; no. 3; pp. 713 - 722
• Main Authors: Tanaka, Yoshiaki, Takagi, Rina, Mitou, Shingen, Shimmura, Machiko, Hasegawa, Tetsuya, Amarume, Jota, Shinohara, Masami, Kageyama, Yasushi, Sasase, Tomohiko, Ohta, Takeshi, Muramatsu, Shin-ichi, Kakehashi, Akihiro, Kaburaki, Toshikatsu
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 27.03.2024; Japan Science and Technology Agency
• Subjects: Animals; Aquaporin 4; Benzoxazoles; Blood levels; Body weight; Butyrates; Cholesterol; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diabetic retinopathy; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - prevention & control; Disease Models, Animal; Electroretinograms; Food consumption; High density lipoprotein; pemafibrate; Rats; Rats, Sprague-Dawley; Retina; Retinopathy; Spontaneously Diabetic Torii fatty rat model; Spontaneously Diabetic Torii fatty rat model; pemafibrate; aquaporin-4; diabetic retinopathy

Diabetic retinopathy (DR) can cause visual impairment and blindness, and the increasing global prevalence of diabetes underscores the need for effective therapies to prevent and treat DR. Therefore, this study aimed to evaluate the protective effect of pemafibrate treatment against DR, using a Spont...