Circulating Human Hepcidin-25 Concentrations Display a Diurnal Rhythm, Increase with Prolonged Fasting, and Are Reduced by Growth Hormone Administration

• Published in: Clinical chemistry (Baltimore, Md.) Vol. 58; no. 8; pp. 1225 - 1232
• Main Authors: TROUTT, Jason S, RUDLING, Mats, PERSSON, Lena, STAHLE, Lars, ANGELIN, Bo, BUTTERFIELD, Anthony M, SCHADE, Andrew E, GUOQING CAO, KONRAD, Robert J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Association for Clinical Chemistry 01.08.2012; Oxford University Press
• Subjects: Adult; Aged; Amino acids; Analytical, structural and metabolic biochemistry; Antimicrobial Cationic Peptides - blood; Biological and medical sciences; Birds; Chronic illnesses; Circadian Rhythm; Diurnal variations; Enzyme-Linked Immunosorbent Assay; Erythropoiesis; Fasting; Fundamental and applied biological sciences. Psychology; Hepcidins; Human Growth Hormone - therapeutic use; Humans; Immunoassay; Investigative techniques, diagnostic techniques (general aspects); Iron; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Molecular biophysics; Reference Values; Rodents; Sensitivity and Specificity; Sleep; Sleep Deprivation; Studies; Time Factors; Young Adult; Human; Fasting; Rhythm; Increase; Biochemistry; Concentration; Somatotropin; Reduction; Adenohypophyseal hormone; Clinical biology; Molecular biology; Fast; Hepcidin; Prolonged

Hepcidin-25 reduces iron absorption by binding to the intestinal iron transporter ferroportin and causing its degradation. Currently, little is known about the basal regulation of circulating hepcidin-25. In addition, although erythropoietin administration has been reported to decrease the circulati...