An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis

• Published in: Cell Vol. 175; no. 2; pp. 530 - 543.e24
• Main Authors: Roediger, Ben, Lee, Quintin, Tikoo, Shweta, Cobbin, Joanna C.A., Henderson, James M., Jormakka, Mika, O’Rourke, Matthew B., Padula, Matthew P., Pinello, Natalia, Henry, Marisa, Wynne, Maria, Santagostino, Sara F., Brayton, Cory F., Rasmussen, Lorna, Lisowski, Leszek, Tay, Szun S., Harris, David C., Bertram, John F., Dowling, John P., Bertolino, Patrick, Lai, Jack H., Wu, Wengen, Bachovchin, William W., Wong, Justin J.-L., Gorrell, Mark D., Shaban, Babak, Holmes, Edward C., Jolly, Christopher J., Monette, Sébastien, Weninger, Wolfgang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.10.2018
• Subjects: adaptive immunity; Animals; Australia; chronic kidney disease; disease course; Disease Progression; Female; fibrosis; Fibrosis - pathology; Fibrosis - virology; histopathology; Humans; inclusion body nephropathy; Kidney - metabolism; Kidney - physiology; kidneys; Male; metagenomics; Mice; Mice, Inbred C57BL; Nephritis, Interstitial - physiopathology; Nephritis, Interstitial - virology; North America; Parvoviridae; Parvoviridae Infections - metabolism; parvovirus; Parvovirus - isolation & purification; Parvovirus - pathogenicity; pathogens; Protoparvovirus; renal failure; tubulointerstitial fibrosis; viral metagenomics; viruses; Australia; North America; chronic kidney disease; tubulointerstitial fibrosis; inclusion body nephropathy; Parvoviridae; fibrosis; parvovirus; viral metagenomics

The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the...