An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis
The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the...
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| Published in | Cell Vol. 175; no. 2; pp. 530 - 543.e24 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Elsevier Inc
04.10.2018
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| Abstract | The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed “mouse kidney parvovirus” (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.
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•Inclusion body nephropathy is caused by mouse kidney parvovirus (MKPV)•MKPV is widely distributed in animal facilities in Australia and North America•MKPV is highly divergent from other mouse parvoviruses•Uncontrolled MKPV infection in immunocompromised mice results in renal failure
A kidney parvovirus found in multiple laboratory mouse colonies causes spontaneous nephropathy and represents a new tool for studying chronic kidney disease. |
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| AbstractList | The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed “mouse kidney parvovirus” (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans.The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed “mouse kidney parvovirus” (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. [Display omitted] •Inclusion body nephropathy is caused by mouse kidney parvovirus (MKPV)•MKPV is widely distributed in animal facilities in Australia and North America•MKPV is highly divergent from other mouse parvoviruses•Uncontrolled MKPV infection in immunocompromised mice results in renal failure A kidney parvovirus found in multiple laboratory mouse colonies causes spontaneous nephropathy and represents a new tool for studying chronic kidney disease. The occurrence of a spontaneous nephropathy with intranuclear inclusions in laboratory mice has puzzled pathologists for over 4 decades, because its etiology remains elusive. The condition is more severe in immunodeficient animals, suggesting an infectious cause. Using metagenomics, we identify the causative agent as an atypical virus, termed "mouse kidney parvovirus" (MKPV), belonging to a divergent genus of Parvoviridae. MKPV was identified in animal facilities in Australia and North America, is transmitted via a fecal-oral or urinary-oral route, and is controlled by the adaptive immune system. Detailed analysis of the clinical course and histopathological features demonstrated a stepwise progression of pathology ranging from sporadic tubular inclusions to tubular degeneration and interstitial fibrosis and culminating in renal failure. In summary, we identify a widely distributed pathogen in laboratory mice and establish MKPV-induced nephropathy as a new tool for elucidating mechanisms of tubulointerstitial fibrosis that shares molecular features with chronic kidney disease in humans. |
| Author | Wynne, Maria Brayton, Cory F. Santagostino, Sara F. Padula, Matthew P. Jormakka, Mika Henry, Marisa Lisowski, Leszek Jolly, Christopher J. Rasmussen, Lorna Lai, Jack H. Weninger, Wolfgang Bertolino, Patrick Shaban, Babak Harris, David C. Lee, Quintin Dowling, John P. Bachovchin, William W. Gorrell, Mark D. Pinello, Natalia Wu, Wengen Holmes, Edward C. Henderson, James M. Monette, Sébastien Tay, Szun S. Bertram, John F. O’Rourke, Matthew B. Cobbin, Joanna C.A. Wong, Justin J.-L. Roediger, Ben Tikoo, Shweta |
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James M. organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 6 givenname: Mika surname: Jormakka fullname: Jormakka, Mika organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 7 givenname: Matthew B. surname: O’Rourke fullname: O’Rourke, Matthew B. organization: Mass Spectrometry Core Facility, University of Sydney, Sydney, NSW 2006, Australia – sequence: 8 givenname: Matthew P. surname: Padula fullname: Padula, Matthew P. organization: Proteomics Core Facility, University of Technology Sydney, Ultimo, NSW 2007, Australia – sequence: 9 givenname: Natalia surname: Pinello fullname: Pinello, Natalia organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 10 givenname: Marisa surname: Henry fullname: Henry, Marisa organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 11 givenname: Maria surname: Wynne fullname: Wynne, Maria organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 12 givenname: Sara F. surname: Santagostino fullname: Santagostino, Sara F. organization: Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA – sequence: 13 givenname: Cory F. surname: Brayton fullname: Brayton, Cory F. organization: Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 14 givenname: Lorna surname: Rasmussen fullname: Rasmussen, Lorna organization: Cerberus Sciences, Thebarton, SA 5031, Australia – sequence: 15 givenname: Leszek surname: 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Patrick surname: Bertolino fullname: Bertolino, Patrick organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 21 givenname: Jack H. surname: Lai fullname: Lai, Jack H. organization: Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA – sequence: 22 givenname: Wengen surname: Wu fullname: Wu, Wengen organization: Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA – sequence: 23 givenname: William W. surname: Bachovchin fullname: Bachovchin, William W. organization: Sackler School of Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA – sequence: 24 givenname: Justin J.-L. surname: Wong fullname: Wong, Justin J.-L. organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 25 givenname: Mark D. surname: Gorrell fullname: Gorrell, Mark D. organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 26 givenname: Babak surname: Shaban fullname: Shaban, Babak organization: Australian Genomics Research Facility, Parkville, VIC 3000, Australia – sequence: 27 givenname: Edward C. surname: Holmes fullname: Holmes, Edward C. organization: Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Faculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia – sequence: 28 givenname: Christopher J. surname: Jolly fullname: Jolly, Christopher J. organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia – sequence: 29 givenname: Sébastien surname: Monette fullname: Monette, Sébastien organization: Laboratory of Comparative Pathology, Center of Comparative Medicine and Pathology, Memorial Sloan Kettering Cancer Center, The Rockefeller University, Weill Cornell Medicine, New York, NY 10065, USA – sequence: 30 givenname: Wolfgang surname: Weninger fullname: Weninger, Wolfgang email: w.weninger@centenary.org.au organization: Centenary Institute, Faculty of Medicine and Health, The University of Sydney, Camperdown, NSW 2050, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30220458$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1093/nar/gkt214 10.1080/10635150390235520 10.1038/nrneph.2015.215 10.1093/ilar.49.3.277 10.14806/ej.17.1.200 10.1093/molbev/mst010 10.1002/dvg.20335 10.1371/journal.pone.0017288 10.1007/s00705-013-1914-1 10.1093/bioinformatics/btp348 10.1016/0092-8674(94)90169-4 10.1172/JCI42004 10.1038/srep26235 10.4049/jimmunol.171.12.6556 10.1128/CMR.9.1.18 10.1172/JCI72267 10.1177/0300985817698210 10.1152/ajprenal.00318.2013 10.1126/scitranslmed.aac7071 10.1101/cshperspect.a012989 10.1038/nbt.1883 10.1093/ndt/gft071 10.1016/0092-8674(91)90163-S 10.1038/ni.3006 10.3390/vetsci2020084 10.1056/NEJMe1307013 10.1093/nar/gkv1145 10.1016/j.kint.2015.10.015 10.1093/nar/gkg595 10.1006/cimm.2001.1895 10.1016/j.ddmod.2010.08.002 10.1038/nbt.3122 10.1038/ki.2009.86 10.1038/ni.2584 10.1101/gr.074492.107 10.1016/S0272-6386(12)80312-X 10.1093/bioinformatics/bts174 10.1093/bioinformatics/bts094 10.1093/bioinformatics/btp698 10.1186/1755-1536-5-S1-S24 10.1093/nar/gkv007 10.1093/bioinformatics/btp120 10.1038/nrneph.2016.163 10.1016/j.cell.2007.12.033 10.1038/ncpneph0319 10.1038/nrd4592 10.4049/jimmunol.165.6.3284 10.1016/S0140-6736(16)32064-5 10.1038/342559a0 10.1155/2016/1319578 10.2217/bmm.14.90 10.1046/j.1523-1755.2002.00433.x 10.1177/0300985811431446 10.1099/jgv.0.000671 10.1186/gb-2004-5-10-r80 10.1016/j.ab.2010.01.014 10.1002/rmv.648 10.1097/TP.0b013e318197c17d |
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| Keywords | chronic kidney disease tubulointerstitial fibrosis inclusion body nephropathy Parvoviridae fibrosis parvovirus viral metagenomics |
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| References | Cook, Oganesian, Harumal, Basten, Brink, Jolly (bib12) 2003; 171 Sakaue-Sawano, Kurokawa, Morimura, Hanyu, Hama, Osawa, Kashiwagi, Fukami, Miyata, Miyoshi (bib46) 2008; 132 Viau, El Karoui, Laouari, Burtin, Nguyen, Mori, Pillebout, Berger, Mak, Knebelmann (bib57) 2010; 120 Liptak, Kemeny, Ivanyi (bib33) 2006; 2 Martin (bib34) 2011; 17 Schmieder, Edwards (bib50) 2011; 6 Webster, Nagler, Morton, Masson (bib59) 2016; 389 Barthold, Percy, Griffey (bib4) 2016 Becker, Hewitson (bib6) 2013; 28 Liao, Smyth, Shi (bib31) 2013; 41 Cotmore, Agbandje-McKenna, Chiorini, Mukha, Pintel, Qiu, Soderlund-Venermo, Tattersall, Tijssen, Gatherer, Davison (bib14) 2014; 159 Becher, Schlitzer, Chen, Mair, Sumatoh, Teng, Low, Ruedl, Riccardi-Castagnoli, Poidinger (bib5) 2014; 15 Cotmore, Tattersall (bib13) 2013; 5 Muzumdar, Tasic, Miyamichi, Li, Luo (bib36) 2007; 45 Haase, Bellomo, Albert, Vanpoucke, Thomas, Laroy, Verleysen, Kropf, Kuppe, Hetzer, Haase-Fielitz (bib22) 2014; 8 Zuker (bib63) 2003; 31 Okello, Zurek, Devault, Kuch, Okwi, Sewankambo, Bimenya, Poinar, Poinar (bib39) 2010; 400 Besselsen, Franklin, Livingston, Riley (bib7) 2008; 49 Chevalier, Forbes, Thornhill (bib11) 2009; 75 Pircher, Bürki, Lang, Hengartner, Zinkernagel (bib42) 1989; 342 Souza, Romeiro, Fumagalli, Modha, de Araujo, Queiroz, Durigon, Figueiredo, Murcia, Gifford (bib53) 2017; 98 Ingelfinger, Alexander (bib25) 2013; 369 Treuting, Clifford, Sellers, Brayton (bib55) 2012; 49 Ashhurst, T.M. (2017). tSNEplots (University of Sydney). Schaefer, Schaefer, Kappler, Marrack, Kedl (bib49) 2001; 214 Schönrich, Kalinke, Momburg, Malissen, Schmitt-Verhulst, Malissen, Hämmerling, Arnold (bib51) 1991; 65 Santagostino, Arbona, Nashat, White, Monette (bib47) 2017; 54 Pertea, Pertea, Antonescu, Chang, Mendell, Salzberg (bib41) 2015; 33 Ramos, Drachenberg, Wali, Hirsch (bib43) 2009; 87 Hogquist, Jameson, Heath, Howard, Bevan, Carbone (bib24) 1994; 76 Han, Bailly, Abichandani, Thadhani, Bonventre (bib23) 2002; 62 Schäck, Buettner, Wirth, Neunaber, Krettek, Hoffmann, Noack (bib48) 2016; 2016 Djudjaj, Papasotiriou, Bülow, Wagnerova, Lindenmeyer, Cohen, Strnad, Goumenos, Floege, Boor (bib15) 2016; 89 Duffield (bib16) 2014; 124 Lipson, Wong, Teng, Spong (bib32) 2012; 5 Nanthakumar, Hatley, Lemma, Gauldie, Marshall, Macdonald (bib37) 2015; 14 Arvaniti, Moulos, Vakrakou, Chatziantoniou, Chadjichristos, Kavvadas, Charonis, Politis (bib1) 2016; 6 Vizcaíno, Csordas, del-Toro, Dianes, Griss, Lavidas, Mayer, Perez-Riverol, Reisinger, Ternent (bib58) 2016; 44 Li, Durbin (bib30) 2010; 26 Trapnell, Pachter, Salzberg (bib54) 2009; 25 Yang, Zuo, Fogo (bib60) 2010; 7 Guindon, Gascuel (bib21) 2003; 52 Gentleman, Carey, Bates, Bolstad, Dettling, Dudoit, Ellis, Gautier, Ge, Gentry (bib18) 2004; 5 Ritchie, Phipson, Wu, Hu, Law, Shi, Smyth (bib44) 2015; 43 Nath (bib38) 1992; 20 Glassock, Warnock, Delanaye (bib19) 2017; 13 Baze, Steinbach, Fleetwood, Blanchard, Barnhart, McArthur (bib3) 2006; 56 Peng, Leung, Yiu, Chin (bib40) 2012; 28 Katoh, Standley (bib28) 2013; 30 Unutmaz, Xiang, Sunshine, Campbell, Butcher, Littman (bib56) 2000; 165 Zerbino, Birney (bib61) 2008; 18 Capella-Gutiérrez, Silla-Martínez, Gabaldón (bib10) 2009; 25 Grabherr, Haas, Yassour, Levin, Thompson, Amit, Adiconis, Fan, Raychowdhury, Zeng (bib20) 2011; 29 Fredricks, Relman (bib17) 1996; 9 Roediger, Kyle, Yip, Sumaria, Guy, Kim, Mitchell, Tay, Jain, Forbes-Blom (bib45) 2013; 14 Brown (bib9) 2010; 20 McInnes, Bennett, O’Hara, Rasmussen, Fung, Nicholls, Slaven, Stevenson (bib35) 2015; 2 Schulz, Zerbino, Vingron, Birney (bib52) 2012; 28 Kassianos, Wang, Sampangi, Muczynski, Healy, Wilkinson (bib27) 2013; 305 Brayton (bib8) 2007 Zhou, Liu (bib62) 2016; 12 Ju, Nair, Smith, Zhu, Shedden, Song, Mariani, Eichinger, Berthier, Randolph (bib26) 2015; 7 Krueger (bib29) 2012 McInnes (10.1016/j.cell.2018.08.013_bib35) 2015; 2 Yang (10.1016/j.cell.2018.08.013_bib60) 2010; 7 Capella-Gutiérrez (10.1016/j.cell.2018.08.013_bib10) 2009; 25 Martin (10.1016/j.cell.2018.08.013_bib34) 2011; 17 Gentleman (10.1016/j.cell.2018.08.013_bib18) 2004; 5 Hogquist (10.1016/j.cell.2018.08.013_bib24) 1994; 76 Zuker (10.1016/j.cell.2018.08.013_bib63) 2003; 31 Vizcaíno (10.1016/j.cell.2018.08.013_bib58) 2016; 44 Schaefer (10.1016/j.cell.2018.08.013_bib49) 2001; 214 Ju (10.1016/j.cell.2018.08.013_bib26) 2015; 7 Djudjaj (10.1016/j.cell.2018.08.013_bib15) 2016; 89 Zerbino (10.1016/j.cell.2018.08.013_bib61) 2008; 18 Ritchie (10.1016/j.cell.2018.08.013_bib44) 2015; 43 Han (10.1016/j.cell.2018.08.013_bib23) 2002; 62 Chevalier (10.1016/j.cell.2018.08.013_bib11) 2009; 75 Arvaniti (10.1016/j.cell.2018.08.013_bib1) 2016; 6 Peng (10.1016/j.cell.2018.08.013_bib40) 2012; 28 Becker (10.1016/j.cell.2018.08.013_bib6) 2013; 28 Becher (10.1016/j.cell.2018.08.013_bib5) 2014; 15 Schulz (10.1016/j.cell.2018.08.013_bib52) 2012; 28 Besselsen (10.1016/j.cell.2018.08.013_bib7) 2008; 49 Grabherr (10.1016/j.cell.2018.08.013_bib20) 2011; 29 Viau (10.1016/j.cell.2018.08.013_bib57) 2010; 120 Ramos (10.1016/j.cell.2018.08.013_bib43) 2009; 87 Roediger (10.1016/j.cell.2018.08.013_bib45) 2013; 14 Brown (10.1016/j.cell.2018.08.013_bib9) 2010; 20 Liptak (10.1016/j.cell.2018.08.013_bib33) 2006; 2 Fredricks (10.1016/j.cell.2018.08.013_bib17) 1996; 9 Ingelfinger (10.1016/j.cell.2018.08.013_bib25) 2013; 369 Guindon (10.1016/j.cell.2018.08.013_bib21) 2003; 52 Cook (10.1016/j.cell.2018.08.013_bib12) 2003; 171 Okello (10.1016/j.cell.2018.08.013_bib39) 2010; 400 Trapnell (10.1016/j.cell.2018.08.013_bib54) 2009; 25 Schäck (10.1016/j.cell.2018.08.013_bib48) 2016; 2016 Treuting (10.1016/j.cell.2018.08.013_bib55) 2012; 49 Nanthakumar (10.1016/j.cell.2018.08.013_bib37) 2015; 14 Sakaue-Sawano (10.1016/j.cell.2018.08.013_bib46) 2008; 132 Barthold (10.1016/j.cell.2018.08.013_bib4) 2016 Lipson (10.1016/j.cell.2018.08.013_bib32) 2012; 5 Brayton (10.1016/j.cell.2018.08.013_bib8) 2007 Nath (10.1016/j.cell.2018.08.013_bib38) 1992; 20 Unutmaz (10.1016/j.cell.2018.08.013_bib56) 2000; 165 Baze (10.1016/j.cell.2018.08.013_bib3) 2006; 56 Li (10.1016/j.cell.2018.08.013_bib30) 2010; 26 Krueger (10.1016/j.cell.2018.08.013_bib29) 2012 10.1016/j.cell.2018.08.013_bib2 Liao (10.1016/j.cell.2018.08.013_bib31) 2013; 41 Katoh (10.1016/j.cell.2018.08.013_bib28) 2013; 30 Muzumdar (10.1016/j.cell.2018.08.013_bib36) 2007; 45 Zhou (10.1016/j.cell.2018.08.013_bib62) 2016; 12 Kassianos (10.1016/j.cell.2018.08.013_bib27) 2013; 305 Glassock (10.1016/j.cell.2018.08.013_bib19) 2017; 13 Souza (10.1016/j.cell.2018.08.013_bib53) 2017; 98 Pertea (10.1016/j.cell.2018.08.013_bib41) 2015; 33 Haase (10.1016/j.cell.2018.08.013_bib22) 2014; 8 Webster (10.1016/j.cell.2018.08.013_bib59) 2016; 389 Duffield (10.1016/j.cell.2018.08.013_bib16) 2014; 124 Schmieder (10.1016/j.cell.2018.08.013_bib50) 2011; 6 Pircher (10.1016/j.cell.2018.08.013_bib42) 1989; 342 Cotmore (10.1016/j.cell.2018.08.013_bib14) 2014; 159 Cotmore (10.1016/j.cell.2018.08.013_bib13) 2013; 5 Schönrich (10.1016/j.cell.2018.08.013_bib51) 1991; 65 Santagostino (10.1016/j.cell.2018.08.013_bib47) 2017; 54 30262845 - Nat Rev Nephrol. 2018 Dec;14(12):719 30290137 - Cell. 2018 Oct 4;175(2):310-311 |
| References_xml | – start-page: 623 year: 2007 end-page: 717 ident: bib8 article-title: Spontaneous diseases in commonly used mouse strains A2 publication-title: The Mouse in Biomedical Research – volume: 52 start-page: 696 year: 2003 end-page: 704 ident: bib21 article-title: A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood publication-title: Syst. Biol. – volume: 44 start-page: D447 year: 2016 end-page: D456 ident: bib58 article-title: 2016 update of the PRIDE database and its related tools publication-title: Nucleic Acids Res. – volume: 305 start-page: F1391 year: 2013 end-page: F1401 ident: bib27 article-title: Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease publication-title: Am. J. Physiol. Renal Physiol. – volume: 54 start-page: 855 year: 2017 end-page: 869 ident: bib47 article-title: Pathology of Aging in NOD scid gamma Female Mice publication-title: Vet. Pathol. – volume: 25 start-page: 1105 year: 2009 end-page: 1111 ident: bib54 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics – volume: 62 start-page: 237 year: 2002 end-page: 244 ident: bib23 article-title: Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury publication-title: Kidney Int. – volume: 132 start-page: 487 year: 2008 end-page: 498 ident: bib46 article-title: Visualizing spatiotemporal dynamics of multicellular cell-cycle progression publication-title: Cell – volume: 87 start-page: 621 year: 2009 end-page: 630 ident: bib43 article-title: The decade of polyomavirus BK-associated nephropathy: state of affairs publication-title: Transplantation – volume: 2016 start-page: 1319578 year: 2016 ident: bib48 article-title: Expression of CD24 in human bone marrow-derived mesenchymal stromal cells is regulated by TGFβ3 and induces a myofibroblast-like genotype publication-title: Stem Cells Int. – volume: 49 start-page: 277 year: 2008 end-page: 290 ident: bib7 article-title: Lurking in the shadows: emerging rodent infectious diseases publication-title: ILAR J. – volume: 30 start-page: 772 year: 2013 end-page: 780 ident: bib28 article-title: MAFFT multiple sequence alignment software version 7: improvements in performance and usability publication-title: Mol. Biol. Evol. – volume: 9 start-page: 18 year: 1996 end-page: 33 ident: bib17 article-title: Sequence-based identification of microbial pathogens: a reconsideration of Koch’s postulates publication-title: Clin. Microbiol. Rev. – volume: 342 start-page: 559 year: 1989 end-page: 561 ident: bib42 article-title: Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen publication-title: Nature – volume: 33 start-page: 290 year: 2015 end-page: 295 ident: bib41 article-title: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads publication-title: Nat. Biotechnol. – year: 2016 ident: bib4 article-title: Pathology of laboratory rodents and rabbits, Fourth Edition – volume: 13 start-page: 104 year: 2017 end-page: 114 ident: bib19 article-title: The global burden of chronic kidney disease: estimates, variability and pitfalls publication-title: Nat. Rev. Nephrol. – volume: 14 start-page: 693 year: 2015 end-page: 720 ident: bib37 article-title: Dissecting fibrosis: therapeutic insights from the small-molecule toolbox publication-title: Nat. Rev. Drug Discov. – volume: 28 start-page: 2432 year: 2013 end-page: 2438 ident: bib6 article-title: Animal models of chronic kidney disease: useful but not perfect publication-title: Nephrol. Dial. Transplant. – volume: 14 start-page: 564 year: 2013 end-page: 573 ident: bib45 article-title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells publication-title: Nat. Immunol. – volume: 26 start-page: 589 year: 2010 end-page: 595 ident: bib30 article-title: Fast and accurate long-read alignment with Burrows-Wheeler transform publication-title: Bioinformatics – volume: 98 start-page: 225 year: 2017 end-page: 229 ident: bib53 article-title: Chapparvoviruses occur in at least three vertebrate classes and have a broad biogeographic distribution publication-title: J. Gen. Virol. – volume: 159 start-page: 1239 year: 2014 end-page: 1247 ident: bib14 article-title: The family Parvoviridae publication-title: Arch. Virol. – volume: 2 start-page: 631 year: 2006 end-page: 636 ident: bib33 article-title: Primer: histopathology of polyomavirus-associated nephropathy in renal allografts publication-title: Nat. Clin. Pract. Nephrol. – volume: 25 start-page: 1972 year: 2009 end-page: 1973 ident: bib10 article-title: trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses publication-title: Bioinformatics – volume: 15 start-page: 1181 year: 2014 end-page: 1189 ident: bib5 article-title: High-dimensional analysis of the murine myeloid cell system publication-title: Nat. Immunol. – volume: 29 start-page: 644 year: 2011 end-page: 652 ident: bib20 article-title: Full-length transcriptome assembly from RNA-Seq data without a reference genome publication-title: Nat. Biotechnol. – volume: 214 start-page: 110 year: 2001 end-page: 122 ident: bib49 article-title: Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo publication-title: Cell. Immunol. – volume: 171 start-page: 6556 year: 2003 end-page: 6564 ident: bib12 article-title: Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions publication-title: J. Immunol. – volume: 7 start-page: 316ra193 year: 2015 ident: bib26 article-title: Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker publication-title: Sci. Transl. Med. – volume: 5 start-page: S24 year: 2012 ident: bib32 article-title: CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis publication-title: Fibrogenesis Tissue Repair – volume: 120 start-page: 4065 year: 2010 end-page: 4076 ident: bib57 article-title: Lipocalin 2 is essential for chronic kidney disease progression in mice and humans publication-title: J. Clin. Invest. – volume: 5 year: 2013 ident: bib13 article-title: Parvovirus diversity and DNA damage responses publication-title: Cold Spring Harb. Perspect. Biol. – volume: 400 start-page: 110 year: 2010 end-page: 117 ident: bib39 article-title: Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues publication-title: Anal. Biochem. – volume: 369 start-page: 84 year: 2013 end-page: 85 ident: bib25 article-title: One step closer to “Rejectostix” publication-title: N. Engl. J. Med. – volume: 2 start-page: 84 year: 2015 end-page: 96 ident: bib35 article-title: Intranuclear inclusions in renal tubular epithelium in immunodeficient mice stain with antibodies for bovine papillomavirus type 1 L1 protein publication-title: Vet. Sci. – year: 2012 ident: bib29 article-title: Trim Galore! – volume: 12 start-page: 68 year: 2016 end-page: 70 ident: bib62 article-title: Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis publication-title: Nat. Rev. Nephrol. – volume: 6 start-page: 26235 year: 2016 ident: bib1 article-title: Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases publication-title: Sci. Rep. – volume: 20 start-page: 231 year: 2010 end-page: 244 ident: bib9 article-title: The expanding range of parvoviruses which infect humans publication-title: Rev. Med. Virol. – volume: 75 start-page: 1145 year: 2009 end-page: 1152 ident: bib11 article-title: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy publication-title: Kidney Int. – volume: 124 start-page: 2299 year: 2014 end-page: 2306 ident: bib16 article-title: Cellular and molecular mechanisms in kidney fibrosis publication-title: J. Clin. Invest. – volume: 49 start-page: 44 year: 2012 end-page: 63 ident: bib55 article-title: Of mice and microflora: considerations for genetically engineered mice publication-title: Vet. Pathol. – volume: 31 start-page: 3406 year: 2003 end-page: 3415 ident: bib63 article-title: Mfold web server for nucleic acid folding and hybridization prediction publication-title: Nucleic Acids Res. – volume: 7 start-page: 13 year: 2010 end-page: 19 ident: bib60 article-title: Models of chronic kidney disease publication-title: Drug Discov. Today Dis. Models – volume: 65 start-page: 293 year: 1991 end-page: 304 ident: bib51 article-title: Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction publication-title: Cell – volume: 89 start-page: 792 year: 2016 end-page: 808 ident: bib15 article-title: Keratins are novel markers of renal epithelial cell injury publication-title: Kidney Int. – volume: 43 start-page: e47 year: 2015 ident: bib44 article-title: Limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. – volume: 56 start-page: 435 year: 2006 end-page: 438 ident: bib3 article-title: Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus) publication-title: Comp. Med. – volume: 17 start-page: 10 year: 2011 end-page: 12 ident: bib34 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal – volume: 28 start-page: 1420 year: 2012 end-page: 1428 ident: bib40 article-title: IDBA-UD: a de novo assembler for single-cell and metagenomic sequencing data with highly uneven depth publication-title: Bioinformatics – volume: 6 start-page: e17288 year: 2011 ident: bib50 article-title: Fast identification and removal of sequence contamination from genomic and metagenomic datasets publication-title: PloS ONE – volume: 18 start-page: 821 year: 2008 end-page: 829 ident: bib61 article-title: Velvet: algorithms for de novo short read assembly using de Bruijn graphs publication-title: Genome Res. – volume: 41 start-page: e108 year: 2013 ident: bib31 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. – volume: 165 start-page: 3284 year: 2000 end-page: 3292 ident: bib56 article-title: The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse publication-title: J. Immunol. – volume: 76 start-page: 17 year: 1994 end-page: 27 ident: bib24 article-title: T cell receptor antagonist peptides induce positive selection publication-title: Cell – volume: 28 start-page: 1086 year: 2012 end-page: 1092 ident: bib52 article-title: Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels publication-title: Bioinformatics – reference: Ashhurst, T.M. (2017). tSNEplots (University of Sydney). – volume: 389 start-page: 1238 year: 2016 end-page: 1252 ident: bib59 article-title: Chronic kidney disease publication-title: Lancet – volume: 5 start-page: R80 year: 2004 ident: bib18 article-title: Bioconductor: open software development for computational biology and bioinformatics publication-title: Genome Biol. – volume: 8 start-page: 1207 year: 2014 end-page: 1217 ident: bib22 article-title: The identification of three novel biomarkers of major adverse kidney events publication-title: Biomarkers Med. – volume: 45 start-page: 593 year: 2007 end-page: 605 ident: bib36 article-title: A global double-fluorescent Cre reporter mouse publication-title: Genesis – volume: 20 start-page: 1 year: 1992 end-page: 17 ident: bib38 article-title: Tubulointerstitial changes as a major determinant in the progression of renal damage publication-title: Am. J. Kidney Dis. – volume: 41 start-page: e108 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib31 article-title: The Subread aligner: fast, accurate and scalable read mapping by seed-and-vote publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkt214 – volume: 52 start-page: 696 year: 2003 ident: 10.1016/j.cell.2018.08.013_bib21 article-title: A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood publication-title: Syst. Biol. doi: 10.1080/10635150390235520 – volume: 12 start-page: 68 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib62 article-title: Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis publication-title: Nat. Rev. Nephrol. doi: 10.1038/nrneph.2015.215 – volume: 49 start-page: 277 year: 2008 ident: 10.1016/j.cell.2018.08.013_bib7 article-title: Lurking in the shadows: emerging rodent infectious diseases publication-title: ILAR J. doi: 10.1093/ilar.49.3.277 – volume: 17 start-page: 10 year: 2011 ident: 10.1016/j.cell.2018.08.013_bib34 article-title: Cutadapt removes adapter sequences from high-throughput sequencing reads publication-title: EMBnet.journal doi: 10.14806/ej.17.1.200 – volume: 30 start-page: 772 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib28 article-title: MAFFT multiple sequence alignment software version 7: improvements in performance and usability publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/mst010 – volume: 45 start-page: 593 year: 2007 ident: 10.1016/j.cell.2018.08.013_bib36 article-title: A global double-fluorescent Cre reporter mouse publication-title: Genesis doi: 10.1002/dvg.20335 – volume: 6 start-page: e17288 year: 2011 ident: 10.1016/j.cell.2018.08.013_bib50 article-title: Fast identification and removal of sequence contamination from genomic and metagenomic datasets publication-title: PloS ONE doi: 10.1371/journal.pone.0017288 – year: 2012 ident: 10.1016/j.cell.2018.08.013_bib29 – start-page: 623 year: 2007 ident: 10.1016/j.cell.2018.08.013_bib8 article-title: Spontaneous diseases in commonly used mouse strains A2 – volume: 159 start-page: 1239 year: 2014 ident: 10.1016/j.cell.2018.08.013_bib14 article-title: The family Parvoviridae publication-title: Arch. Virol. doi: 10.1007/s00705-013-1914-1 – volume: 25 start-page: 1972 year: 2009 ident: 10.1016/j.cell.2018.08.013_bib10 article-title: trimAl: a tool for automated alignment trimming in large-scale phylogenetic analyses publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp348 – volume: 76 start-page: 17 year: 1994 ident: 10.1016/j.cell.2018.08.013_bib24 article-title: T cell receptor antagonist peptides induce positive selection publication-title: Cell doi: 10.1016/0092-8674(94)90169-4 – volume: 120 start-page: 4065 year: 2010 ident: 10.1016/j.cell.2018.08.013_bib57 article-title: Lipocalin 2 is essential for chronic kidney disease progression in mice and humans publication-title: J. Clin. Invest. doi: 10.1172/JCI42004 – volume: 6 start-page: 26235 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib1 article-title: Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases publication-title: Sci. Rep. doi: 10.1038/srep26235 – ident: 10.1016/j.cell.2018.08.013_bib2 – volume: 171 start-page: 6556 year: 2003 ident: 10.1016/j.cell.2018.08.013_bib12 article-title: Reduced switching in SCID B cells is associated with altered somatic mutation of recombined S regions publication-title: J. Immunol. doi: 10.4049/jimmunol.171.12.6556 – volume: 9 start-page: 18 year: 1996 ident: 10.1016/j.cell.2018.08.013_bib17 article-title: Sequence-based identification of microbial pathogens: a reconsideration of Koch’s postulates publication-title: Clin. Microbiol. Rev. doi: 10.1128/CMR.9.1.18 – volume: 124 start-page: 2299 year: 2014 ident: 10.1016/j.cell.2018.08.013_bib16 article-title: Cellular and molecular mechanisms in kidney fibrosis publication-title: J. Clin. Invest. doi: 10.1172/JCI72267 – volume: 54 start-page: 855 year: 2017 ident: 10.1016/j.cell.2018.08.013_bib47 article-title: Pathology of Aging in NOD scid gamma Female Mice publication-title: Vet. Pathol. doi: 10.1177/0300985817698210 – volume: 305 start-page: F1391 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib27 article-title: Increased tubulointerstitial recruitment of human CD141(hi) CLEC9A(+) and CD1c(+) myeloid dendritic cell subsets in renal fibrosis and chronic kidney disease publication-title: Am. J. Physiol. Renal Physiol. doi: 10.1152/ajprenal.00318.2013 – volume: 7 start-page: 316ra193 year: 2015 ident: 10.1016/j.cell.2018.08.013_bib26 article-title: Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker publication-title: Sci. Transl. Med. doi: 10.1126/scitranslmed.aac7071 – volume: 5 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib13 article-title: Parvovirus diversity and DNA damage responses publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a012989 – volume: 29 start-page: 644 year: 2011 ident: 10.1016/j.cell.2018.08.013_bib20 article-title: Full-length transcriptome assembly from RNA-Seq data without a reference genome publication-title: Nat. Biotechnol. doi: 10.1038/nbt.1883 – volume: 28 start-page: 2432 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib6 article-title: Animal models of chronic kidney disease: useful but not perfect publication-title: Nephrol. Dial. Transplant. doi: 10.1093/ndt/gft071 – volume: 65 start-page: 293 year: 1991 ident: 10.1016/j.cell.2018.08.013_bib51 article-title: Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction publication-title: Cell doi: 10.1016/0092-8674(91)90163-S – volume: 15 start-page: 1181 year: 2014 ident: 10.1016/j.cell.2018.08.013_bib5 article-title: High-dimensional analysis of the murine myeloid cell system publication-title: Nat. Immunol. doi: 10.1038/ni.3006 – volume: 2 start-page: 84 year: 2015 ident: 10.1016/j.cell.2018.08.013_bib35 article-title: Intranuclear inclusions in renal tubular epithelium in immunodeficient mice stain with antibodies for bovine papillomavirus type 1 L1 protein publication-title: Vet. Sci. doi: 10.3390/vetsci2020084 – volume: 369 start-page: 84 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib25 article-title: One step closer to “Rejectostix” publication-title: N. Engl. J. Med. doi: 10.1056/NEJMe1307013 – volume: 44 start-page: D447 issue: D1 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib58 article-title: 2016 update of the PRIDE database and its related tools publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv1145 – volume: 89 start-page: 792 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib15 article-title: Keratins are novel markers of renal epithelial cell injury publication-title: Kidney Int. doi: 10.1016/j.kint.2015.10.015 – volume: 31 start-page: 3406 year: 2003 ident: 10.1016/j.cell.2018.08.013_bib63 article-title: Mfold web server for nucleic acid folding and hybridization prediction publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkg595 – volume: 214 start-page: 110 year: 2001 ident: 10.1016/j.cell.2018.08.013_bib49 article-title: Observation of antigen-dependent CD8+ T-cell/ dendritic cell interactions in vivo publication-title: Cell. Immunol. doi: 10.1006/cimm.2001.1895 – volume: 7 start-page: 13 year: 2010 ident: 10.1016/j.cell.2018.08.013_bib60 article-title: Models of chronic kidney disease publication-title: Drug Discov. Today Dis. Models doi: 10.1016/j.ddmod.2010.08.002 – volume: 33 start-page: 290 year: 2015 ident: 10.1016/j.cell.2018.08.013_bib41 article-title: StringTie enables improved reconstruction of a transcriptome from RNA-seq reads publication-title: Nat. Biotechnol. doi: 10.1038/nbt.3122 – volume: 56 start-page: 435 year: 2006 ident: 10.1016/j.cell.2018.08.013_bib3 article-title: Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus) publication-title: Comp. Med. – volume: 75 start-page: 1145 year: 2009 ident: 10.1016/j.cell.2018.08.013_bib11 article-title: Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy publication-title: Kidney Int. doi: 10.1038/ki.2009.86 – volume: 14 start-page: 564 year: 2013 ident: 10.1016/j.cell.2018.08.013_bib45 article-title: Cutaneous immunosurveillance and regulation of inflammation by group 2 innate lymphoid cells publication-title: Nat. Immunol. doi: 10.1038/ni.2584 – volume: 18 start-page: 821 year: 2008 ident: 10.1016/j.cell.2018.08.013_bib61 article-title: Velvet: algorithms for de novo short read assembly using de Bruijn graphs publication-title: Genome Res. doi: 10.1101/gr.074492.107 – volume: 20 start-page: 1 year: 1992 ident: 10.1016/j.cell.2018.08.013_bib38 article-title: Tubulointerstitial changes as a major determinant in the progression of renal damage publication-title: Am. J. Kidney Dis. doi: 10.1016/S0272-6386(12)80312-X – volume: 28 start-page: 1420 year: 2012 ident: 10.1016/j.cell.2018.08.013_bib40 article-title: IDBA-UD: a de novo assembler for single-cell and metagenomic sequencing data with highly uneven depth publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts174 – volume: 28 start-page: 1086 year: 2012 ident: 10.1016/j.cell.2018.08.013_bib52 article-title: Oases: robust de novo RNA-seq assembly across the dynamic range of expression levels publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts094 – year: 2016 ident: 10.1016/j.cell.2018.08.013_bib4 – volume: 26 start-page: 589 year: 2010 ident: 10.1016/j.cell.2018.08.013_bib30 article-title: Fast and accurate long-read alignment with Burrows-Wheeler transform publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp698 – volume: 5 start-page: S24 issue: Suppl 1 year: 2012 ident: 10.1016/j.cell.2018.08.013_bib32 article-title: CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis publication-title: Fibrogenesis Tissue Repair doi: 10.1186/1755-1536-5-S1-S24 – volume: 43 start-page: e47 year: 2015 ident: 10.1016/j.cell.2018.08.013_bib44 article-title: Limma powers differential expression analyses for RNA-sequencing and microarray studies publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv007 – volume: 25 start-page: 1105 year: 2009 ident: 10.1016/j.cell.2018.08.013_bib54 article-title: TopHat: discovering splice junctions with RNA-Seq publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp120 – volume: 13 start-page: 104 year: 2017 ident: 10.1016/j.cell.2018.08.013_bib19 article-title: The global burden of chronic kidney disease: estimates, variability and pitfalls publication-title: Nat. Rev. Nephrol. doi: 10.1038/nrneph.2016.163 – volume: 132 start-page: 487 year: 2008 ident: 10.1016/j.cell.2018.08.013_bib46 article-title: Visualizing spatiotemporal dynamics of multicellular cell-cycle progression publication-title: Cell doi: 10.1016/j.cell.2007.12.033 – volume: 2 start-page: 631 year: 2006 ident: 10.1016/j.cell.2018.08.013_bib33 article-title: Primer: histopathology of polyomavirus-associated nephropathy in renal allografts publication-title: Nat. Clin. Pract. Nephrol. doi: 10.1038/ncpneph0319 – volume: 14 start-page: 693 year: 2015 ident: 10.1016/j.cell.2018.08.013_bib37 article-title: Dissecting fibrosis: therapeutic insights from the small-molecule toolbox publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd4592 – volume: 165 start-page: 3284 year: 2000 ident: 10.1016/j.cell.2018.08.013_bib56 article-title: The primate lentiviral receptor Bonzo/STRL33 is coordinately regulated with CCR5 and its expression pattern is conserved between human and mouse publication-title: J. Immunol. doi: 10.4049/jimmunol.165.6.3284 – volume: 389 start-page: 1238 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib59 article-title: Chronic kidney disease publication-title: Lancet doi: 10.1016/S0140-6736(16)32064-5 – volume: 342 start-page: 559 year: 1989 ident: 10.1016/j.cell.2018.08.013_bib42 article-title: Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen publication-title: Nature doi: 10.1038/342559a0 – volume: 2016 start-page: 1319578 year: 2016 ident: 10.1016/j.cell.2018.08.013_bib48 article-title: Expression of CD24 in human bone marrow-derived mesenchymal stromal cells is regulated by TGFβ3 and induces a myofibroblast-like genotype publication-title: Stem Cells Int. doi: 10.1155/2016/1319578 – volume: 8 start-page: 1207 year: 2014 ident: 10.1016/j.cell.2018.08.013_bib22 article-title: The identification of three novel biomarkers of major adverse kidney events publication-title: Biomarkers Med. doi: 10.2217/bmm.14.90 – volume: 62 start-page: 237 year: 2002 ident: 10.1016/j.cell.2018.08.013_bib23 article-title: Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury publication-title: Kidney Int. doi: 10.1046/j.1523-1755.2002.00433.x – volume: 49 start-page: 44 year: 2012 ident: 10.1016/j.cell.2018.08.013_bib55 article-title: Of mice and microflora: considerations for genetically engineered mice publication-title: Vet. Pathol. doi: 10.1177/0300985811431446 – volume: 98 start-page: 225 year: 2017 ident: 10.1016/j.cell.2018.08.013_bib53 article-title: Chapparvoviruses occur in at least three vertebrate classes and have a broad biogeographic distribution publication-title: J. Gen. Virol. doi: 10.1099/jgv.0.000671 – volume: 5 start-page: R80 year: 2004 ident: 10.1016/j.cell.2018.08.013_bib18 article-title: Bioconductor: open software development for computational biology and bioinformatics publication-title: Genome Biol. doi: 10.1186/gb-2004-5-10-r80 – volume: 400 start-page: 110 year: 2010 ident: 10.1016/j.cell.2018.08.013_bib39 article-title: Comparison of methods in the recovery of nucleic acids from archival formalin-fixed paraffin-embedded autopsy tissues publication-title: Anal. Biochem. doi: 10.1016/j.ab.2010.01.014 – volume: 20 start-page: 231 year: 2010 ident: 10.1016/j.cell.2018.08.013_bib9 article-title: The expanding range of parvoviruses which infect humans publication-title: Rev. Med. Virol. doi: 10.1002/rmv.648 – volume: 87 start-page: 621 year: 2009 ident: 10.1016/j.cell.2018.08.013_bib43 article-title: The decade of polyomavirus BK-associated nephropathy: state of affairs publication-title: Transplantation doi: 10.1097/TP.0b013e318197c17d – reference: 30262845 - Nat Rev Nephrol. 2018 Dec;14(12):719 – reference: 30290137 - Cell. 2018 Oct 4;175(2):310-311 |
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| SubjectTerms | adaptive immunity Animals Australia chronic kidney disease disease course Disease Progression Female fibrosis Fibrosis - pathology Fibrosis - virology histopathology Humans inclusion body nephropathy Kidney - metabolism Kidney - physiology kidneys Male metagenomics Mice Mice, Inbred C57BL Nephritis, Interstitial - physiopathology Nephritis, Interstitial - virology North America Parvoviridae Parvoviridae Infections - metabolism parvovirus Parvovirus - isolation & purification Parvovirus - pathogenicity pathogens Protoparvovirus renal failure tubulointerstitial fibrosis viral metagenomics viruses |
| Title | An Atypical Parvovirus Drives Chronic Tubulointerstitial Nephropathy and Kidney Fibrosis |
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