Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7 - Ismail, Hanafy M.; Barton, Victoria; Phanchana, Matthew; Charoensutthivarakul, Sitthivut; Wong, Michael H. L.; Hemingway, Janet; Biagini, Giancarlo A.; O’Neill, Paul M.; Ward, Stephen A. (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: Antimalarials - chemical synthesis; Antimalarials - chemistry; Antimalarials - pharmacology; Antioxidants; Artemisinins - chemical synthesis; Artemisinins - chemistry; Artemisinins - pharmacology; Biological Sciences; Chromatography; Click Chemistry; Hemoglobin; Humans; Lactones - chemical synthesis; Lactones - chemistry; Lactones - pharmacology; Life Cycle Stages - drug effects; Liquid chromatography; Malaria; Molecular Probes - chemical synthesis; Molecular Probes - chemistry; Molecular Probes - pharmacology; Parasites; Plasmodium falciparum; Plasmodium falciparum - metabolism; Probes; Protein synthesis; Protozoan Proteins - antagonists & inhibitors; Protozoan Proteins - metabolism; Vector-borne diseases; artemisinin; chemical proteomics; antimalarial; molecular targets; bioactivation