Identifying the Best Marker Combination in CEA, CA125, CY211, NSE, and SCC for Lung Cancer Screening by Combining ROC Curve and Logistic Regression Analyses: Is It Feasible?

• Published in: Disease markers Vol. 2018; no. 2018; pp. 1 - 12
• Main Authors: Lu, Kefeng, Wu, Rongqiang, Zhang, Ping, Yang, Qixian, Zhou, Hongxing
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc
• Subjects: Aged; Analyzers; Antigens; Antigens, Neoplasm - blood; Bacterial pneumonia; Biomarkers; CA-125 Antigen - blood; Cancer; Cancer screening; Carbohydrates; Carcinoembryonic antigen; Carcinoembryonic Antigen - blood; Case-Control Studies; CEA (Oncology); Chemiluminescence; Cytokeratin; Diagnosis; Diagnostic systems; Feasibility Studies; Female; Health aspects; Humans; Keratin-19 - blood; Logistic Models; Lung cancer; Lung Neoplasms - blood; Male; Medical prognosis; Medical research; Medical screening; Membrane Proteins - blood; Methods; Middle Aged; Organic chemistry; Ovarian cancer; Patients; Phosphopyruvate hydratase; Phosphopyruvate Hydratase - blood; Pneumonia; Regression analysis; ROC Curve; Serpins - blood; Squamous cell carcinoma; Studies; Tumors; Women

The detection of serum biomarkers can aid in the diagnosis of lung cancer. In recent years, an increasing number of lung cancer markers have been identified, and these markers have been reported to have varying diagnostic values. A method to compare the diagnostic value of different combinations of...