The effect of degradable polymer surfaces on co-cultures of monocytes and smooth muscle cells

• Published in: Biomaterials Vol. 32; no. 14; pp. 3584 - 3595
• Main Authors: McBane, Joanne E, Battiston, Kyle G, Wadhwani, Aman, Sharifpoor, Soroor, Labow, Rosalind S, Santerre, J. Paul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2011
• Subjects: Advanced Basic Science; Biocompatible Materials - pharmacology; Biomaterials; Biomedical materials; Cells, Cultured; Coculture Techniques; Degradation; Dentistry; Enzyme-Linked Immunosorbent Assay; Human; Humans; Immunoblotting; Markers; Microscopy, Electron, Scanning; Monocyte; Monocytes - drug effects; Monocytes - metabolism; Monocytes - ultrastructure; Muscles; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - ultrastructure; Photoelectron Spectroscopy; Poly-lactic-glycolic acid; Polymers - pharmacology; Polyurethane; Surface chemistry; Surgical implants; TCP (protocol); Vascular smooth muscle cells; Monocyte; Poly-lactic-glycolic acid; Polyurethane; Vascular smooth muscle cells; Surface chemistry

Abstract Strategies to optimize biomaterial chemistry for applications in vascular tissue engineering attempt to promote endothelial and smooth muscle cell recruitment into porous material constructs. The primary objective is to facilitate relevant tissue formation in a wound healing versus pro-infl...