Dose Optimization of Colistin: A Systematic Review

• Published in: Antibiotics (Basel) Vol. 10; no. 12; p. 1454
• Main Authors: Haseeb, Abdul, Faidah, Hani Saleh, Alghamdi, Saleh, Alotaibi, Amal F., Elrggal, Mahmoud Essam, Mahrous, Ahmad Jamal, Almarzoky Abuhussain, Safa S., Obaid, Najla A., Algethamy, Manal, AlQarni, Abdullmoin, Khogeer, Asim A., Saleem, Zikria, Sheikh, Aziz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 26.11.2021; MDPI
• Subjects: Antibiotics; Bacterial diseases; Bacterial infections; Case reports; Clinical outcomes; Clinical trials; Colistin; Data search; Dosage; dose optimization; Drug dosages; Drug resistance; Gram-negative bacteria; Gram-negative infections; Infections; Maintenance; nephrotoxicity; Optimization; Patients; Pediatrics; Pharmacokinetics; Plasma; Regulatory approval; Reviews; Systematic Review; dose optimization; nephrotoxicity; Gram-negative infections; colistin

Colistin is considered a last treatment option for multi-drug and extensively resistant Gram-negative infections. We aimed to assess the available data on the dosing strategy of colistin. A systematic review was performed to identify all published studies on the dose optimization of colistin. Grey l...