Cancer-specific glycosylation of CD13 impacts its detection and activity in preclinical cancer tissues

• Published in: iScience Vol. 26; no. 11; p. 108219
• Main Authors: Barnieh, Francis M., Galuska, Sebastian P., Loadman, Paul M., Ward, Simon, Falconer, Robert A., El-Khamisy, Sherif F.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 17.11.2023; Elsevier
• Subjects: Cancer; Glycobiology; Molecular biology; Molecular biology; Glycobiology; Cancer

Harnessing the differences between cancer and non-cancer tissues presents new opportunities for selective targeting by anti-cancer drugs. CD13, a heavily glycosylated protein, is one example with significant unmet clinical potential in cancer drug discovery. Despite its high expression and activity...