Oxidative Stress and Gut-Derived Lipopolysaccharides in Neurodegenerative Disease: Role of NOX2

• Published in: Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 7
• Main Authors: Pigozzi, Fabio, Cacciafesta, Mauro, Violi, Francesco, Carnevale, Roberto, Wenzel, Philip, Fossati, Chiara, Spalice, Alberto, Perri, Ludovica, Nocella, Cristina, Inghilleri, Maurizio, Zicari, Anna Maria, Ettorre, Evaristo, Loffredo, Lorenzo, De Lucia, Maria C.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Activities of daily living; Age; Aged; Alzheimer's disease; Amyotrophic lateral sclerosis; Analysis; Blood pressure; Cholesterol; Disease; Female; Humans; Inflammation; Internal medicine; Lipopolysaccharides - metabolism; Male; Microbiota; Microbiota (Symbiotic organisms); Mitogens; NADPH Oxidase 2 - metabolism; Nervous system; Nervous system diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - physiopathology; Oxidases; Oxidative Stress; Parkinson's disease; Peptides; Smoking; Stress analysis; Variance analysis

Background. Neurodegenerative diseases (ND) as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis represent a growing cause of disability in the developed countries. The underlying physiopathology is still unclear. Several lines of evidence suggest a role for oxidative stres...