Neuropathological approaches to cerebral aging and neuroplasticity

• Published in: Dialogues in clinical neuroscience Vol. 15; no. 1; pp. 29 - 43
• Main Authors: Jellinger, Kurt A., Attems, Johannes
• Format: Journal Article
• Language: English
• Published: Neuilly-sur-Seine Taylor & Francis 31.03.2013; Servier; Les Laboratoires Servier
• Subjects: Adult. Elderly; Aged; Aged, 80 and over; Aging - pathology; Aging - physiology; Alzheimer Disease - complications; Alzheimer Disease - pathology; Amyloid beta-Peptides - metabolism; Biological and medical sciences; brain aging; Cerebral Cortex - pathology; Cognition Disorders - etiology; Cognition Disorders - pathology; cognitive reserve; Developmental psychology; DNA-Binding Proteins - metabolism; Female; Fundamental and applied biological sciences. Psychology; Humans; Male; molecular mechanism; neurogenesis; Neuronal Plasticity - physiology; neuropathology; neuroplasticity; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; structural and functional base; Translational Research; Human; Cognitive reserve; Senescence; Central nervous system; brain aging; Cognition; Review; Neurogenesis; Encephalon; structural and functional base; Anatomic pathology; Brain plasticity; molecular mechanism; neuropathology; neuroplasticity; cognitive reserve; neurogenesis

Cerebral aging is a complex and heterogenous process related to a large variety of molecular changes involving multiple neuronal networks, due to alterations of neurons (synapses, axons, dendrites, etc), particularly affecting strategically important regions, such as hippocampus and prefrontal areas...