Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans

• Published in: The FASEB journal Vol. 15; no. 7; p. 1181
• Main Authors: Møller, P, Loft, S, Lundby, C, Olsen, N V
• Format: Journal Article
• Language: English
• Published: United States 01.05.2001
• Subjects: Adult; Altitude; Comet Assay; Deoxyguanosine - analogs & derivatives; Deoxyguanosine - urine; Deoxyribonuclease (Pyrimidine Dimer); DNA Damage - genetics; DNA Damage - physiology; DNA Repair - genetics; DNA Repair - physiology; DNA-Formamidopyrimidine Glycosylase; Endodeoxyribonucleases - metabolism; Escherichia coli Proteins; Exercise; Exercise Test; Female; Humans; Hypoxia; Lymphocytes - physiology; Male; N-Glycosyl Hydrolases - metabolism; Oxygen - physiology; Oxygen Consumption

The present study investigated the effect of a single bout of exhaustive exercise on the generation of DNA strand breaks and oxidative DNA damage under normal conditions and at high-altitude hypoxia (4559 meters for 3 days). Twelve healthy subjects performed a maximal bicycle exercise test; lymphocy...