Augmenting workload drives T‐tubule assembly in developing cardiomyocytes

• Published in: The Journal of physiology Vol. 602; no. 18; pp. 4461 - 4486
• Main Authors: Manfra, Ornella, Louey, Samantha, Jonker, Sonnet S., Perdreau‐Dahl, Harmonie, Frisk, Michael, Giraud, George D., Thornburg, Kent L., Louch, William E.
• Format: Journal Article
• Language: English; Norwegian
• Published: England Wiley Subscription Services, Inc 01.09.2024; Wiley
• Subjects: Angiotensin; Angiotensin-converting enzyme inhibitors; Aorta; Blood pressure; Calcium (blood); Calcium (reticular); Calcium channels; Cardiac muscle; Cardiology and cardiovascular system; Cardiomyocytes; Coronary vessels; Dynamin; fetal development; Fetuses; Gestational age; Human health and pathology; Hypertrophy; Life Sciences; Maturation; Na+/Ca2+ exchanger; Peptidyl-dipeptidase A; Proteins; Regulatory proteins; Ryanodine receptors; Sarcoplasmic reticulum; Sheep; Tubules; t‐tubule; workload; Workloads; cardiomyocytes; workload; ryanodine receptors; t‐tubule; fetal development; t-tubule

Contraction of cardiomyocytes is initiated at subcellular elements called dyads, where L‐type Ca2+ channels in t‐tubules are located within close proximity to ryanodine receptors in the sarcoplasmic reticulum. While evidence from small rodents indicates that dyads are assembled gradually in the deve...