Cryptolepis sanguinolenta: an ethnobotanical approach to drug discovery and the isolation of a potentially useful new antihyperglycaemic agent

• Published in: Diabetic medicine Vol. 15; no. 5; pp. 367 - 374
• Main Authors: Luo, J., Fort, D.M., Carlson, T.J., Noamesi, B.K., nii-Amon-Kotei, D., King, S.R., Tsai, J., Quan, J., Hobensack, C., Lapresca, P., Waldeck, N., Mendez, C.D., Jolad, S.D., Bierer, D.E., Reaven, G.M.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.05.1998; Blackwell
• Subjects: Adipose Tissue - cytology; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Aged; Alkaloids - isolation & purification; Alkaloids - pharmacology; Alkaloids - therapeutic use; Animals; antihyperglycaemic agents; Biological and medical sciences; Blood Glucose - drug effects; Blood Glucose - metabolism; Cell Line; Cryptolepis sanguinolenta; Diabetes Mellitus, Type 2 - drug therapy; drug discovery; Drug Evaluation, Preclinical; Ethics, Pharmacy; ethnobotany; ethnomedicine; General pharmacology; Glucose - pharmacokinetics; Humans; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - isolation & purification; Hypoglycemic Agents - pharmacology; Indole Alkaloids; Indoles; Insulin - blood; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Obese; Middle Aged; Miscellaneous; Pharmacology. Drug treatments; Plants, Medicinal - chemistry; Quinolines; Type 2 diabetes mellitus; Vasodilator Agents - isolation & purification; Vasodilator Agents - pharmacology; Vasodilator Agents - therapeutic use; United States; North America; America; Endocrinopathy; Human; Ethnobotany; Treatment efficiency; Rodentia; Asclepiadaceae; Non insulin dependent diabetes; Medicinal plant; Vertebrata; Alkaloid; Chemotherapy; Hypoglycemic agent; Mammalia; Treatment; Mouse; Dicotyledones; Animal; Angiospermae; Spermatophyta; Glycemia

Evidence has been published that a wide array of plant‐derived active principles, representing numerous classes of chemical compounds, demonstrate activity consistent with their possible use in the treatment of patients with Type 2 diabetes mellitus (DM). Despite these interesting observations, to d...