Salivary metabolomic biomarkers for esophageal and gastric cancers by liquid chromatography–mass spectrometry

• Published in: Cancer Science Vol. 115; no. 9; pp. 3089 - 3098
• Main Authors: Nakane, Kosuke, Yagi, Koichi, Yajima, Sho, Nomura, Sachiyo, Sugimoto, Masahiro, Seto, Yasuyuki
• Format: Journal Article
• Language: English
• Published: England Wiley 01.09.2024; John Wiley & Sons, Inc; John Wiley and Sons Inc
• Subjects: Adult; Aged; Antigens; Biomarkers; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Chemotherapy; Chromatography; Chromatography, Liquid - methods; Cost analysis; Cytosine; Early Detection of Cancer - methods; Endoscopy; Esophageal cancer; Esophageal Neoplasms - diagnosis; Esophageal Neoplasms - metabolism; Esophagus; Female; Gastric cancer; Humans; Laboratories; LC‐MS; Liquid chromatography; Liquid Chromatography-Mass Spectrometry; Male; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; Metabolism; Metabolites; metabolome; Metabolomics; Metabolomics - methods; Middle Aged; Original; ORIGINAL ARTICLE; Radiation therapy; Saliva; Saliva - chemistry; Saliva - metabolism; Scientific imaging; Sensitivity and Specificity; Stomach Neoplasms - diagnosis; Stomach Neoplasms - metabolism; Surgery; Tumor markers; Tumors; saliva; LC‐MS; esophageal cancer; gastric cancer; metabolome

Early detection of esophageal and gastric cancers is essential for patients' prognosis; however, optimal noninvasive screening tests are currently not available. Saliva is a biofluid that is readily available, allowing for frequent screening tests. Thus, we explored salivary diagnostic biomarke...