Common Genetic Variation of the Low‐Density Lipoprotein Receptor‐Related Protein 5 and 6 Genes Determines Fracture Risk in Elderly White Men

• Published in: Journal of bone and mineral research Vol. 21; no. 1; pp. 141 - 150
• Main Authors: van Meurs, Joyce BJ, Rivadeneira, Fernando, Jhamai, Mila, Hugens, Wendy, Hofman, Albert, van Leeuwen, Johannes PTM, Pols, Huibert AP, Uitterlinden, André G
• Format: Journal Article
• Language: English
• Published: Washington, DC John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 01.01.2006; American Society for Bone and Mineral Research
• Subjects: Aged; Aged, 80 and over; Amino Acid Substitution; Biological and medical sciences; Bone Density - genetics; Cohort Studies; European Continental Ancestry Group; Female; Fractures, Bone - genetics; Fundamental and applied biological sciences. Psychology; genetic association; Humans; LDL-Receptor Related Proteins - genetics; Linkage Disequilibrium; Low Density Lipoprotein Receptor-Related Protein-5; Low Density Lipoprotein Receptor-Related Protein-6; Male; Middle Aged; osteoporosis; Osteoporosis - genetics; polymorphism; Polymorphism, Genetic; Risk Factors; Sex Factors; Skeleton and joints; Vertebrates: osteoarticular system, musculoskeletal system; Human; Diseases of the osteoarticular system; genetic association; Fracture; Trauma; Protein; Lipoprotein LDL; Osteoarticular system; Osteoporosis; Vertebrata; Mammalia; Gene; low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 5; Genetics; Elderly; Polymorphism; Biological receptor

Both LRP5 and LRP6 genes have been implicated to play a role in bone metabolism. In a large population‐based study, we related common variation in both genes to bone parameters and fractures. LRP5 variation was associated to both BMD and frame size, whereas both LRP5 and 6 variations were associated...