Second-order spatial analysis of epidermal nerve fibers

• Published in: Statistics in medicine Vol. 30; no. 23; pp. 2827 - 2841
• Main Authors: Waller, Lance A., Särkkä, Aila, Olsbo, Viktor, Myllymäki, Mari, Panoutsopoulou, Ioanna G., Kennedy, William R., Wendelschafer-Crabb, Gwen
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 15.10.2011; Wiley Subscription Services, Inc
• Subjects: cells; Computer Simulation; Data Interpretation, Statistical; Diabetic Neuropathies - pathology; Diabetic neuropathy; Humans; K function; Microscopy, Confocal; Monte Carlo Method; Nerve Fibers - pathology; Nerve Fibers - ultrastructure; Neurology; Neurons; pair-correlation function; Physiology; point patterns; Probability Theory and Statistics; Sannolikhetsteori och statistik; Skin; Skin - innervation; Skin - ultrastructure; skin blister; spatial point/fiber processes

Breakthroughs in imaging of skin tissue reveal new details on the distribution of nerve fibers in the epidermis. Preliminary neurologic studies indicate qualitative differences in the spatial patterns of nerve fibers based on pathophysiologic conditions in the subjects. Of particular interest is the...