Regulation of Lipolysis in Small and Large Fat Cells of the Same Subject

• Published in: The journal of clinical endocrinology and metabolism Vol. 96; no. 12; pp. E2045 - E2049
• Main Authors: Laurencikiene, Jurga, Skurk, Thomas, Kulyté, Agné, Hedén, Per, Åström, Gaby, Sjölin, Eva, Rydén, Mikael, Hauner, Hans, Arner, Peter
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.12.2011; Copyright by The Endocrine Society
• Subjects: Adipocytes; Adipocytes - drug effects; Adipocytes - physiology; Adipose tissue; Adult; Aged; Atrial Natriuretic Factor - pharmacology; Catecholamines; Cell Size; Diabetes; Diabetes mellitus (non-insulin dependent); Hormones; Humans; Hypertrophy; Insulin - pharmacology; Lipase; Lipolysis; Lipolysis - drug effects; Lipolysis - physiology; Middle Aged; Norepinephrine - pharmacology; Proteins; Regulatory proteins

Context:Large fat cell size is linked to type 2 diabetes risk and may involve an enhanced rate of adipocyte lipolysis causing elevated levels of fatty acids.Objective:Our objective was to study the role of fat cell size in the regulation of lipolysis within a subject.Design and Main Outcome Measures...