Once‐a‐Day Controlled‐Release Dosage form of Divalproex Sodium I: Formulation Design and in Vitro/in Vivo Investigations - Qiu, Yihong; Cheskin, Howard S.; Engh, Kevin R.; Poska, Richard P. (Journal of pharmaceutical sciences, 2003)
Keywords: Animals; Anticonvulsants - administration & dosage; Anticonvulsants - blood; Anticonvulsants - pharmacokinetics; Anticonvulsants. Antiepileptics. Antiparkinson agents; Biological and medical sciences; Chemistry, Pharmaceutical; controlled release; Cross-Over Studies; Delayed-Action Preparations; divalproex sodium; Dogs; Drug Administration Schedule; Drug Compounding; Excipients; Humans; in vitro release; In Vitro Techniques; in vitro-in vivo relationship; in vivo absorption; Intestinal Absorption; matrix system; Medical sciences; Methylcellulose; Neuropharmacology; Pharmacology. Drug treatments; Tablets; Time Factors; Valproic Acid - administration & dosage; Valproic Acid - blood; Valproic Acid - pharmacokinetics; controlled release; in vitro–in vivo relationship; divalproex sodium; in vitro release; in vivo absorption; matrix system; Anticonvulsant; Multiple dose; Absorption; Single daily dose; Tablet; Dog; Release; Human; Fissipedia; Carnivora; Pharmaceutical technology; Controlled release form; Single dose; Oral administration; Valproic acid; In vitro; In vivo; Vertebrata; Mammalia; Dosage form; Active ingredient; Pharmacokinetics; in vitro-in vivo relationship