Continuous determination of optimal cerebral perfusion pressure in traumatic brain injury

• Published in: Critical care medicine Vol. 40; no. 8; p. 2456
• Main Authors: Aries, Marcel J H, Czosnyka, Marek, Budohoski, Karol P, Steiner, Luzius A, Lavinio, Andrea, Kolias, Angelos G, Hutchinson, Peter J, Brady, Ken M, Menon, David K, Pickard, John D, Smielewski, Peter
• Format: Journal Article
• Language: English
• Published: United States 01.08.2012
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure - physiology; Brain Injuries - physiopathology; Cerebrovascular Circulation - physiology; Female; Humans; Intracranial Pressure - physiology; Male; Middle Aged; Monitoring, Physiologic; Retrospective Studies; Time Factors; Treatment Outcome; Young Adult

We have sought to develop an automated methodology for the continuous updating of optimal cerebral perfusion pressure (CPPopt) for patients after severe traumatic head injury, using continuous monitoring of cerebrovascular pressure reactivity. We then validated the CPPopt algorithm by determining th...