Costimulation of T‐cell proliferation by anti‐l‐selectin antibody is associated with the reduction of a cdk inhibitor p27

• Published in: Immunology Vol. 116; no. 3; pp. 347 - 353
• Main Authors: Nishijima, Ken‐ichi, Ando, Munetoshi, Sano, Shusuke, Hayashi‐Ozawa, Aiko, Kinoshita, Yoshinori, Iijima, Shinji
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.11.2005; Wiley Subscription Services, Inc; Blackwell Science Inc
• Subjects: Animals; Antibodies, Monoclonal - immunology; cdk inhibitor; Cell Proliferation; costimulation; Cyclin-Dependent Kinase Inhibitor p27 - metabolism; Extracellular Signal-Regulated MAP Kinases - metabolism; Interleukin-2 - metabolism; L-Selectin - immunology; Lymph Nodes - immunology; Lymphocyte Activation - immunology; l‐selectin; Male; Mice; Mice, Inbred BALB C; Original; p27; Reverse Transcriptase Polymerase Chain Reaction - methods; Superantigens - immunology; T-Lymphocytes - immunology; T‐cell proliferation

Summary In this study, we investigated the costimulatory activity of l‐selectin in primary mouse T cells. Proliferation induced by immobilized anti‐CD3 antibody was enhanced by immobilized anti‐l‐selectin antibody. In contrast to the anti‐CD28 antibody, anti‐l‐selectin antibody did not enhance inter...