Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy - Kim, Seo Rin; Puranik, Amrutesh S.; Jiang, Kai; Chen, Xiaojun; Zhu, Xiang-Yang; Taylor, Ian; Khodadadi-Jamayran, Alireza; Lerman, Amir; Hickson, LaTonya J.; Childs, Bennett G.; Textor, Stephen C.; Tchkonia, Tamara; et al. (Journal of the American Society of Nephrology, 2021)
Keywords: Animals; Apoptosis - drug effects; Basic Research; Caspase 8 - metabolism; Cellular Senescence - drug effects; Cellular Senescence - genetics; Cellular Senescence - physiology; Chronic Disease; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Cyclin-Dependent Kinase Inhibitor p19 - metabolism; Cyclin-Dependent Kinase Inhibitor p21 - genetics; Dasatinib - pharmacology; Disease Models, Animal; Enzyme Activation - drug effects; Epithelial Cells - physiology; Epithelial-Mesenchymal Transition; Gene Expression; Heparin-binding EGF-like Growth Factor - genetics; Humans; Ischemia - etiology; Ischemia - physiopathology; Kidney - blood supply; Kidney - pathology; Kidney - physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Osteopontin - genetics; p21-Activated Kinases - genetics; p21-Activated Kinases - metabolism; Protein Kinase Inhibitors - pharmacology; Renal Artery Obstruction - complications; Renal Insufficiency, Chronic - etiology; Renal Insufficiency, Chronic - pathology; Renal Insufficiency, Chronic - physiopathology; Sequence Analysis, RNA; Single-Cell Analysis; Tacrolimus - analogs & derivatives; Tacrolimus - pharmacology; Up-Regulation; senescence; quercetin; renal artery stenosis; dasatinib; transcriptome