Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat
ABSTRACT Bone marrow‐derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to th...
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| Published in | Wound repair and regeneration Vol. 14; no. 4; pp. 471 - 478 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Malden, USA
Blackwell Publishing Inc
01.07.2006
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| Subjects | |
| Online Access | Get full text |
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| Abstract | ABSTRACT
Bone marrow‐derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to the repair of injured tissues. Because of the extraordinary plasticity and the ability of syngeneic or allogeneic BMSCs to secrete tissue‐repair factors, we investigated the therapeutic efficacy of BMSCs for healing of fascial and cutaneous incisional wounds in Sprague–Dawley rats. Systemic administration of syngeneic BMSCs (2 × 106) once daily for 4 days or a single treatment with 5 × 106 BMSCs 24 hours after wounding significantly increased the wound bursting strength of fascial and cutaneous wounds on days 7 and 14 postwounding. Wound healing was also significantly improved following injection of BMSCs locally at the wound site. Furthermore, allogeneic BMSCs were as efficient as syngeneic BMSCs in promoting wound healing. Administration of BMSCs labeled with iron oxides/1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate fluorescent dye revealed that systemically administered BMSCs engraft to the wound. The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound. In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds. |
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| AbstractList | ABSTRACT
Bone marrow‐derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to the repair of injured tissues. Because of the extraordinary plasticity and the ability of syngeneic or allogeneic BMSCs to secrete tissue‐repair factors, we investigated the therapeutic efficacy of BMSCs for healing of fascial and cutaneous incisional wounds in Sprague–Dawley rats. Systemic administration of syngeneic BMSCs (2 × 106) once daily for 4 days or a single treatment with 5 × 106 BMSCs 24 hours after wounding significantly increased the wound bursting strength of fascial and cutaneous wounds on days 7 and 14 postwounding. Wound healing was also significantly improved following injection of BMSCs locally at the wound site. Furthermore, allogeneic BMSCs were as efficient as syngeneic BMSCs in promoting wound healing. Administration of BMSCs labeled with iron oxides/1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate fluorescent dye revealed that systemically administered BMSCs engraft to the wound. The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound. In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds. Bone marrow-derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to the repair of injured tissues. Because of the extraordinary plasticity and the ability of syngeneic or allogeneic BMSCs to secrete tissue-repair factors, we investigated the therapeutic efficacy of BMSCs for healing of fascial and cutaneous incisional wounds in Sprague-Dawley rats. Systemic administration of syngeneic BMSCs (2 x 10(6)) once daily for 4 days or a single treatment with 5 x 10(6) BMSCs 24 hours after wounding significantly increased the wound bursting strength of fascial and cutaneous wounds on days 7 and 14 postwounding. Wound healing was also significantly improved following injection of BMSCs locally at the wound site. Furthermore, allogeneic BMSCs were as efficient as syngeneic BMSCs in promoting wound healing. Administration of BMSCs labeled with iron oxides/1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate fluorescent dye revealed that systemically administered BMSCs engraft to the wound. The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound. In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds. ABSTRACT Bone marrow‐derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts, cartilage, bone, muscle, and brain cells. BMSCs also secrete a large number of growth factors and cytokines that are critical to the repair of injured tissues. Because of the extraordinary plasticity and the ability of syngeneic or allogeneic BMSCs to secrete tissue‐repair factors, we investigated the therapeutic efficacy of BMSCs for healing of fascial and cutaneous incisional wounds in Sprague–Dawley rats. Systemic administration of syngeneic BMSCs (2 × 10 6 ) once daily for 4 days or a single treatment with 5 × 10 6 BMSCs 24 hours after wounding significantly increased the wound bursting strength of fascial and cutaneous wounds on days 7 and 14 postwounding. Wound healing was also significantly improved following injection of BMSCs locally at the wound site. Furthermore, allogeneic BMSCs were as efficient as syngeneic BMSCs in promoting wound healing. Administration of BMSCs labeled with iron oxides/1,1′‐dioctadecyl‐3,3,3′,3′‐tetramethylindocarbocyanine perchlorate fluorescent dye revealed that systemically administered BMSCs engraft to the wound. The increase in the tensile strength of wounds treated with BMSCs was associated with increased production of collagen in the wound. In addition, BMSC treatment caused more rapid histologic maturation of wounds compared with untreated wounds. These data suggest that cell therapy with BMSCs has the potential to augment healing of surgical and cutaneous wounds. |
| Author | McFarlin, Kellie Gautam, Subhash C. Gao, Xiaohua Liu, Yong Bo Arbab, Ali S. Bansal, Mona Dulchavsky, Scott A. Dulchavsky, Deborah S. Li, Yi Kwon, David Chopp, Michael |
| Author_xml | – sequence: 1 givenname: Kellie surname: McFarlin fullname: McFarlin, Kellie organization: Department of Surgery – sequence: 2 givenname: Xiaohua surname: Gao fullname: Gao, Xiaohua organization: Department of Surgery – sequence: 3 givenname: Yong Bo surname: Liu fullname: Liu, Yong Bo organization: Department of Surgery – sequence: 4 givenname: Deborah S. surname: Dulchavsky fullname: Dulchavsky, Deborah S. organization: Department of Surgery – sequence: 5 givenname: David surname: Kwon fullname: Kwon, David organization: Department of Surgery – sequence: 6 givenname: Ali S. surname: Arbab fullname: Arbab, Ali S. organization: Department of Diagnostic Radiology – sequence: 7 givenname: Mona surname: Bansal fullname: Bansal, Mona organization: Department of Pathology, and – sequence: 8 givenname: Yi surname: Li fullname: Li, Yi organization: Department of Neurology, Henry Ford Health System, Detroit, Michigan – sequence: 9 givenname: Michael surname: Chopp fullname: Chopp, Michael organization: Department of Neurology, Henry Ford Health System, Detroit, Michigan – sequence: 10 givenname: Scott A. surname: Dulchavsky fullname: Dulchavsky, Scott A. organization: Department of Surgery – sequence: 11 givenname: Subhash C. surname: Gautam fullname: Gautam, Subhash C. organization: Department of Surgery |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/16939576$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1126/science.279.5356.1528 10.1016/S1474-4422(02)00040-6 10.1016/S1073-4449(97)70027-X 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7 10.1038/6529 10.1001/archderm.139.4.510 10.1002/hep.20469 10.1016/0140-6736(92)90143-Q 10.1046/j.1524-475x.2001.00347.x 10.1016/S0094-1298(20)32471-8 10.1097/00129334-200407000-00013 10.1634/stemcells.22-3-377 10.1006/jsre.1998.5326 10.1016/0014-5793(96)00240-2 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C 10.1056/NEJM199909023411006 10.2337/diacare.26.6.1856 10.1182/blood.V81.10.2547.2547 10.1016/S1357-2725(96)00134-3 10.1002/jcp.10260 10.1046/j.1440-1789.2002.00450.x 10.1073/pnas.181177898 10.1046/j.1523-1747.1998.00381.x 10.1111/j.1365-2133.2005.06402.x 10.1038/35070587 10.1042/BC20040099 10.1667/RR3189 10.12968/jowc.2005.14.3.26746 10.1016/j.mehy.2004.11.036 10.1182/blood.V89.5.1560 10.1016/S0741-5214(95)70142-7 10.1002/jor.1100090504 10.1182/blood-2004-02-0655 |
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| References | Loots MA, Lamme EN, Zeegelaar J, Mekkes JR, Bos JD, Middelkoop E. Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds. J Invest Dermatol 1998; 111: 850-7. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, Pickel J, McKay R, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Bone marrow cells regenerate infarcted myocardium. Nature 2001; 410: 701-5. Horowitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, Sussman M, Orchard P, Marx JC, Pyeritz RE, Brenner MK. Transplantability and therapeutic effects of bone marrow derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5: 309-13. Pittenger M, Vanguri P, Simonetti D, Young R. Adult mesenchymal stem cells: potential for muscle and tendon regeneration and use in gene therapy. J Musculoskelet Neuronal Interact 2002; 2: 309-20. Caplan AI. Mesenchymal stem cells. J Orthop Res 1991; 9: 641-50. Paul RG, Tarlton JF, Purslow PP, Sims TJ, Watkins P, Marshall F, Ferguson MJ, Bailey AJ. Biomechanical and biochemical study of a standardized wound healing model. Int J Biochem Cell Biol 1997; 29: 211-20. Ferguson MK. The effect of antineoplastic agents on wound healing. Surg Gynecol Obstet 1982; 154: 421-9. Sieggreen MY, Kline RA. Recognizing and managing venous leg ulcers. Adv Skin Wound Care 2004; 17: 302-11. Buckmire MA, Parquet G, Greenway S, Rolandelli RH. Temporal expression of TGF-β1, EGF, and PDGF-BB in a model of colonic wound healing. J Surg Res 1998; 80: 52-7. Steeper R. A critical review of the aetiology of diabetic neuropathic ulcers. J Wound Care 2005; 14: 101-3. Abboud SL. A bone marrow stromal cell line is a source and target for platelet-derived growth factor. Blood 1993; 81: 2547-53. Singer AJ, Clark RAF. Cutaneous wound healing. N Engl J Med 1999; 341: 738-46. Takai K, Hara J, Matsumoto K, Hosoi G, Osugi Y, Tawa A, Okada S, Nakamura T. Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis. Blood 1997; 89: 1560-5. Gomez NJ. Wound care management in the end-stage renal disease population. Adv Ren Replace Ther 1997; 4: 390-6. Badiavas EV, Falanga V. Treatment of chronic wounds with bone marrow-derived cells. Arch Dermatol 2003; 139: 510-6. Arbab AS, Yocum GT, Kalish H, Jordan EK, Anderson SA, Khakoo AY, Read EJ, Frank JA. Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI. Blood 2004; 104: 1217-122. Graves G, Cunningham P, Raaf JH. Effect of chemotherapy on healing of surgical wounds. Clin Bull 1980; 10: 144-9. Robson MC, Phillips LG, Falanga V, Odenheimer DJ, Parish LC, Jensen JL, Steed DL. Randomized trial of topically applied repifermin (recombinant human ulcer. keratinocyte growth factor-2) to accelerate wound healing in venous. Wound Rep Reg 2001; 9: 347-52. Johnson BL, Glickman MH, Bandyk DF, Esses GE. Failure of foot salvage in patients with end-stage renal disease after surgical revascularization. J Vasc Surg 1995; 22: 280-5. Steed DL. Modifying the wound healing response with exogenous growth factors. Clin Plast Surg 1998; 25: 397-405. Pierce GF, Tarpley JE, Allman RM, Goode PS, Serdar CM, Morris B, Mustoe TA, Vande Berg J. Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet-derived growth factor BB. Am J Pathol 1994; 145: 1399-410. Robson MC, Phillips LG, Thomason A, Robson LE, Pierce GF. Platelet-derived growth factor BB for the treatment of chronic pressure ulcers. Lancet 1992; 339: 23-5. Shi C, Cheng T, Su Y, Mai Y, Qu J, Lou S, Ran X, Xu H, Luo C. Transplantation of dermal multipotent cells promotes survival and wound healing in rats with combined radiation and wound injury. Radiat Res 2004; 162: 56-63. Heng BC, Liu H, Cao T. Transplanted human embryonic stem cells as biological "catalysts" for tissue repair and regeneration. Med Hypotheses 2005; 64: 1085-8. Orlic D, Kajstura J, Chimenti S, Limana F, Jakoniuk I, Quaini F, Nadal-Ginard B, Bodine DM, Leri A, Anversa P. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci USA 2001; 98: 10344-9. Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, Xu Y, Gautam SC, Chopp M. Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology 2002; 22: 275-9. Bello YM, Phillips TJ. Chronic leg ulcers: types and treatment. Hosp Pract (Off Ed) 2000; 35: 101-7. Anstead GM. Steroids, retinoids, and wound healing. Adv Wound Care 1998; 11: 277-85. Lee KD, Kuo TK, Whang-Peng J, Chung YF, Lin CT, Chou SH, Chen JR, Chen YP, Lee OK. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology 2004; 40: 1275-84. Woodbury D, Schwarz EJ, Prockop DJ, Black IB. Adult rat and human bone marrow stromal cells differentiate into neurons. J Neurosci Res 2000; 61: 364-70. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-4. Yoon YS, Lee N, Scadova H. Myocardial regeneration with bone-marrow-derived stem cells. Biol Cell 2005; 97: 253-63. Zimny S, Pfohl M. Healing times and prediction of wound healing in neuropathic diabetic foot ulcers: a prospective study. Exp Clin Endocrinol Diabetes 2005; 113: 90-3. Badiavas EV, Abedi M, Butmarc J, Falanga V, Quesenberry P. Participation of bone marrow derived cells in cutaneous wound healing. J Cell Physiol 2003; 196: 245-50. Majumdar MK, Thiede MA, Mosca JD, Moorman M, Gerson SL. Phenotypic and functional comparison of cultures of marrow derived mesenchymal stem cells (MSCs) and stromal cells. J Cellular Physiol 1998; 176: 57-66. Tsang MW, Wong WK, Hung CS, Lai KM, Tang W, Cheung EY, Kam G, Leung L, Chan CW, Chu CM, Lam EK. Human epidermal growth factor enhances healing of diabetic foot ulcers. Diabetes Care 2003; 26: 1856-61. Ferrari G, Angelis GC-D, Coletta M, Paolucci E, Stornatiuolo A, Cossu G, Mavilio F. Muscle regeneration by none marrow-derived myogenic progenitors. Science 1998; 279: 1528-30. Haynesworth SE, Baber MA, Caplan AI. Cytokine expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cellular Physiol 1996; 166: 585-92. Oswald J, Boxberger S, Jorgensen B, Feldmann S, Ehninger G, Bornhauser M, Werner C. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004; 22: 377-84. Bennett NT, Schultz GS. Growth factors and wound healing: biochemical properties of growth factors and their receptors. Am J Surg 1993; 165: 728-34. Chopp M, Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol 2002; 1: 92-100. Yamaguchi Y, Kubo T, Murakami T, Takahashi M, Hakamata Y, Kobayashi E, Yoshida S, Hosokawa K, Yoshikawa K, Itami S. Bone marrow cells differentiate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing. Br J Dermatol 2005; 152: 616-22. 2004; 22 2004; 40 2004; 104 2003; 139 2005; 152 2005; 113 1993; 81 2004; 162 1997; 276 1997; 89 2002; 1 2002; 2 1997; 29 1999; 341 2005; 64 1996; 166 1998; 279 1998; 80 1992 1998; 111 1998; 176 1997; 4 1999; 5 1991; 9 1993; 165 1998; 25 2003; 196 1994; 145 2001; 410 2004; 17 2000; 35 1995; 22 2001; 9 1980; 10 2002; 22 2000; 61 2003; 26 2005; 97 1982; 154 1992; 339 1998; 11 2005; 14 2001; 98 e_1_2_7_5_2 e_1_2_7_2_2 Gomez NJ. (e_1_2_7_4_2) 1997; 4 e_1_2_7_6_2 e_1_2_7_18_2 e_1_2_7_17_2 e_1_2_7_16_2 e_1_2_7_15_2 e_1_2_7_14_2 e_1_2_7_40_2 e_1_2_7_13_2 e_1_2_7_41_2 Bennett NT (e_1_2_7_42_2) 1993; 165 e_1_2_7_11_2 e_1_2_7_43_2 e_1_2_7_44_2 Pittenger M (e_1_2_7_19_2) 2002; 2 e_1_2_7_27_2 e_1_2_7_28_2 e_1_2_7_29_2 Haynesworth SE (e_1_2_7_26_2) 1996; 166 Zimny S (e_1_2_7_3_2) 2005; 113 Pierce GF (e_1_2_7_12_2) 1994; 145 Rudolph R (e_1_2_7_36_2) 1992 Graves G (e_1_2_7_9_2) 1980; 10 e_1_2_7_25_2 e_1_2_7_24_2 e_1_2_7_30_2 e_1_2_7_23_2 e_1_2_7_31_2 Bello YM (e_1_2_7_7_2) 2000; 35 Ferguson MK. (e_1_2_7_8_2) 1982; 154 e_1_2_7_22_2 e_1_2_7_32_2 Anstead GM. (e_1_2_7_10_2) 1998; 11 e_1_2_7_21_2 e_1_2_7_33_2 e_1_2_7_20_2 e_1_2_7_34_2 e_1_2_7_35_2 e_1_2_7_37_2 e_1_2_7_38_2 e_1_2_7_39_2 |
| References_xml | – volume: 1 start-page: 92 year: 2002 end-page: 100 article-title: Treatment of neural injury with marrow stromal cells publication-title: Lancet Neurol – volume: 410 start-page: 701 year: 2001 end-page: 5 article-title: Bone marrow cells regenerate infarcted myocardium publication-title: Nature – volume: 22 start-page: 377 year: 2004 end-page: 84 article-title: Mesenchymal stem cells can be differentiated into endothelial cells in vitro publication-title: Stem Cells – volume: 11 start-page: 277 year: 1998 end-page: 85 article-title: Steroids, retinoids, and wound healing publication-title: Adv Wound Care – volume: 162 start-page: 56 year: 2004 end-page: 63 article-title: Transplantation of dermal multipotent cells promotes survival and wound healing in rats with combined radiation and wound injury publication-title: Radiat Res – volume: 80 start-page: 52 year: 1998 end-page: 7 article-title: Temporal expression of TGF‐β1, EGF, and PDGF‐BB in a model of colonic wound healing publication-title: J Surg Res – volume: 22 start-page: 280 year: 1995 end-page: 5 article-title: Failure of foot salvage in patients with end‐stage renal disease after surgical revascularization publication-title: J Vasc Surg – volume: 145 start-page: 1399 year: 1994 end-page: 410 article-title: Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet‐derived growth factor BB publication-title: Am J Pathol – volume: 26 start-page: 1856 year: 2003 end-page: 61 article-title: Human epidermal growth factor enhances healing of diabetic foot ulcers publication-title: Diabetes Care – volume: 166 start-page: 585 year: 1996 end-page: 92 article-title: Cytokine expression by human marrow‐derived mesenchymal progenitor cells in vitro publication-title: effects of dexamethasone and IL-1 alpha – volume: 89 start-page: 1560 year: 1997 end-page: 5 article-title: Hepatocyte growth factor is constitutively produced by human bone marrow stromal cells and indirectly promotes hematopoiesis publication-title: Blood – volume: 111 start-page: 850 year: 1998 end-page: 7 article-title: Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds publication-title: J Invest Dermatol – volume: 176 start-page: 57 year: 1998 end-page: 66 article-title: Phenotypic and functional comparison of cultures of marrow derived mesenchymal stem cells (MSCs) and stromal cells publication-title: J Cellular Physiol – volume: 9 start-page: 641 year: 1991 end-page: 50 article-title: Mesenchymal stem cells publication-title: J Orthop Res – volume: 4 start-page: 390 year: 1997 end-page: 6 article-title: Wound care management in the end‐stage renal disease population publication-title: Adv Ren Replace Ther – volume: 152 start-page: 616 year: 2005 end-page: 22 article-title: Bone marrow cells differentiate into wound myofibroblasts and accelerate the healing of wounds with exposed bones when combined with an occlusive dressing publication-title: Br J Dermatol – volume: 341 start-page: 738 year: 1999 end-page: 46 article-title: Cutaneous wound healing publication-title: N Engl J Med – volume: 35 start-page: 101 year: 2000 end-page: 7 article-title: Chronic leg ulcers publication-title: types and treatment – volume: 81 start-page: 2547 year: 1993 end-page: 53 article-title: A bone marrow stromal cell line is a source and target for platelet‐derived growth factor publication-title: Blood – volume: 276 start-page: 71 year: 1997 end-page: 4 article-title: Marrow stromal cells as stem cells for nonhematopoietic tissues publication-title: Science – volume: 2 start-page: 309 year: 2002 end-page: 20 article-title: Adult mesenchymal stem cells publication-title: potential for muscle and tendon regeneration and use in gene therapy – volume: 5 start-page: 309 year: 1999 end-page: 13 article-title: Transplantability and therapeutic effects of bone marrow derived mesenchymal cells in children with osteogenesis imperfecta publication-title: Nat Med – volume: 10 start-page: 144 year: 1980 end-page: 9 article-title: Effect of chemotherapy on healing of surgical wounds publication-title: Clin Bull – volume: 139 start-page: 510 year: 2003 end-page: 6 article-title: Treatment of chronic wounds with bone marrow‐derived cells publication-title: Arch Dermatol – volume: 61 start-page: 364 year: 2000 end-page: 70 article-title: Adult rat and human bone marrow stromal cells differentiate into neurons publication-title: J Neurosci Res – start-page: 96 year: 1992 end-page: 114 – volume: 113 start-page: 90 year: 2005 end-page: 3 article-title: Healing times and prediction of wound healing in neuropathic diabetic foot ulcers publication-title: a prospective study – volume: 14 start-page: 101 year: 2005 end-page: 3 article-title: A critical review of the aetiology of diabetic neuropathic ulcers publication-title: J Wound Care – volume: 97 start-page: 253 year: 2005 end-page: 63 article-title: Myocardial regeneration with bone‐marrow‐derived stem cells publication-title: Biol Cell – volume: 154 start-page: 421 year: 1982 end-page: 9 article-title: The effect of antineoplastic agents on wound healing publication-title: Surg Gynecol Obstet – volume: 64 start-page: 1085 year: 2005 end-page: 8 article-title: Transplanted human embryonic stem cells as biological “catalysts” for tissue repair and regeneration publication-title: Med Hypotheses – volume: 29 start-page: 211 year: 1997 end-page: 20 article-title: Biomechanical and biochemical study of a standardized wound healing model publication-title: Int J Biochem Cell Biol – volume: 339 start-page: 23 year: 1992 end-page: 5 article-title: Platelet‐derived growth factor BB for the treatment of chronic pressure ulcers publication-title: Lancet – volume: 196 start-page: 245 year: 2003 end-page: 50 article-title: Participation of bone marrow derived cells in cutaneous wound healing publication-title: J Cell Physiol – volume: 104 start-page: 1217 year: 2004 end-page: 122 article-title: Efficient magnetic cell labeling with protamine sulfate complexed to ferumoxides for cellular MRI publication-title: Blood – volume: 165 start-page: 728 year: 1993 end-page: 34 article-title: Growth factors and wound healing publication-title: biochemical properties of growth factors and their receptors – volume: 17 start-page: 302 year: 2004 end-page: 11 article-title: Recognizing and managing venous leg ulcers publication-title: Adv Skin Wound Care – volume: 279 start-page: 1528 year: 1998 end-page: 30 article-title: Muscle regeneration by none marrow‐derived myogenic progenitors publication-title: Science – volume: 25 start-page: 397 year: 1998 end-page: 405 article-title: Modifying the wound healing response with exogenous growth factors publication-title: Clin Plast Surg – volume: 9 start-page: 347 year: 2001 end-page: 52 article-title: Randomized trial of topically applied repifermin (recombinant human ulcer. keratinocyte growth factor‐2) to accelerate wound healing in venous publication-title: Wound Rep Reg – volume: 40 start-page: 1275 year: 2004 end-page: 84 article-title: In vitro hepatic differentiation of human mesenchymal stem cells publication-title: Hepatology – volume: 98 start-page: 10344 year: 2001 end-page: 9 article-title: Mobilized bone marrow cells repair the infarcted heart, improving function and survival publication-title: Proc Natl Acad Sci USA – volume: 22 start-page: 275 year: 2002 end-page: 9 article-title: Ischemic rat brain extracts induce human marrow stromal cell growth factor production publication-title: Neuropathology – ident: e_1_2_7_22_2 doi: 10.1126/science.279.5356.1528 – ident: e_1_2_7_31_2 doi: 10.1016/S1474-4422(02)00040-6 – volume: 11 start-page: 277 year: 1998 ident: e_1_2_7_10_2 article-title: Steroids, retinoids, and wound healing publication-title: Adv Wound Care contributor: fullname: Anstead GM. – volume: 4 start-page: 390 year: 1997 ident: e_1_2_7_4_2 article-title: Wound care management in the end‐stage renal disease population publication-title: Adv Ren Replace Ther doi: 10.1016/S1073-4449(97)70027-X contributor: fullname: Gomez NJ. – ident: e_1_2_7_27_2 doi: 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7 – volume: 2 start-page: 309 year: 2002 ident: e_1_2_7_19_2 article-title: Adult mesenchymal stem cells publication-title: potential for muscle and tendon regeneration and use in gene therapy contributor: fullname: Pittenger M – ident: e_1_2_7_33_2 doi: 10.1038/6529 – ident: e_1_2_7_38_2 doi: 10.1001/archderm.139.4.510 – ident: e_1_2_7_23_2 doi: 10.1002/hep.20469 – ident: e_1_2_7_14_2 doi: 10.1016/0140-6736(92)90143-Q – ident: e_1_2_7_15_2 doi: 10.1046/j.1524-475x.2001.00347.x – ident: e_1_2_7_16_2 doi: 10.1016/S0094-1298(20)32471-8 – volume: 165 start-page: 728 year: 1993 ident: e_1_2_7_42_2 article-title: Growth factors and wound healing publication-title: biochemical properties of growth factors and their receptors contributor: fullname: Bennett NT – volume: 145 start-page: 1399 year: 1994 ident: e_1_2_7_12_2 article-title: Tissue repair processes in healing chronic pressure ulcers treated with recombinant platelet‐derived growth factor BB publication-title: Am J Pathol contributor: fullname: Pierce GF – ident: e_1_2_7_6_2 doi: 10.1097/00129334-200407000-00013 – ident: e_1_2_7_24_2 doi: 10.1634/stemcells.22-3-377 – ident: e_1_2_7_41_2 doi: 10.1006/jsre.1998.5326 – ident: e_1_2_7_44_2 doi: 10.1016/0014-5793(96)00240-2 – ident: e_1_2_7_25_2 doi: 10.1002/1097-4547(20000815)61:4<364::AID-JNR2>3.0.CO;2-C – ident: e_1_2_7_40_2 doi: 10.1056/NEJM199909023411006 – ident: e_1_2_7_13_2 doi: 10.2337/diacare.26.6.1856 – ident: e_1_2_7_28_2 doi: 10.1182/blood.V81.10.2547.2547 – ident: e_1_2_7_35_2 doi: 10.1016/S1357-2725(96)00134-3 – volume: 10 start-page: 144 year: 1980 ident: e_1_2_7_9_2 article-title: Effect of chemotherapy on healing of surgical wounds publication-title: Clin Bull contributor: fullname: Graves G – ident: e_1_2_7_37_2 doi: 10.1002/jcp.10260 – ident: e_1_2_7_30_2 doi: 10.1046/j.1440-1789.2002.00450.x – ident: e_1_2_7_32_2 doi: 10.1073/pnas.181177898 – start-page: 96 volume-title: Wound healing: biochemical and clinical aspects year: 1992 ident: e_1_2_7_36_2 contributor: fullname: Rudolph R – ident: e_1_2_7_11_2 doi: 10.1046/j.1523-1747.1998.00381.x – ident: e_1_2_7_39_2 doi: 10.1111/j.1365-2133.2005.06402.x – volume: 35 start-page: 101 year: 2000 ident: e_1_2_7_7_2 article-title: Chronic leg ulcers publication-title: types and treatment contributor: fullname: Bello YM – ident: e_1_2_7_20_2 doi: 10.1038/35070587 – ident: e_1_2_7_21_2 doi: 10.1042/BC20040099 – volume: 113 start-page: 90 year: 2005 ident: e_1_2_7_3_2 article-title: Healing times and prediction of wound healing in neuropathic diabetic foot ulcers publication-title: a prospective study contributor: fullname: Zimny S – volume: 154 start-page: 421 year: 1982 ident: e_1_2_7_8_2 article-title: The effect of antineoplastic agents on wound healing publication-title: Surg Gynecol Obstet contributor: fullname: Ferguson MK. – ident: e_1_2_7_17_2 doi: 10.1667/RR3189 – ident: e_1_2_7_2_2 doi: 10.12968/jowc.2005.14.3.26746 – ident: e_1_2_7_18_2 doi: 10.1016/j.mehy.2004.11.036 – ident: e_1_2_7_29_2 doi: 10.1182/blood.V89.5.1560 – ident: e_1_2_7_5_2 doi: 10.1016/S0741-5214(95)70142-7 – ident: e_1_2_7_43_2 doi: 10.1002/jor.1100090504 – volume: 166 start-page: 585 year: 1996 ident: e_1_2_7_26_2 article-title: Cytokine expression by human marrow‐derived mesenchymal progenitor cells in vitro publication-title: effects of dexamethasone and IL-1 alpha contributor: fullname: Haynesworth SE – ident: e_1_2_7_34_2 doi: 10.1182/blood-2004-02-0655 |
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Bone marrow‐derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including... Bone marrow-derived mesenchymal stromal cells (BMSCs) are multipotential stem cells capable of differentiation into numerous cell types, including fibroblasts,... |
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| SubjectTerms | Animals Bone Marrow Cells - physiology Collagen - metabolism Fascia - injuries Male Mesoderm - cytology Rats Rats, Sprague-Dawley Skin - injuries Stromal Cells - physiology Tensile Strength Wound Healing - physiology Wounds, Penetrating - metabolism Wounds, Penetrating - physiopathology |
| Title | Bone marrow-derived mesenchymal stromal cells accelerate wound healing in the rat |
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