Effect of omeprazole on oral and intravenous RS‐methadone pharmacokinetics and pharmacodynamics in the rat
The effect of omeprazole on oral and intravenous (iv) RS‐methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS‐methadone (3 mg/kg) was given (a) to a control group (COoral) (n = 65) and (b) to an omeprazole pretreated gro...
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| Published in | Journal of pharmaceutical sciences Vol. 91; no. 7; pp. 1627 - 1638 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Elsevier Inc
01.07.2002
Wiley Subscription Services, Inc., A Wiley Company Wiley American Pharmaceutical Association |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3549 1520-6017 |
| DOI | 10.1002/jps.10031 |
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| Abstract | The effect of omeprazole on oral and intravenous (iv) RS‐methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS‐methadone (3 mg/kg) was given (a) to a control group (COoral) (n = 65) and (b) to an omeprazole pretreated group (OPoral) (n = 77), and iv RS‐methadone (0.35 mg/kg) was administered (c) to a control group (COiv) (n = 86) and (d) to an omeprazole pretreated group (OPiv) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS‐methadone. Plasma concentrations of RS‐methadone (Cp) were determined by high‐performance liquid chromatography and analgesic response by tail flick for 0–180min (oral) and 0–120min (iv). RS‐Methadone rate of absorption (mean ± SE) was faster in OPoral (k01 = 0.31 ± 0.04min−1) than in COoral (k01 = 0.05 ± 0.007min−1), consequently plasma peak concentrations (Cmax) were greater (197.41 ± 33.70 ng/mL versus 83.54 ± 7.97 ng/mL) and the time to reach Cmax (tmax) was shorter (11.23 ± 1.32min versus 39.18 ± 1.74min). Mean area under the Cp‐time curve (AUC0–∞) and hence bioavailability of oral RS‐methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS‐methadone. The changes of the analgesic effect of RS‐methadone as a function of time were similar in all four groups. In the COoral group, Cp and analgesic effect were defined by the Emax model. The relationship between Cp and drug effect in the OPoral group showed a counterclockwise hysteresis (ke0 of 0.018 ± 0.006min−1). For the iv groups (COiv and OPiv), the Cp‐analgesic effect relationship was described by an Emax sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS‐methadone without modifying the analgesic response but affecting the Cp‐effect relationship. © 2002 Wiley‐Liss Inc. and the American Pharmaceutical Association J Pharm Sci 91:1627–1638, 2002 |
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| AbstractList | The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS-methadone (3 mg/kg) was given (a) to a control group (CO(oral)) (n = 65) and (b) to an omeprazole pretreated group (OP(oral)) (n = 77), and iv RS-methadone (0.35 mg/kg) was administered (c) to a control group (CO(iv)) (n = 86) and (d) to an omeprazole pretreated group (OP(iv)) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS-methadone. Plasma concentrations of RS-methadone (Cp) were determined by high-performance liquid chromatography and analgesic response by tail flick for 0-180 min (oral) and 0-120 min (iv). RS-Methadone rate of absorption (mean +/- SE) was faster in OP(oral) (k(01) = 0.31 +/- 0.04 min(-1)) than in CO(oral) (k(01) = 0.05 +/- 0.007 min(-1)), consequently plasma peak concentrations (C(max)) were greater (197.41 +/- 33.70 ng/mL versus 83.54 +/- 7.97 ng/mL) and the time to reach C(max) (t(max)) was shorter (11.23 +/- 1.32 min versus 39.18 +/- 1.74 min). Mean area under the Cp-time curve (AUC(0-infinity)) and hence bioavailability of oral RS-methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS-methadone. The changes of the analgesic effect of RS-methadone as a function of time were similar in all four groups. In the CO(oral) group, Cp and analgesic effect were defined by the E(max) model. The relationship between Cp and drug effect in the OP(oral) group showed a counterclockwise hysteresis (k(e0) of 0.018 +/- 0.006 min(-1)). For the iv groups (CO(iv) and OP(iv)), the Cp-analgesic effect relationship was described by an E(max) sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS-methadone without modifying the analgesic response but affecting the Cp-effect relationship. The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS-methadone (3 mg/kg) was given (a) to a control group (CO(oral)) (n = 65) and (b) to an omeprazole pretreated group (OP(oral)) (n = 77), and iv RS-methadone (0.35 mg/kg) was administered (c) to a control group (CO(iv)) (n = 86) and (d) to an omeprazole pretreated group (OP(iv)) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS-methadone. Plasma concentrations of RS-methadone (Cp) were determined by high-performance liquid chromatography and analgesic response by tail flick for 0-180 min (oral) and 0-120 min (iv). RS-Methadone rate of absorption (mean +/- SE) was faster in OP(oral) (k(01) = 0.31 +/- 0.04 min(-1)) than in CO(oral) (k(01) = 0.05 +/- 0.007 min(-1)), consequently plasma peak concentrations (C(max)) were greater (197.41 +/- 33.70 ng/mL versus 83.54 +/- 7.97 ng/mL) and the time to reach C(max) (t(max)) was shorter (11.23 +/- 1.32 min versus 39.18 +/- 1.74 min). Mean area under the Cp-time curve (AUC(0-infinity)) and hence bioavailability of oral RS-methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS-methadone. The changes of the analgesic effect of RS-methadone as a function of time were similar in all four groups. In the CO(oral) group, Cp and analgesic effect were defined by the E(max) model. The relationship between Cp and drug effect in the OP(oral) group showed a counterclockwise hysteresis (k(e0) of 0.018 +/- 0.006 min(-1)). For the iv groups (CO(iv) and OP(iv)), the Cp-analgesic effect relationship was described by an E(max) sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS-methadone without modifying the analgesic response but affecting the Cp-effect relationship.The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS-methadone (3 mg/kg) was given (a) to a control group (CO(oral)) (n = 65) and (b) to an omeprazole pretreated group (OP(oral)) (n = 77), and iv RS-methadone (0.35 mg/kg) was administered (c) to a control group (CO(iv)) (n = 86) and (d) to an omeprazole pretreated group (OP(iv)) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS-methadone. Plasma concentrations of RS-methadone (Cp) were determined by high-performance liquid chromatography and analgesic response by tail flick for 0-180 min (oral) and 0-120 min (iv). RS-Methadone rate of absorption (mean +/- SE) was faster in OP(oral) (k(01) = 0.31 +/- 0.04 min(-1)) than in CO(oral) (k(01) = 0.05 +/- 0.007 min(-1)), consequently plasma peak concentrations (C(max)) were greater (197.41 +/- 33.70 ng/mL versus 83.54 +/- 7.97 ng/mL) and the time to reach C(max) (t(max)) was shorter (11.23 +/- 1.32 min versus 39.18 +/- 1.74 min). Mean area under the Cp-time curve (AUC(0-infinity)) and hence bioavailability of oral RS-methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS-methadone. The changes of the analgesic effect of RS-methadone as a function of time were similar in all four groups. In the CO(oral) group, Cp and analgesic effect were defined by the E(max) model. The relationship between Cp and drug effect in the OP(oral) group showed a counterclockwise hysteresis (k(e0) of 0.018 +/- 0.006 min(-1)). For the iv groups (CO(iv) and OP(iv)), the Cp-analgesic effect relationship was described by an E(max) sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS-methadone without modifying the analgesic response but affecting the Cp-effect relationship. The effect of omeprazole on oral and intravenous (iv) RS‐methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS‐methadone (3 mg/kg) was given (a) to a control group (COoral) (n = 65) and (b) to an omeprazole pretreated group (OPoral) (n = 77), and iv RS‐methadone (0.35 mg/kg) was administered (c) to a control group (COiv) (n = 86) and (d) to an omeprazole pretreated group (OPiv) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS‐methadone. Plasma concentrations of RS‐methadone (Cp) were determined by high‐performance liquid chromatography and analgesic response by tail flick for 0–180min (oral) and 0–120min (iv). RS‐Methadone rate of absorption (mean ± SE) was faster in OPoral (k01 = 0.31 ± 0.04min−1) than in COoral (k01 = 0.05 ± 0.007min−1), consequently plasma peak concentrations (Cmax) were greater (197.41 ± 33.70 ng/mL versus 83.54 ± 7.97 ng/mL) and the time to reach Cmax (tmax) was shorter (11.23 ± 1.32min versus 39.18 ± 1.74min). Mean area under the Cp‐time curve (AUC0–∞) and hence bioavailability of oral RS‐methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS‐methadone. The changes of the analgesic effect of RS‐methadone as a function of time were similar in all four groups. In the COoral group, Cp and analgesic effect were defined by the Emax model. The relationship between Cp and drug effect in the OPoral group showed a counterclockwise hysteresis (ke0 of 0.018 ± 0.006min−1). For the iv groups (COiv and OPiv), the Cp‐analgesic effect relationship was described by an Emax sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS‐methadone without modifying the analgesic response but affecting the Cp‐effect relationship. © 2002 Wiley‐Liss Inc. and the American Pharmaceutical Association J Pharm Sci 91:1627–1638, 2002 The effect of omeprazole on oral and intravenous (iv) RS‐methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were divided in four groups: oral RS‐methadone (3 mg/kg) was given (a) to a control group (COoral) (n = 65) and (b) to an omeprazole pretreated group (OPoral) (n = 77), and iv RS‐methadone (0.35 mg/kg) was administered (c) to a control group (COiv) (n = 86) and (d) to an omeprazole pretreated group (OPiv) (n = 86). Omeprazole (2 mg/kg) was given iv 2 h before RS‐methadone. Plasma concentrations of RS‐methadone (Cp) were determined by high‐performance liquid chromatography and analgesic response by tail flick for 0–180 min (oral) and 0–120 min (iv). RS‐Methadone rate of absorption (mean ± SE) was faster in OPoral (k01 = 0.31 ± 0.04 min−1) than in COoral (k01 = 0.05 ± 0.007 min−1), consequently plasma peak concentrations (Cmax) were greater (197.41 ± 33.70 ng/mL versus 83.54 ± 7.97 ng/mL) and the time to reach Cmax (tmax) was shorter (11.23 ± 1.32 min versus 39.18 ± 1.74 min). Mean area under the Cp‐time curve (AUC0–∞) and hence bioavailability of oral RS‐methadone were increased by omeprazole without significant changes in the elimination. Omeprazole did not affect the pharmacokinetics of iv RS‐methadone. The changes of the analgesic effect of RS‐methadone as a function of time were similar in all four groups. In the COoral group, Cp and analgesic effect were defined by the Emax model. The relationship between Cp and drug effect in the OPoral group showed a counterclockwise hysteresis (ke0 of 0.018 ± 0.006 min−1). For the iv groups (COiv and OPiv), the Cp‐analgesic effect relationship was described by an Emax sigmoid model and omeprazole did not affect the pharmacodynamic parameters. It is concluded that omeprazole causes an increase in the bioavailability of oral RS‐methadone without modifying the analgesic response but affecting the Cp‐effect relationship. © 2002 Wiley‐Liss Inc. and the American Pharmaceutical Association J Pharm Sci 91:1627–1638, 2002 |
| Author | Carlos, M. Angeles Lukas, John C. Calvo, Rosario Souich, Patrick Du Carlos, Raimundo Suarez, Elena |
| Author_xml | – sequence: 1 givenname: M. Angeles surname: Carlos fullname: Carlos, M. Angeles organization: Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa, 48940 Spain – sequence: 2 givenname: Patrick Du surname: Souich fullname: Souich, Patrick Du organization: Department of Pharmacology, Faculty of Medicine, University of Montreal, Montreal, Quebec, Canada – sequence: 3 givenname: Raimundo surname: Carlos fullname: Carlos, Raimundo organization: Department of Pharmacology, School of Medicine, University of Granada, Granada, Spain – sequence: 4 givenname: Elena surname: Suarez fullname: Suarez, Elena organization: Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa, 48940 Spain – sequence: 5 givenname: John C. surname: Lukas fullname: Lukas, John C. organization: Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa, 48940 Spain – sequence: 6 givenname: Rosario surname: Calvo fullname: Calvo, Rosario email: charo@u.washington.edu organization: Department of Pharmacology, School of Medicine, University of the Basque Country, Leioa, 48940 Spain |
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| Keywords | pharmacokinetics omeprazole methadone analgesia Stomach Pharmacokinetic pharmacodynamic relationship Drug combination Intravenous administration Rat Digestive system Rodentia Oral administration Opiates Antiulcer agent Methadone Blood Proton pump inhibitor Blood plasma Omeprazole Vertebrata Mammalia Analgesic Benzimidazole derivatives Animal pH Drug interaction Pharmacokinetics |
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| Publisher | Elsevier Inc Wiley Subscription Services, Inc., A Wiley Company Wiley American Pharmaceutical Association |
| Publisher_xml | – name: Elsevier Inc – name: Wiley Subscription Services, Inc., A Wiley Company – name: American Pharmaceutical Association – name: Wiley |
| References | Sommers, van Wyk, Snyman, Moncrieff (bb0110) 1992; 43 Tucker, Lennard (bb0165) 1990; 45 Unge, Svedberg, Nordgren, Blom, Andersson, Lagerstrom, Idstrom (bb0200) 1992; 34 Julkunen (bb0205) 1976; 54 Ripamonti, Zecca, Bruera (bb0030) 1997; 70 Dyer, Foster, White, Somogyi, Menelaou, Bochner (bb0035) 1999; 65 Sutfin, Balmér, Boström, Eriksson, Höglund, Paulsen (bb0195) 1989; 11 Bouer, Barthe, Philibert, Tournaire, Woodley, Houin (bb0220) 1999; 13 Eap, Cuendet, Baumann (bb0160) 1990; 47 Julkunen (bb0210) 1976; 28 Levy, Boddy (bb0170) 1991; 8 Hayball, Wrobel, Tamblyn, Mation (bb0190) 1994; 37 Flockhart (bb0130) 1995; 29 Garrido, Valle, Calvo, Troconiz (bb0080) 1999; 288 Misra, Mule, Bloch, Vadlamani (bb0135) 1973; 185 Kristensen, Blemmer, Angelo, Christrup, Drenck, Rasmussen, Sjogren (bb0055) 1996; 18 Andersson (bb0125) 1991; 21 Fainsinger, Schoeller, Bruera (bb0025) 1993; 52 Wolff, Sanderson, Hay, Raistrick (bb0075) 1991; 37 De Castro, Aguirre, Rodriguez‐Sasiaín, Gómez, Garrido, Calvo (bb0070) 1996; 17 Kristensen, Christensen, Christrup (bb0145) 1995; 56 Vogelgesang, Echizen, Schmidt, Eichelbaum (bb0150) 1984; 18 Unadkat, Bartha, Sheiner (bb0090) 1986; 40 Hutt, Tan (bb0175) 1996; 52 Giraud, Sanduja, Felder, Illich, Dial, Lichtenberger (bb0095) 1997; 11 D'Amour, Smith (bb0085) 1941; 72 Eap, Finkbeiner, Gastpar, Sicherbaum, Powell, Baumann (bb0180) 1996; 50 Oosterhuis, Jonkman, Andersson, Zuiderwijk, Jedema (bb0105) 1991; 32 Farrell, Ward, Mattick, Hall, Stimson, des Jarlais, Gossop, Strang (bb0020) 1994; 309 Ling, Umans, Inturrisi (bb0140) 1981; 217 Inturrisi, Colburn, Kaiko, Houden, Foley (bb0040) 1987; 41 Nilsson, Anggard, Holmstrand, Gunne (bb0060) 1982; 22 Meresaar, Nilsson, Holmstrand, Anggard (bb0010) 1981; 20 Hansten (bb0120) 1991; 5 Gibaldi (bb0050) 1991 Teng, Dogolo, Willavize, Friedman, Vincent (bb0100) 1997; 39 Kristensen, Blemmer, Angelo, Christrup, Drenck, Rasmussen, Sjogren (bb0155) 1996; 18 Zhang, Dunbar, Ostrowska, Zeisloft, Yang, Kaminsky (bb0215) 1999; 27 Marier, Pichette, du Souich (bb0225) 1998; 26 Rostami‐Hodjegan, Wolff, Hay, Raistrick, Calvert, Tucker (bb0045) 1999; 48 Soons, van den Berg, Danhof, van Brummelen, Jansen, Lamers, Breimer (bb0115) 1992; 42 Wolff, Rostami‐Hodjegan, Shires, Hay, Feely, Calvert, Raistrick, Tucker (bb0015) 1997; 44 Gibaldi (bb0185) 1993; 5 Foster, Somogyi, Bochner (bb0065) 1999; 47 Ling GS, Umans JG, Inturrisi CE. 1981. Methadone: Radio-immunoassay and pharmacokinetics in the rat. J Pharmacol Exp Ther 217: 147-151. Soons PA, van den Berg G, Danhof M, van Brummelen P, Jansen JB, Lamers CB, Breimer DD. 1992. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects. Eur J Clin Pharmacol 42: 319-324. Julkunen RJ. 1976. The absorption of warfarin from the rat stomach in situ. Med Biol 54: 260-263. Hutt AJ, Tan SC. 1996. Drug chirality and its clinical significance. Drugs 52(Suppl 5):1-12. Dyer KR, Foster DJ, White JM, Somogyi AA, Menelaou A, Bochner F. 1999. Steady-state pharmacokinetics and pharmacodynamics in methadone maintenance patients: Comparison of those who do and do not experience withdrawal and concentration-effect relationships. Clin Pharmacol Ther 65: 685-694. Meresaar U, Nilsson MI, Holmstrand J, Anggard E. 1981. Single dose pharmacokinetics and bioavailability of methadone in man studied with a stable isotope method. Eur J Clin Pharmacol 20: 473-478. Ripamonti C, Zecca E, Bruera E. 1997. An update on the clinical use of methadone for cancer pain. Pain 70: 109-115. Unge P, Svedberg LE, Nordgren A, Blom H, Andersson T, Lagerstrom PO, Idstrom JP. 1992. A study of the interaction of omeprazole and warfarin in anticoagulated patients. Br J Clin Pharmacol 34: 509-512. Flockhart DA. 1995. Drug interactions and the cytochrome P450 system: The role of cytochrome P450 2C19. Clin Pharmacokinet 29(Suppl 1):45-52. Fainsinger R, Schoeller T, Bruera E. 1993. Methadone in the management of cancer pain: A review. Pain 52: 137-147. Julkunen RJ. 1976. The absorption of warfarin from the rat small intestine in situ. J Pharm Pharmacol 28: 493-497. Foster DJ, Somogyi AA, Bochner F. 1999. Methadone N-demethylation in human liver microsomes: Lack of stereoselectivity and involvement of CYP3A4. Br J Clin Pharmacol 47: 403-412. Eap CB, Finkbeiner T, Gastpar M, Sicherbaum M, Powell K, Baumann P. 1996. Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: Interindividual variability of the R/S ratios and evidence of adaptive changes in methadone pharmacokinetics. Eur J Clin Pharmacol 50: 385-389. Kristensen K, Christensen CB, Christrup LL. 1995. The mu1, mu2, delta, kappa opioid receptor binding profiles of methadone stereoisomers and morphine. Life Sci 56: 45-50. Wolff K, Rostami-Hodjegan A, Shires S, Hay AWM, Feely M, Calvert R, Raistrick D, Tucker GT. 1997. The pharmacokinetics of methadone in healthy subjects and opiate users. Br J Clin Pharmacol 44: 325-334. Eap CB, Cuendet C, Baumann P. 1990. Binding of d-methadone, l-methadone and dl-methadone to protein in plasma of healthy volunteers: Role of the variants of α1-acid glycoprotein. Clin Pharmacol Ther 47: 338-346. Marier JF, Pichette V, du Souich P. 1998. Stereoselective disposition of propranolol in rabbits: Role of presystemic organs and dose. Drug Metab Dispos 26: 164-169. Levy RH, Boddy AV. 1991. Stereoselectivity in pharmacokinetics: A general theory. Pharm Res 8: 551-556. Sommers DK, van Wyk M, Snyman JR, Moncrieff J. 1992. The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation. Eur J Clin Pharmacol 43: 141-143. Bouer R, Barthe L, Philibert C, Tournaire C, Woodley J, Houin G. 1999. The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: In vitro studies using the rat everted intestinal sac. Fundam Clin Pharmacol 13: 494-500. Giraud MN, Sanduja SK, Felder TB, Illich PA, Dial EJ, Lichtenberger LM. 1997. Effect of omeprazole on the bioavailability of un-modified and phospholipid-complexed aspirin in rats. Aliment Pharmacol Ther 11: 899-906. Hayball PJ, Wrobel J, Tamblyn JG, Mation RL. 1994. The pharmacokinetics of ketorolac enantiomers following intramuscular administration of the racemate. Br J Clin Pharmacol 37: 75-78. Garrido MJ, Valle M, Calvo R, Troconiz IF. 1999. Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats. J Pharmacol Exp Ther 288: 179-187. Misra AL, Mule SJ, Bloch R, Vadlamani NL. 1973. Physiological disposition and metabolism of levo-methadone-l-3H in nontolerant and tolerant rats. J Pharmacol Exp Ther 185: 287-299. Oosterhuis B, Jonkman JH, Andersson T, Zuiderwijk PB, Jedema JN. 1991. Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose. Br J Clin Pharmacol 32: 569-572. Kristensen K, Blemmer T, Angelo HR, Christrup LL, Drenck NE, Rasmussen SM, Sjogren P. 1996. Stereoselective pharmacokinetics of methadone in chronic pain patients. Ther Drug Monit 18: 221-227. Farrell M, Ward J, Mattick R, Hall W, Stimson GV, des Jarlais D, Gossop M, Strang J. 1994. Methadone maintenance treatment in opiate dependence: A review. Br Med J 309: 997-1001. Nilsson MI, Anggard E, Holmstrand H, Gunne M. 1982. Pharmacokinetics of methadone during maintenance treatment: Adaptive changes during the induction phase. Eur J Clin Pharmacol 22: 343-349. Gibaldi M. 1993. Stereoselective and isozyme-selective drug interactions. Chirality 5: 407-413. Sutfin T, Balmér K, Boström H, Eriksson S, Höglund P, Paulsen O. 1989. Stereoselective interaction of omeprazole with warfarin in healthy men. Ther Drug Monit 11: 176-184. Inturrisi CE, Colburn WA, Kaiko RF, Houden RW, Foley KM. 1987. Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther 41: 392-401. Wolff K, Sanderson M, Hay AWM, Raistrick D. 1991. Methadone concentrations in plasma and their relationship to drug dosage. Clin Chem 37: 205-209. D'Amour FE, Smith DL. 1941. A method for determining loss of pain sensation. J Pharmacol Exp Ther 72: 74-79. Rostami-Hodjegan D, Wolff W, Hay AWM, Raistrick D, Calvert R, Tucker GT. 1999. Population pharmacokinetics of methadone in opiate users: Characterization of time-dependent changes. Br J Clin Pharmacol 48: 43-52. Tucker GT, Lennard MS. 1990. Enantiomer specific pharmacokinetics. Pharmacol Ther 45: 309-329. Kristensen K, Blemmer T, Angelo HR, Christrup LL, Drenck NE, Rasmussen SN, Sjogren P. 1996. Stereoselective pharmacokinetics of methadone in chronic pain patients. Ther Drug Monit 18: 221-227. Hansten PD. 1991. Drug interactions with antisecretory agents. Aliment Pharmacol Ther 5 ( Suppl 1):121-128. Vogelgesang B, Echizen H, Schmidt E, Eichelbaum M. 1984. Stereoselective first-pass metabolism of highly cleared drugs: Studies of the bioavailability of L- and D-verapamil examined with a stable isotope technique. Br J Clin Pharmacol 18: 733-740. Andersson T. 1991. Omeprazole drug interaction studies. Clin Pharmacokinet 21: 195-212. De Castro J, Aguirre C, Rodriguez-Sasiaín JM, Gómez E, Garrido MJ, Calvo R. 1996. The effect of changes in gastric pH induced by omeprazole on the absorption and respiratory depression of methadone. Biopharm Drug Dispos 17: 551-563. Unadkat JD, Bartha F, Sheiner LB. 1986. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther 40: 86-93. Zhang QY, Dunbar D, Ostrowska A, Zeisloft S, Yang J, Kaminsky LS. 1999. Characterization of human small intestinal cytochromes P-450. Drug Metab Dispos 27: 804-809. Teng R, Dogolo LC, Willavize SA, Friedman HL, Vincent J. 1997. Effect of Maalox and omeprazole on the bioavailability of trovafloxacin. 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| References_xml | – volume: 21 start-page: 195 year: 1991 end-page: 212 ident: bb0125 article-title: Omeprazole drug interaction studies publication-title: Clin Pharmacokinet – volume: 42 start-page: 319 year: 1992 end-page: 324 ident: bb0115 article-title: Influence of single‐ and multiple‐dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects publication-title: Eur J Clin Pharmacol – start-page: 40 year: 1991 end-page: 60 ident: bb0050 article-title: Gastrointestinal absorption: Physicochemical considerations publication-title: Biopharmaceutics and clinical pharmacokinetics – volume: 47 start-page: 403 year: 1999 end-page: 412 ident: bb0065 article-title: Methadone N‐demethylation in human liver microsomes: Lack of stereoselectivity and involvement of CYP3A4 publication-title: Br J Clin Pharmacol – volume: 47 start-page: 338 year: 1990 end-page: 346 ident: bb0160 article-title: Binding of d‐methadone, l‐methadone and dl‐methadone to protein in 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methadone in chronic pain patients publication-title: Ther Drug Monit – volume: 32 start-page: 569 year: 1991 end-page: 572 ident: bb0105 article-title: Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose publication-title: Br J Clin Pharmacol – volume: 43 start-page: 141 year: 1992 end-page: 143 ident: bb0110 article-title: The effects of omeprazole‐induced hypochlorhydria on absorption of theophylline from a sustained‐release formulation publication-title: Eur J Clin Pharmacol – volume: 50 start-page: 385 year: 1996 end-page: 389 ident: bb0180 article-title: Replacement of ( publication-title: Eur J Clin Pharmacol – volume: 56 start-page: 45 year: 1995 end-page: 50 ident: bb0145 article-title: The mu publication-title: Life Sci – reference: Tucker GT, Lennard MS. 1990. Enantiomer specific pharmacokinetics. Pharmacol Ther 45: 309-329. – reference: Julkunen RJ. 1976. The absorption of warfarin from the rat small intestine in situ. J Pharm Pharmacol 28: 493-497. – reference: D'Amour FE, Smith DL. 1941. A method for determining loss of pain sensation. J Pharmacol Exp Ther 72: 74-79. – reference: Eap CB, Cuendet C, Baumann P. 1990. Binding of d-methadone, l-methadone and dl-methadone to protein in plasma of healthy volunteers: Role of the variants of α1-acid glycoprotein. Clin Pharmacol Ther 47: 338-346. – reference: Levy RH, Boddy AV. 1991. Stereoselectivity in pharmacokinetics: A general theory. Pharm Res 8: 551-556. – reference: Gibaldi M. 1993. Stereoselective and isozyme-selective drug interactions. Chirality 5: 407-413. – reference: Marier JF, Pichette V, du Souich P. 1998. Stereoselective disposition of propranolol in rabbits: Role of presystemic organs and dose. Drug Metab Dispos 26: 164-169. – reference: Farrell M, Ward J, Mattick R, Hall W, Stimson GV, des Jarlais D, Gossop M, Strang J. 1994. Methadone maintenance treatment in opiate dependence: A review. Br Med J 309: 997-1001. – reference: Inturrisi CE, Colburn WA, Kaiko RF, Houden RW, Foley KM. 1987. Pharmacokinetics and pharmacodynamics of methadone in patients with chronic pain. Clin Pharmacol Ther 41: 392-401. – reference: Unge P, Svedberg LE, Nordgren A, Blom H, Andersson T, Lagerstrom PO, Idstrom JP. 1992. A study of the interaction of omeprazole and warfarin in anticoagulated patients. Br J Clin Pharmacol 34: 509-512. – reference: Garrido MJ, Valle M, Calvo R, Troconiz IF. 1999. Altered plasma and brain disposition and pharmacodynamics of methadone in abstinent rats. J Pharmacol Exp Ther 288: 179-187. – reference: Andersson T. 1991. Omeprazole drug interaction studies. Clin Pharmacokinet 21: 195-212. – reference: Wolff K, Rostami-Hodjegan A, Shires S, Hay AWM, Feely M, Calvert R, Raistrick D, Tucker GT. 1997. The pharmacokinetics of methadone in healthy subjects and opiate users. Br J Clin Pharmacol 44: 325-334. – reference: Soons PA, van den Berg G, Danhof M, van Brummelen P, Jansen JB, Lamers CB, Breimer DD. 1992. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects. Eur J Clin Pharmacol 42: 319-324. – reference: Eap CB, Finkbeiner T, Gastpar M, Sicherbaum M, Powell K, Baumann P. 1996. Replacement of (R)-methadone by a double dose of (R,S)-methadone in addicts: Interindividual variability of the R/S ratios and evidence of adaptive changes in methadone pharmacokinetics. Eur J Clin Pharmacol 50: 385-389. – reference: Rostami-Hodjegan D, Wolff W, Hay AWM, Raistrick D, Calvert R, Tucker GT. 1999. Population pharmacokinetics of methadone in opiate users: Characterization of time-dependent changes. Br J Clin Pharmacol 48: 43-52. – reference: Sommers DK, van Wyk M, Snyman JR, Moncrieff J. 1992. The effects of omeprazole-induced hypochlorhydria on absorption of theophylline from a sustained-release formulation. Eur J Clin Pharmacol 43: 141-143. – reference: Unadkat JD, Bartha F, Sheiner LB. 1986. Simultaneous modeling of pharmacokinetics and pharmacodynamics with nonparametric kinetic and dynamic models. Clin Pharmacol Ther 40: 86-93. – reference: Oosterhuis B, Jonkman JH, Andersson T, Zuiderwijk PB, Jedema JN. 1991. Minor effect of multiple dose omeprazole on the pharmacokinetics of digoxin after a single oral dose. Br J Clin Pharmacol 32: 569-572. – reference: Wolff K, Sanderson M, Hay AWM, Raistrick D. 1991. Methadone concentrations in plasma and their relationship to drug dosage. Clin Chem 37: 205-209. – reference: Hayball PJ, Wrobel J, Tamblyn JG, Mation RL. 1994. 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| Snippet | The effect of omeprazole on oral and intravenous (iv) RS‐methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were... The effect of omeprazole on oral and intravenous (iv) RS-methadone pharmacokinetics and pharmacodynamics was studied in awake, freely moving rats, which were... |
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| SubjectTerms | Administration, Oral analgesia Analgesics Animals Biological and medical sciences Digestive system Drug Synergism Female Injections, Intravenous Medical sciences methadone Methadone - administration & dosage Methadone - blood Methadone - pharmacokinetics Neuropharmacology omeprazole Omeprazole - pharmacokinetics Omeprazole - pharmacology Pain Measurement - drug effects pharmacokinetics Pharmacology. Drug treatments Rats Rats, Sprague-Dawley |
| Title | Effect of omeprazole on oral and intravenous RS‐methadone pharmacokinetics and pharmacodynamics in the rat |
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